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Publications

Year Title Journal Authors
2019 Targeting the MKK7-JNK (Mitogen-Activated Protein Kinase Kinase 7-c Jun N-Terminal Kinase) Pathway with Covalent Inhibitors. J Med Chem Wolle, P., Hardick, J., Cronin, SJF., Engel, J., Baumann, M., Lategahn, J., Penninger, J., Rauh, D.
2019 Human blood vessel organoids as a model of diabetic vasculopathy. Nature Wimmer, RA., Leopoldi, A., Aichinger, M., Wick, N., Hantusch, B., Novatchkova, M., Taubenschmid, J., Hämmerle, M., Esk, C., Bagley, JA., Lindenhofer, D., Chen, G., Boehm, M., Agu, CA., Yang, F., Fu, B., Zuber, J., Knoblich, JA., Kerjaschki, D., Penninger, JM.
2019 JNK signalling mediates aspects of maternal immune activation: importance of maternal genotype in relation to schizophrenia risk. J Neuroinflammation Openshaw, RL., Kwon, J., McColl, A., Penninger, JM., Cavanagh, J., Pratt, JA., Morris, BJ.
2019 RANK deletion in neuropeptide Y neurones attenuates oestrogen deficiency-related bone loss. J Neuroendocrinol Lee, NJ., Clarke, IM., Zengin, A., Enriquez, RF., Nagy, V., Penninger, JM., Baldock, PA., Herzog, H.
2019 The novel lncRNA <i>lnc-NR2F1</i> is pro-neurogenic and mutated in human neurodevelopmental disorders. Elife Ang, CE., Ma, Q., Wapinski, OL., Fan, S., Flynn, RA., Lee, QY., Coe, B., Onoguchi, M., Olmos, VH., Do, BT., Dukes-Rimsky, L., Xu, J., Tanabe, K., Wang, L., Elling, U., Penninger, JM., Zhao, Y., Qu, K., Eichler, EE., Srivastava, A., Wernig, M., Chang, HY.
2018 A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer. PLoS Genet Zoranovic, T., Manent, J., Willoughby, L., Matos de Simoes, R., La Marca, JE., Golenkina, S., Cuiping, X., Gruber, S., Angjeli, B., Kanitz, EE., Cronin, SJF., Neely, GG., Wernitznig, A., Humbert, PO., Simpson, KJ., Mitsiades, CS., Richardson, HE., Penninger, JM.
2018 Afatinib restrains K-RAS-driven lung tumorigenesis. Sci Transl Med Moll, HP., Pranz, K., Musteanu, M., Grabner, B., Hruschka, N., Mohrherr, J., Aigner, P., Stiedl, P., Brcic, L., Laszlo, V., Schramek, D., Moriggl, R., Eferl, R., Moldvay, J., Dezso, K., Lopez-Casas, PP., Stoiber, D., Hidalgo, M., Penninger, J., Sibilia, M., Gy?rffy, B., Barbacid, M., Dome, B., Popper, H., Casanova, E.
2018 The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function. Sci Signal Yamaguchi, T., Suzuki, T., Sato, T., Takahashi, A., Watanabe, H., Kadowaki, A., Natsui, M., Inagaki, H., Arakawa, S., Nakaoka, S., Koizumi, Y., Seki, S., Adachi, S., Fukao, A., Fujiwara, T., Natsume, T., Kimura, A., Komatsu, M., Shimizu, S., Ito, H., Suzuki, Y., Penninger, JM., Yamamoto, T., Imai, Y., Kuba, K.
2018 Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity. Cell Rep Timper, K., Paeger, L., Sánchez-Lasheras, C., Varela, L., Jais, A., Nolte, H., Vogt, MC., Hausen, AC., Heilinger, C., Evers, N., Pospisilik, JA., Penninger, JM., Taylor, EB., Horvath, TL., Kloppenburg, P., Brüning, JC.
2018 Cardiac regeneration in a newborn: what does this mean for future cardiac repair research? Expert Rev Cardiovasc Ther Haubner, BJ., Schuetz, T., Penninger, JM.
2018 Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ Galluzzi, L., Vitale, I., Aaronson, SA., Abrams, JM., Adam, D., Agostinis, P., Alnemri, ES., Altucci, L., Amelio, I., Andrews, DW., Annicchiarico-Petruzzelli, M., Antonov, AV., Arama, E., Baehrecke, EH., Barlev, NA., Bazan, NG., Bernassola, F., Bertrand, MJM., Bianchi, K., Blagosklonny, MV., Blomgren, K., Borner, C., Boya, P., Brenner, C., Campanella, M., Candi, E., Carmona-Gutierrez, D., Cecconi, F., Chan, FK., Chandel, NS., Cheng, EH., Chipuk, JE., Cidlowski, JA., Ciechanover, A., Cohen, GM., Conrad, M., Cubillos-Ruiz, JR., Czabotar, PE., D'Angiolella, V., Dawson, TM., Dawson, VL., De Laurenzi, V., De Maria, R., Debatin, KM., DeBerardinis, RJ., Deshmukh, M., Di Daniele, N., Di Virgilio, F., Dixit, VM., Dixon, SJ., Duckett, CS., Dynlacht, BD., El-Deiry, WS., Elrod, JW., Fimia, GM., Fulda, S., García-Sáez, AJ., Garg, AD., Garrido, C., Gavathiotis, E., Golstein, P., Gottlieb, E., Green, DR., Greene, LA., Gronemeyer, H., Gross, A., Hajnoczky, G., Hardwick, JM., Harris, IS., Hengartner, MO., Hetz, C., Ichijo, H., Jäättelä, M., Joseph, B., Jost, PJ., Juin, PP., Kaiser, WJ., Karin, M., Kaufmann, T., Kepp, O., Kimchi, A., Kitsis, RN., Klionsky, DJ., Knight, RA., Kumar, S., Lee, SW., Lemasters, JJ., Levine, B., Linkermann, A., Lipton, SA., Lockshin, RA., López-Otín, C., Lowe, SW., Luedde, T., Lugli, E., MacFarlane, M., Madeo, F., Malewicz, M., Malorni, W., Manic, G., Marine, JC., Martin, SJ., Martinou, JC., Medema, JP., Mehlen, P., Meier, P., Melino, S., Miao, EA., Molkentin, JD., Moll, UM., Muñoz-Pinedo, C., Nagata, S., Nuñez, G., Oberst, A., Oren, M., Overholtzer, M., Pagano, M., Panaretakis, T., Pasparakis, M., Penninger, JM., Pereira, DM., Pervaiz, S., Peter, ME., Piacentini, M., Pinton, P., Prehn, JHM., Puthalakath, H., Rabinovich, GA., Rehm, M., Rizzuto, R., Rodrigues, CMP., Rubinsztein, DC., Rudel, T., Ryan, KM., Sayan, E., Scorrano, L., Shao, F., Shi, Y., Silke, J., Simon, HU., Sistigu, A., Stockwell, BR., Strasser, A., Szabadkai, G., Tait, SWG., Tang, D., Tavernarakis, N., Thorburn, A., Tsujimoto, Y., Turk, B., Vanden Berghe, T., Vandenabeele, P., Vander Heiden, MG., Villunger, A., Virgin, HW., Vousden, KH., Vucic, D., Wagner, EF., Walczak, H., Wallach, D., Wang, Y., Wells, JA., Wood, W., Yuan, J., Zakeri, Z., Zhivotovsky, B., Zitvogel, L., Melino, G., Kroemer, G.
2018 Cbl-b deficiency provides protection against UVB-induced skin damage by modulating inflammatory gene signature. Cell Death Dis Singh, TP., Vieyra-Garcia, PA., Wagner, K., Penninger, J., Wolf, P.
2018 Depletion of angiotensin-converting enzyme 2 reduces brain serotonin and impairs the running-induced neurogenic response. Cell Mol Life Sci Klempin, F., Mosienko, V., Matthes, S., Villela, DC., Todiras, M., Penninger, JM., Bader, M., Santos, RAS., Alenina, N.
2018 Leukotriene B4 promotes neovascularization and macrophage recruitment in murine wet-type AMD models. JCI Insight Sasaki, F., Koga, T., Ohba, M., Saeki, K., Okuno, T., Ishikawa, K., Nakama, T., Nakao, S., Yoshida, S., Ishibashi, T., Ahmadieh, H., Kanavi, MR., Hafezi-Moghadam, A., Penninger, JM., Sonoda, KH., Yokomizo, T.
2018 The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature Cronin, SJF., Seehus, C., Weidinger, A., Talbot, S., Reissig, S., Seifert, M., Pierson, Y., McNeill, E., Longhi, MS., Turnes, BL., Kreslavsky, T., Kogler, M., Hoffmann, D., Ticevic, M., da Luz Scheffer, D., Tortola, L., Cikes, D., Jais, A., Rangachari, M., Rao, S., Paolino, M., Novatchkova, M., Aichinger, M., Barrett, L., Latremoliere, A., Wirnsberger, G., Lametschwandtner, G., Busslinger, M., Zicha, S., Latini, A., Robson, SC., Waisman, A., Andrews, N., Costigan, M., Channon, KM., Weiss, G., Kozlov, AV., Tebbe, M., Johnsson, K., Woolf, CJ., Penninger, JM.
2018 Coupling of bone resorption and formation by RANKL reverse signalling. Nature Ikebuchi, Y., Aoki, S., Honma, M., Hayashi, M., Sugamori, Y., Khan, M., Kariya, Y., Kato, G., Tabata, Y., Penninger, JM., Udagawa, N., Aoki, K., Suzuki, H.
2018 Pulmonary phagocyte-derived NPY controls the pathology of severe influenza virus infection. Nat Microbiol Fujiwara, S., Hoshizaki, M., Ichida, Y., Lex, D., Kuroda, E., Ishii, KJ., Magi, S., Okada, M., Takao, H., Gandou, M., Imai, H., Hara, R., Herzog, H., Yoshimura, A., Okamura, H., Penninger, JM., Slutsky, AS., Uhlig, S., Kuba, K., Imai, Y.
2018 RANKL and RANK: From Mammalian Physiology to Cancer Treatment. Trends Cell Biol Rao, S., Cronin, SJF., Sigl, V., Penninger, JM.
2018 The RNA helicase DDX3X is an essential mediator of innate antimicrobial immunity. PLoS Pathog Szappanos, D., Tschismarov, R., Perlot, T., Westermayer, S., Fischer, K., Platanitis, E., Kallinger, F., Novatchkova, M., Lassnig, C., Müller, M., Sexl, V., Bennett, KL., Foong-Sobis, M., Penninger, JM., Decker, T.
2018 Central RANK signalling in NPY neurons alters bone mass in male mice. Neuropeptides Lee, NJ., Clarke, IM., Enriquez, RF., Nagy, V., Penninger, J., Baldock, PA., Herzog, H.