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Publications

Year Title Journal Authors
2020 Fibroblasts as a source of self-antigens for central immune tolerance. Nat Immunol Nitta, T., Tsutsumi, M., Nitta, S., Muro, R., Suzuki, EC., Nakano, K., Tomofuji, Y., Sawa, S., Okamura, T., Penninger, JM., Takayanagi, H.
2020 Reduced Prenatal Pulmonary Lymphatic Function Is Observed in Clp1 K/K Embryos With Impaired Motor Functions Including Fetal Breathing Movements in Preparation of the Developing Lung for Inflation at Birth. Front Bioeng Biotechnol Szoták-Ajtay, K., Szõke, D., Kovács, G., Andréka, J., Brenner, GB., Giricz, Z., Penninger, J., Kahn, ML., Jakus, Z.
2020 Targeting the RANKL/RANK/OPG Axis for Cancer Therapy. Front Oncol Ming, J., Cronin, SJF., Penninger, JM.
2020 CLP1 acts as the main RNA kinase in mice. Biochem Biophys Res Commun Fujinami, H., Shiraishi, H., Hada, K., Inoue, M., Morisaki, I., Higa, R., Shin, T., Kobayashi, T., Hanada, R., Penninger, JM., Mimata, H., Hanada, T.
2020 B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction. Nat Commun Minato, T., Nirasawa, S., Sato, T., Yamaguchi, T., Hoshizaki, M., Inagaki, T., Nakahara, K., Yoshihashi, T., Ozawa, R., Yokota, S., Natsui, M., Koyota, S., Yoshiya, T., Yoshizawa-Kumagaye, K., Motoyama, S., Gotoh, T., Nakaoka, Y., Penninger, JM., Watanabe, H., Imai, Y., Takahashi, S., Kuba, K.
2020 Tyrosine pre-transfer RNA fragments are linked to p53-dependent neuronal cell death via PKM2. Biochem Biophys Res Commun Inoue, M., Hada, K., Shiraishi, H., Yatsuka, H., Fujinami, H., Morisaki, I., Nishida, Y., Matsubara, E., Ishitani, T., Hanada, R., Matsumoto, M., Penninger, JM., Ihara, K., Hanada, T.
2020 Overexpression of apoptosis inducing factor aggravates hypoxic-ischemic brain injury in neonatal mice. Cell Death Dis Li, T., Li, K., Zhang, S., Wang, Y., Xu, Y., Cronin, SJF., Sun, Y., Zhang, Y., Xie, C., Rodriguez, J., Zhou, K., Hagberg, H., Mallard, C., Wang, X., Penninger, JM., Kroemer, G., Blomgren, K., Zhu, C.
2020 Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target. Intensive Care Med Zhang, H., Penninger, JM., Li, Y., Zhong, N., Slutsky, AS.
2020 Sigma-1 receptors control neuropathic pain and macrophage infiltration into the dorsal root ganglion after peripheral nerve injury. FASEB J Bravo-Caparrós, I., Ruiz-Cantero, MC., Perazzoli, G., Cronin, SJF., Vela, JM., Hamed, MF., Penninger, JM., Baeyens, JM., Cobos, EJ., Nieto, FR.
2020 RANKL and OPG and their influence on breast volume changes during pregnancy in healthy women. Sci Rep Wunderle, M., Ruebner, M., Häberle, L., Schwenke, E., Hack, CC., Bayer, CM., Koch, MC., Schwitulla, J., Schulz-Wendtland, R., Kozieradzki, I., Lux, MP., Beckmann, MW., Jud, SM., Penninger, JM., Schneider, MO., Fasching, PA.
2020 Salmonella-based platform for efficient delivery of functional binding proteins to the cytosol. Commun Biol Chabloz, A., Schaefer, JV., Kozieradzki, I., Cronin, SJF., Strebinger, D., Macaluso, F., Wald, J., Rabbitts, TH., Plückthun, A., Marlovits, TC., Penninger, JM.
2020 HACE1 prevents lung carcinogenesis via inhibition of RAC-family GTPases. Cancer Res Kogler, M., Tortola, L., Negri, GL., Leopoldi, A., El-Naggar, AM., Mereiter, S., Gomez Diaz, C., Nitsch, R., Tortora, D., Kavirayani, AM., Gapp, BV., Rao, S., Uribesalgo, I., Hoffmann, D., Cikes, D., Novatchkova, M., Williams, DA., Trent, JM., Ikeda, F., Daugaard, M., Hagelkruys, A., Sorensen, PH., Penninger, JM.
2020 Identification of ALK in Thinness. Cell Orthofer, M., Valsesia, A., Mägi, R., Wang, QP., Kaczanowska, J., Kozieradzki, I., Leopoldi, A., Cikes, D., Zopf, LM., Tretiakov, EO., Demetz, E., Hilbe, R., Boehm, A., Ticevic, M., Nõukas, M., Jais, A., Spirk, K., Clark, T., Amann, S., Lepamets, M., Neumayr, C., Arnold, C., Dou, Z., Kuhn, V., Novatchkova, M., Cronin, SJF., Tietge, UJF., Müller, S., Pospisilik, JA., Nagy, V., Hui, CC., Lazovic, J., Esterbauer, H., Hagelkruys, A., Tancevski, I., Kiefer, FW., Harkany, T., Haubensak, W., Neely, GG., Metspalu, A., Hager, J., Gheldof, N., Penninger, JM.
2020 Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2. Cell Monteil, V., Kwon, H., Prado, P., Hagelkrüys, A., Wimmer, RA., Stahl, M., Leopoldi, A., Garreta, E., Hurtado Del Pozo, C., Prosper, F., Romero, JP., Wirnsberger, G., Zhang, H., Slutsky, AS., Conder, R., Montserrat, N., Mirazimi, A., Penninger, JM.
2020 Dysregulation in Akt/mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells. Emerg Microbes Infect Appelberg, S., Gupta, S., Svensson Akusjärvi, S., Ambikan, AT., Mikaeloff, F., Saccon, E., Végvári, Á., Benfeitas, R., Sperk, M., Ståhlberg, M., Krishnan, S., Singh, K., Penninger, JM., Mirazimi, A., Neogi, U.
2020 Sclerostin expression in trabecular bone is downregulated by osteoclasts. Sci Rep Koide, M., Yamashita, T., Murakami, K., Uehara, S., Nakamura, K., Nakamura, M., Matsushita, M., Ara, T., Yasuda, H., Penninger, JM., Takahashi, N., Udagawa, N., Kobayashi, Y.
2020 A synthetic peptide library for benchmarking crosslinking-mass spectrometry search engines for proteins and protein complexes. Nat Commun Beveridge, R., Stadlmann, J., Penninger, JM., Mechtler, K.
2019 Targeting APLN/APLNR Improves Antiangiogenic Efficiency and Blunts Proinvasive Side Effects of VEGFA/VEGFR2 Blockade in Glioblastoma. Cancer Res Mastrella, G., Hou, M., Li, M., Stoecklein, VM., Zdouc, N., Volmar, MNM., Miletic, H., Reinhard, S., Herold-Mende, CC., Kleber, S., Eisenhut, K., Gargiulo, G., Synowitz, M., Vescovi, AL., Harter, PN., Penninger, JM., Wagner, E., Mittelbronn, M., Bjerkvig, R., Hambardzumyan, D., Schüller, U., Tonn, JC., Radke, J., Glass, R., Kälin, RE.
2019 Generation of blood vessel organoids from human pluripotent stem cells. Nat Protoc Wimmer, RA., Leopoldi, A., Aichinger, M., Kerjaschki, D., Penninger, JM.
2019 Targeting the MKK7-JNK (Mitogen-Activated Protein Kinase Kinase 7-c-Jun N-Terminal Kinase) Pathway with Covalent Inhibitors. J Med Chem Wolle, P., Hardick, J., Cronin, SJF., Engel, J., Baumann, M., Lategahn, J., Penninger, JM., Rauh, D.