WEDNESDAY 13.03.2024
09:30 Mentoring session
11:00 Registration
12:00 Welcome and introduction
Keynote lecture I
12:10 Hiro Nakauchi (Stanford Medicine)
The Stem Cell Niche and Beyond: xenocreated organs for rejection free transplantation
13:10 Equity, Diversity, and Inclusion (EDI) at the Vienna Biocenter
13:15 Lunch break
Session 1 - early embryogenesis
14:30 Jan Żylicz (University of Copenhagen)
Epi-metabolic coupling coordinates early development
15:00 Agnese Loda (European Molecular Biology Laboratory)
Escape from X inactivation is directly modulated by Xist RNA levels
15:15 Claudia Gerri (Max Planck Institute of Molecular Cell Biology and Genetics)
The fetal-maternal interface across species
15:45 Coffee break
16:15 Berna Sozen (Yale School of Medicine)
Stem Cell Modeling of Multicellular Organization and Patterning in Human Post-Implantation Embryonic Development
16:45 Kristina Stapornwongkul (EMBL Barcelona)
Metabolic control of germ layer proportions through regulation of Nodal and Wnt signalling
17:00 Break
Session 2 – part I - lineage specification
17:30 Vicki Metzis (Imperial College London)
Motif substitution toggles Cdx2 silencer function during posterior body formation
18:00 Alexandre Mayran (École polytechnique fédérale de Lausanne)
Cadherins modulate the self-organizing potential of gastruloids
18:15 Xavier Trepat (Institute for Bioengineering of Catalonia)
Linking force, form and function in intestinal organoids and tumoroids
18:45 Marek van Oostrom (Hubrecht Institute)
Linking molecular oscillators: coupling the segmentation clock and the cell cycle in mouse embryonic explants
19:00 Symposium dinner
THURSDAY 14.03.2024
Session 2 – part II - lineage specification
09:00 Eyal Karzbrun (Weizmann Institute of Science)
Tubular morphogenesis in a dish
09:30 Julia Batki (Max Planck Institute for Molecular Genetics)
Cell fate regulation of extraembryonic cells in the developing gut
09:45 Stefan Jahnel (Institute of Molecular Biotechnology)
Role of hyaluronic acid in morphogenesis and physiology of human cardiac organoids
10:00 Coffee break
Session 3 – nervous systems development
10:30 Fides Zenk (École polytechnique fédérale de Lausanne)
Single-cell epigenomic reconstruction of developmental trajectories in human neural organoid systems
11:00 Sakurako Nagumo Wong (Institute of Molecular Biotechnology)
Interneurons drive network pathology in tuberous sclerosis
11:15 Johan Jakobsson (Lund University Moore)
Transposable elements and the evolution of the human brain
11:45 Break
12:15 Marisa Karow (Friedrich-Alexander-Universität Erlangen-Nürnberg)
Dynamic X-chromosomal reactivation enhances female brain resilience in the context of neurodevelopment disorders
12:45 Tomohisa Toda (German Center for Neurodegenerative Diseases/Friedrich-Alexander Universität Erlangen-Nürnberg)
Life-long persistence of nuclear RNA in the mammalian brain
13:00 Group picture
13:15 Lunch break
Session 4 – part I – brain disease and regeneration
14:30 In-Hyun Park (Yale Stem Cell Center)
Generation of human diencephalic organoids to investigate neurodevelopmental disorders
15:00 Francesca Merighi (University of Pisa)
Stem cell and nanomedicine based regenerative approaches for treating spinal cord injuries
15:15 Poster session I
18:00 Networking event: SY-Stem pub quiz
19:00 Speaker dinner [only by invitation]
Friday 15.03.2024
Session 4 – part II – brain disease and regeneration
09:00 Mina Gouti (Max Delbrück Center for Molecular Medicine) [EMBO Young Investigator Lecture]
Building advanced neuromuscular models to study human development and disease.
09:30 Daniel Del Toro (University of Barcelona)
Expansion of the neocortex and protection from neurodegeneration by in vivo transient reprogramming
10:00 Coffee break
Session 5 – part I – novel technologies
10:30 Minhee Park (Korea Advanced Institute of Science and Technology)
To build and visualize chromatin: Understanding epigenetic memory
11:00 Nike Walther (University of California, Berkeley)
Automated live-cell single-molecule imaging reveals the molecular dynamics of overexpressed Sox9 associated with a morphological change and proliferative cell state transition in intestinal organoids
11:15 Joanna Jachowicz (Institute of Molecular Biotechnology)
Single-cell measurement of higher-order 3D genome organization with scSPRITE
11:45 Kirstin Meyer (University of California San Francisco)
Unraveling a dynamic YAP communication code for stem cell fate and proliferation
12:15 Lunch break
13:00 Poster session II
Session 5 – part II – novel technologies
15:00 Peter Zeller (Hubrecht Institute)
Understanding chromatin regulation during in vitro embryonic development using single-cell multi-omics
15:30 Anastasia Polikarpova (IMP - Research Institute of Molecular Pathology)
Exploring the Cellular and Molecular Landscape of Critical Bone Fractures in Axolotls
15:45 break
Keynote lecture II
16:00 Magdalena Götz (Helmholtz Munich)
Novel mechanisms of neurogenesis and neural repair
17:00 Closing remarks
17:15 Light bites & farewell