Wednesday, 15th May 2019
| 9.00 - 11.00 | Registration & poster setup |
| 11.00 | Welcome & introduction |
Session 1 | Genome Defense (Chair: Julius Brennecke)
| 11.15 - 11.45 | Steve Jacobsen, University of California, Los Angeles DNA methylation in Arabidopsis |
| 11.45 - 12.15 | Scott Kennedy, Harvard Medical School Biomolecular Condensates in Epigenetic Inheritance and Genome Defense |
| 12.15 - 12.45 | Peter Sarkies, MRC London Institute of Medical Sciences Epimutations driven by small RNAs occur rapidly but have limited duration in a metazoan organism. |
| 12.45 | Group picture |
| 12.50 - 14.00 | Lunch & poster set up |
Session 2| Argonautes & Other RBPs (Chair: Stefan Ameres)
| 14.00 - 14.30 |
Julie Claycomb, University of Toronto
Argonomics: A Systematic Analysis of Argonaute Proteins in C. elegans
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| 14.30 - 14.45 | Lukas Paul, LEXOGEN sponsored talk The short and long of RNA-Seq |
| 14.45 - 15.15 | Markus Landthaler, Max Delbrück Center for Molecular Medicine Posttranscriptional regulation in space and time |
| 15.15 - 15.45 | Coffee Break |
PhD Workshop - Part 1
| 15.45 - 16.05 | Elena Kingston, Whitehead Institute, MIT (David Bartel Lab) Global analyses of the dynamics of mammalian microRNA metabolism |
| 16.05 - 16.25 | Marzia Munafo, Cancer Research UK - Cambridge Institute (Greg Hannon Lab) Daedalus and Gasz recruit Armitage to mitochondria, bringing piRNA precursors to the biogenesis machinery |
| 16.25 - 16.45 | Ranjith Papareddy, Gregor Mendel Institute of Molecular Plant Biology (Michael Nodine Lab) Small RNA regulation of DNA methylation dynamics during Arabidopsis embryogenesis |
| 16.45 - 17.15 | Coffee Break |
Session 3| RNA Metabolism I (Chair: Stefan Ameres)
| 17.15 - 17.45 | Nicolas Battich, Hubrecht Institute (Alexander van Oudenaarden Lab) Sequencing metabolically labeled transcripts in single cells reveals recurrent mRNA turnover strategies |
| 17.45 - 18.15 | Zissimos Mourelatos, University of Pennsylvania Ribothrypsis: Mechanisms and Implications |
Dinner at the IMP Cafeteria and Poster session at IMBA Atrium
Thursday, 16th May 2019
Session 4 | RNA Metabolism II (Chair: Clemens Plaschka)
| 9.00 - 9.30 | Brian Gregory, University of Pennsylvania Arabidopsis DXO1 functions in both NAD+-decapping to inhibit small RNA processing from messenger RNAs as well as in co-translational RNA decay |
| 9.30 - 09.45 | Gabriele Christoffel, QIAGEN sponsored talk What could you be missing out from your samples? A sample to insight walk-through a miRNA workflow |
| 09.45 - 10.15 | Alena Shkumatava, Institut Curie MicroRNA Degradation by a Conserved Target RNA Regulates Animal Behavior |
| 10.15 - 10.45 | Coffee Break |
| 10.45 - 11.15 | Alex Tuck, Friedrich Miescher Institute (Marc Buehler Lab) RNA degradation: a dangerous message |
| 11.15 - 11.45 | Katharina Markmann, University of Tuebingen A micro RNA acts as a systemic mediator of symbiotic susceptibility |
| 11.45 - 12.00 | Short break |
PhD Workshop - Part 2
| 12.00 - 12.20 | Samson Jolly, University of Massachusetts Medical School (Phillip D. Zamore Lab) An Unexpected Role for a Prokaryotic Argonaute Protein in DNA Replication |
| 12.20 - 12.40 | Rob Maple, University of Warwick (Jose Gutierrez-Marcos Lab) Meiosis-associated argonaute (MAGO) proteins are necessary for meiosis in maize |
| 12.40 - 13.00 | Arie Fridrich, The Hebrew University of Jerusalem (Yehu Moran Lab) Ancient subfunctionalization of Argonautes and the crucial developmental roles of their microRNAs in Cnidaria |
| 13.00 - 14.30 | Lunch & poster session |
Session 5 | Inheritance (Chair: Luisa Cochella)
| 14.30 - 15.00 | Laura Landweber, Columbia University Small RNAs in development in the ciliate Oxytricha |
| 15.00 - 15.30 | René Ketting, Institute of Molecular Biology Paternal inheritance of an Argonaute protein in C. elegans via novel germ granules |
| 15.30 - 16.00 | Coffee Break |
PhD Workshop - Part 3
| 16.00 - 16.20 | Ida Marie Sjøgaard, University of Copenhagen (Peter Brodersen Lab) Molecular characterization of interactors of the N-coil of ARGONAUTE1 and factors mediating its degradation |
| 16.20 - 16.40 | Itai Antoine Toker, Tel Aviv University (Oded Rechavi Lab) Biogenesis of Neuronal Small RNAs Controls Behavior Transgenerationally |
| 16.40 - 17.00 | Piergiuseppe Quarato, Institut Pasteur (Germano Cecere Lab) Endogenous siRNAs facilitate the clearance of maternal mRNAs during maternal-to-zygotic transition |
Tour and dinner for academic speakers/Bar for PhD Workshop speakers
Friday, 17th May 2019
Session 6 | Mechanisms of Silencing (Chair: Andrea Pauli)
| 9.00 - 9.30 | Eric Miska, University of Cambridge Inheritance beyond DNA sequence: news from worms and fishes |
| 9.30 - 10.00 | Andrea McCue, Ohio State University (R. Keith Slotkin Lab) Initiation of Silencing via expression-dependent de novo RNA-directed DNA Methylation |
| 10.00 - 10.30 | Emanuel Devers, ETH Zürich (Olivier Voinnet Lab) Movement and consumption of unloaded siRNA duplexes underlie potentially unlimited patterns of mobile RNAi |
| 10.30 - 11.00 | Coffee Break |
Session 7 | Noncoding RNAs (Chair: Javier Martinez)
| 11.00 - 11.30 | Rastislav Horos, EMBL Heidelberg (Matthias Hentze Lab) The small non-coding vault RNA1-1 regulates p62-dependent autophagy and aggregate clearance |
| 11.30 - 12.00 | Claudia Kutter, Karolinska Institutet Transcriptional architecture and regulation of mammalian noncoding RNAs |
| 12.00 - 12.30 | Karla Meza, Harvard Medical School (Judy Lieberman Lab) SPARCLE, a p53-induced RNA that controls apoptosis after genomic stress |
| 12.30 - 15.00 | Lunch & Poster session |
Session 8 | Differentiation & Development (Chair: Michael Nodine)
| 15.00 - 15.30 | Amy Pasquinelli, University of California San Diego Elucidating the Dark Side of the MicroRNA |
15.30 - 16.00 | Luisa Cochella, Research Institute of Molecular Pathology Roles of miRNAs in animal development |
16.00 - 16.30 | Helge Grosshans, Friedrich Miescher Institute A protease for small RNA function in the germline |
| 16.30 | Awards and closing of the meeting |
| 17.00 | Light bites and socializing |