Publications

Search Publications

Year	Title	Journal	Authors
2020	A human tissue screen identifies a regulator of ER secretion as a brain size determinant.	Science	Esk, C., Lindenhofer, D., Haendeler, S., Wester, RA., Pflug, F., Schroeder, B., Bagley, JA., Elling, U., Zuber, J., von Haeseler, A., Knoblich, JA.
2020	Multilayered VBC score predicts sgRNAs that efficiently generate loss-of-function alleles.	Nat Methods	Michlits, G., Jude, J., Hinterndorfer, M., de Almeida, M., Vainorius, G., Hubmann, M., Neumann, T., Schleiffer, A., Burkard, TR., Fellner, M., Gijsbertsen, M., Traunbauer, A., Zuber, J., Elling, U.
2019	Using Functional Genetics in Haploid Cells for Drug Target Identification.	Methods Mol Biol	Volz, JC., Schuller, N., Elling, U.
2019	Canonical PRC1 controls sequence-independent propagation of Polycomb-mediated gene silencing.	Nat Commun	Moussa, HF., Bsteh, D., Yelagandula, R., Pribitzer, C., Stecher, K., Bartalska, K., Michetti, L., Wang, J., Zepeda-Martinez, JA., Elling, U., Stuckey, JI., James, LI., Frye, SV., Bell, O.
2019	Derivation and maintenance of mouse haploid embryonic stem cells.	Nat Protoc	Elling, U., Woods, M., Forment, JV., Fu, B., Yang, F., Ng, BL., Vicente, JR., Adams, DJ., Doe, B., Jackson, SP., Penninger, JM., Balmus, G.
2019	CRISPR-Switch regulates sgRNA activity by Cre recombination for sequential editing of two loci.	Nat Commun	Chylinski, K., Hubmann, M., Hanna, RE., Yanchus, C., Michlits, G., Uijttewaal, ECH., Doench, J., Schramek, D., Elling, U.
2019	The novel lncRNA lnc-NR2F1 is pro-neurogenic and mutated in human neurodevelopmental disorders.	Elife	Ang, CE., Ma, Q., Wapinski, OL., Fan, S., Flynn, RA., Lee, QY., Coe, B., Onoguchi, M., Olmos, VH., Do, BT., Dukes-Rimsky, L., Xu, J., Tanabe, K., Wang, L., Elling, U., Penninger, JM., Zhao, Y., Qu, K., Eichler, EE., Srivastava, A., Wernig, M., Chang, HY.
2018	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.	Hum Genet	Stephen, J., Nampoothiri, S., Banerjee, A., Tolman, NJ., Penninger, JM., Elling, U., Agu, CA., Burke, JD., Devadathan, K., Kannan, R., Huang, Y., Steinbach, PJ., Martinis, SA., Gahl, WA., Malicdan, MCV.
2018	Unbiased compound-protein interface mapping and prediction of chemoresistance loci through forward genetics in haploid stem cells.	Oncotarget	Horn, M., Kroef, V., Allmeroth, K., Schuller, N., Miethe, S., Peifer, M., Penninger, JM., Elling, U., Denzel, MS.
2018	Neutralizing Gatad2a-Chd4-Mbd3/NuRD Complex Facilitates Deterministic Induction of Naive Pluripotency.	Cell Stem Cell	Mor, N., Rais, Y., Sheban, D., Peles, S., Aguilera-Castrejon, A., Zviran, A., Elinger, D., Viukov, S., Geula, S., Krupalnik, V., Zerbib, M., Chomsky, E., Lasman, L., Shani, T., Bayerl, J., Gafni, O., Hanna, S., Buenrostro, JD., Hagai, T., Masika, H., Vainorius, G., Bergman, Y., Greenleaf, WJ., Esteban, MA., Elling, U., Levin, Y., Massarwa, R., Merbl, Y., Novershtern, N., Hanna, JH.
2017	Comparative glycoproteomics of stem cells identifies new players in ricin toxicity.	Nature	Stadlmann, J., Taubenschmid, J., Wenzel, D., Gattinger, A., Dürnberger, G., Dusberger, F., Elling, U., Mach, L., Mechtler, K., Penninger, JM.
2017	A reversible haploid mouse embryonic stem cell biobank resource for functional genomics.	Nature	Elling, U., Wimmer, RA., Leibbrandt, A., Burkard, T., Michlits, G., Leopoldi, A., Micheler, T., Abdeen, D., Zhuk, S., Aspalter, IM., Handl, C., Liebergesell, J., Hubmann, M., Husa, AM., Kinzer, M., Schuller, N., Wetzel, E., van de Loo, N., Martinez, JAZ., Estoppey, D., Riedl, R., Yang, F., Fu, B., Dechat, T., Ivics, Z., Agu, CA., Bell, O., Blaas, D., Gerhardt, H., Hoepfner, D., Stark, A., Penninger, JM.
2017	CRISPR-UMI: single-cell lineage tracing of pooled CRISPR-Cas9 screens.	Nat Methods	Michlits, G., Hubmann, M., Wu, SH., Vainorius, G., Budusan, E., Zhuk, S., Burkard, TR., Novatchkova, M., Aichinger, M., Lu, Y., Reece-Hoyes, J., Nitsch, R., Schramek, D., Hoepfner, D., Elling, U.
2017	A vital sugar code for ricin toxicity.	Cell Res	Taubenschmid, J., Stadlmann, J., Jost, M., Klokk, TI., Rillahan, CD., Leibbrandt, A., Mechtler, K., Paulson, JC., Jude, J., Zuber, J., Sandvig, K., Elling, U., Marquardt, T., Thiel, C., Koerner, C., Penninger, JM.
2017	DUSP9 Modulates DNA Hypomethylation in Female Mouse Pluripotent Stem Cells.	Cell Stem Cell	Choi, J., Clement, K., Huebner, AJ., Webster, J., Rose, CM., Brumbaugh, J., Walsh, RM., Lee, S., Savol, A., Etchegaray, JP., Gu, H., Boyle, P., Elling, U., Mostoslavsky, R., Sadreyev, R., Park, PJ., Gygi, SP., Meissner, A., Hochedlinger, K.
2016	Mutations in the murine homologue of TUBB5 cause microcephaly by perturbing cell cycle progression and inducing p53-associated apoptosis.	Development	Breuss, M., Fritz, T., Gstrein, T., Chan, K., Ushakova, L., Yu, N., Vonberg, FW., Werner, B., Elling, U., Keays, DA.
2016	The mevalonate pathway regulates primitive streak formation via protein farnesylation.	Sci Rep	Okamoto-Uchida, Y., Yu, R., Miyamura, N., Arima, N., Ishigami-Yuasa, M., Kagechika, H., Yoshida, S., Hosoya, T., Nawa, M., Kasama, T., Asaoka, Y., Alois, RW., Elling, U., Penninger, JM., Nishina, S., Azuma, N., Nishina, H.
2015	The histone chaperone CAF-1 safeguards somatic cell identity.	Nature	Cheloufi, S., Elling, U., Hopfgartner, B., Jung, YL., Murn, J., Ninova, M., Hubmann, M., Badeaux, AI., Euong Ang, C., Tenen, D., Wesche, DJ., Abazova, N., Hogue, M., Tasdemir, N., Brumbaugh, J., Rathert, P., Jude, J., Ferrari, F., Blanco, A., Fellner, M., Wenzel, D., Zinner, M., Vidal, SE., Bell, O., Stadtfeld, M., Chang, HY., Almouzni, G., Lowe, SW., Rinn, J., Wernig, M., Aravin, A., Shi, Y., Park, PJ., Penninger, JM., Zuber, J., Hochedlinger, K.
2014	Genome wide functional genetics in haploid cells.	FEBS Lett	Elling, U., Penninger, JM.
2014	JAGN1 deficiency causes aberrant myeloid cell homeostasis and congenital neutropenia.	Nat Genet	Boztug, K., Järvinen, PM., Salzer, E., Racek, T., Mönch, S., Garncarz, W., Gertz, EM., Schäffer, AA., Antonopoulos, A., Haslam, SM., Schieck, L., Puchałka, J., Diestelhorst, J., Appaswamy, G., Lescoeur, B., Giambruno, R., Bigenzahn, JW., Elling, U., Pfeifer, D., Conde, CD., Albert, MH., Welte, K., Brandes, G., Sherkat, R., van der Werff Ten Bosch, J., Rezaei, N., Etzioni, A., Bellanné-Chantelot, C., Superti-Furga, G., Penninger, JM., Bennett, KL., von Blume, J., Dell, A., Donadieu, J., Klein, C.