Publications

Search Publications

Year	Title	Journal	Authors
2018	Morphological alterations of cultured human colorectal matched tumour and healthy organoids.	Oncotarget	Kashfi, SMH., Almozyan, S., Jinks, N., Koo, BK., Nateri, AS.
2017	Stem Cells in Repair of Gastrointestinal Epithelia.	Physiology (Bethesda)	Andersson-Rolf, A., Zilbauer, M., Koo, BK., Clevers, H.
2017	Human primary liver cancer-derived organoid cultures for disease modeling and drug screening.	Nat Med	Broutier, L., Mastrogiovanni, G., Verstegen, MM., Francies, HE., Gavarró, LM., Bradshaw, CR., Allen, GE., Arnes-Benito, R., Sidorova, O., Gaspersz, MP., Georgakopoulos, N., Koo, BK., Dietmann, S., Davies, SE., Praseedom, RK., Lieshout, R., IJzermans, JNM., Wigmore, SJ., Saeb-Parsy, K., Garnett, MJ., van der Laan, LJ., Huch, M.
2017	A Protocol for Multiple Gene Knockout in Mouse Small Intestinal Organoids Using a CRISPR-concatemer.	J Vis Exp	Merenda, A., Andersson-Rolf, A., Mustata, RC., Li, T., Kim, H., Koo, BK.
2017	One-step generation of conditional and reversible gene knockouts.	Nat Methods	Andersson-Rolf, A., Mustata, RC., Merenda, A., Kim, J., Perera, S., Grego, T., Andrews, K., Tremble, K., Silva, JC., Fink, J., Skarnes, WC., Koo, BK.
2017	Adult gastric stem cells and their niches.	Wiley Interdiscip Rev Dev Biol	Bartfeld, S., Koo, BK.
2017	DNA methylation defines regional identity of human intestinal epithelial organoids and undergoes dynamic changes during development.	Gut	Kraiczy, J., Nayak, KM., Howell, KJ., Ross, A., Forbester, J., Salvestrini, C., Mustata, R., Perkins, S., Andersson-Rolf, A., Leenen, E., Liebert, A., Vallier, L., Rosenstiel, PC., Stegle, O., Dougan, G., Heuschkel, R., Koo, BK., Zilbauer, M.
2017	Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium.	Nat Cell Biol	Turco, MY., Gardner, L., Hughes, J., Cindrova-Davies, T., Gomez, MJ., Farrell, L., Hollinshead, M., Marsh, SGE., Brosens, JJ., Critchley, HO., Simons, BD., Hemberger, M., Koo, BK., Moffett, A., Burton, GJ.
2017	DNA Methylation and Transcription Patterns in Intestinal Epithelial Cells From Pediatric Patients With Inflammatory Bowel Diseases Differentiate Disease Subtypes and Associate With Outcome.	Gastroenterology	Howell, KJ., Kraiczy, J., Nayak, KM., Gasparetto, M., Ross, A., Lee, C., Mak, TN., Koo, BK., Kumar, N., Lawley, T., Sinha, A., Rosenstiel, P., Heuschkel, R., Stegle, O., Zilbauer, M.
2016	Rapid, one-step generation of biallelic conditional gene knockouts.	BioRxiv	Andersson-Rolf A, Mustata RC, Merenda A, Perera S, Grego T, Kim J, Andrews K, Fink J, Skarnes WC, Koo BK.
2016	Simultaneous paralogue knockout using a CRISPR-concatemer in mouse small intestinal organoids.	Dev Biol	Andersson-Rolf, A., Merenda, A., Mustata, RC., Li, T., Dietmann, S., Koo, BK.
2016	Organoids: A new in vitro model system for biomedical science and disease modelling and promising source for cell-based transplantation.	Dev Biol	Koo, BK., Huch, M.
2016	Clonal Evolution of Stem Cells in the Gastrointestinal Tract.	Adv Exp Med Biol	Fink, J., Koo, BK.
2016	Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation.	Nat Protoc	Broutier, L., Andersson-Rolf, A., Hindley, CJ., Boj, SF., Clevers, H., Koo, BK., Huch, M.
2015	Stem cell-derived organoid cultures and genome editing tools.	Cell Gene Therapy Insights	Andersson-Rolf A, Koo BK
2015	Adult stem cell lineage tracing and deep tissue imaging.	BMB Rep	Fink, J., Andersson-Rolf, A., Koo, BK.
2015	Modeling mouse and human development using organoid cultures.	Development	Huch, M., Koo, BK.
2015	Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts.	Cell Stem Cell	Schuijers, J., Junker, JP., Mokry, M., Hatzis, P., Koo, BK., Sasselli, V., van der Flier, LG., Cuppen, E., van Oudenaarden, A., Clevers, H.
2015	Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia.	Proc Natl Acad Sci U S A	Koo, BK., van Es, JH., van den Born, M., Clevers, H.
2014	A video protocol of retroviral infection in primary intestinal organoid culture.	J Vis Exp	Andersson-Rolf, A., Fink, J., Mustata, RC., Koo, BK.