RNAI SCREEN DATABASES
Neuroblasts Screen online database
The Neuroblasts Screen is a project carried out in Jürgen Knoblich's lab.You can access the data produced by the genome wide screen.
- Single Gene Search: a simple search form to find particular genes by any gene identifier (CG Number, Flybase ID, etc).
- Genes List Search: search for a list of selected gene identifiers simultaneously.
- Phenotype Search: search for lines matching a set of specified phenotypic scores.
Bristle Screen online database
The Bristle Screen is a project carried out in Jürgen Knoblich's lab. The website is the point of access to the scientific data that has been obtained as a result of the research process. Listed below you can find a brief description of the different sections of this site.
- Project Information: all the basic information about the project. A scientific overview of it's background and the research process.
- Database Summary: some raw numbers and global statistics of the results obtained in the the screen.
- Basic Search: a simple search form to find particular genes by name.
- Advanced Search: an advanced search form to find screened lines that match a set of specified criteria.
- CG List Search: gives the possibility to search for a selection of CG numbers at the same time.
- Download DB: offers a single file with all the contents of the database in XLS format
Below is a collection of time-lapse videos illustrating the process of asymmetric cell division in Drosophila sensory organ precursor (SOP) cells. SOP cells are one of the best characterized model systems for asymmetric cell division as they generate the four different cell types constituting Drosophila external sensory organs in a stereotyped lineage. See the following reviews for further information:
Knoblich, J.A. (2008). Mechanisms of asymmetric stem cell division. Cell 132, 583-597.
Neumuller, R.A., and Knoblich, J. A. (2009). Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer. Genes Dev 23, 2675-2699.
Knoblich, J.A. (2010). Asymmetric cell division: recent developments and their implications for tumour biology. Nat Rev Mol Cell Biol 11, 849-860.
Homem, C.C.F., and Knoblich, J.A. (2012). Drosophila neuroblasts: a model for stem cell biology. Development 139, 4297-4310.
In all movies, a fusion between Histone-2A and RFP labels DNA.