2019 |
Mouse Models of Human Gastric Cancer Subtypes with Stomach-Specific CreERT2-Mediated Pathway Alterations.
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Gastroenterology |
Seidlitz, T., Chen, YT., Uhlemann, H., Schölch, S., Kochall, S., Merker, SR., Klimova, A., Hennig, A., Schweitzer, C., Pape, K., Baretton, GB., Welsch, T., Aust, DE., Weitz, J., Koo, BK., Stange, DE. |
2019 |
Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells.
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Cell Stem Cell |
Han, S., Fink, J., Jörg, DJ., Lee, E., Yum, MK., Chatzeli, L., Merker, SR., Josserand, M., Trendafilova, T., Andersson-Rolf, A., Dabrowska, C., Kim, H., Naumann, R., Lee, JH., Sasaki, N., Mort, RL., Basak, O., Clevers, H., Stange, DE., Philpott, A., Kim, JK., Simons, BD., Koo, BK. |
2019 |
Lineage Tracing: Computational Reconstruction Goes Beyond the Limit of Imaging.
|
Mol Cells |
Wu, SS., Lee, JH., Koo, BK. |
2019 |
Human gastric cancer modelling using organoids.
|
Gut |
Seidlitz, T., Merker, SR., Rothe, A., Zakrzewski, F., von Neubeck, C., Grützmann, K., Sommer, U., Schweitzer, C., Schölch, S., Uhlemann, H., Gaebler, AM., Werner, K., Krause, M., Baretton, GB., Welsch, T., Koo, BK., Aust, DE., Klink, B., Weitz, J., Stange, DE. |
2019 |
Modeling Host-Virus Interactions in Viral Infectious Diseases Using Stem-Cell-Derived Systems and CRISPR/Cas9 Technology.
|
Viruses |
Kim, J., Koo, BK., Yoon, KJ. |
2019 |
DNA methylation defines regional identity of human intestinal epithelial organoids and undergoes dynamic changes during development.
|
Gut |
Kraiczy, J., Nayak, KM., Howell, KJ., Ross, A., Forbester, J., Salvestrini, C., Mustata, R., Perkins, S., Andersson-Rolf, A., Leenen, E., Liebert, A., Vallier, L., Rosenstiel, PC., Stegle, O., Dougan, G., Heuschkel, R., Koo, BK., Zilbauer, M. |
2019 |
A ZNRF3-dependent Wnt/?-catenin signaling gradient is required for adrenal homeostasis.
|
Genes Dev |
Basham, KJ., Rodriguez, S., Turcu, AF., Lerario, AM., Logan, CY., Rysztak, MR., Gomez-Sanchez, CE., Breault, DT., Koo, BK., Clevers, H., Nusse, R., Val, P., Hammer, GD. |
2018 |
DNA Methylation and Transcription Patterns in Intestinal Epithelial Cells From Pediatric Patients With Inflammatory Bowel Diseases Differentiate Disease Subtypes and Associate With Outcome.
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Gastroenterology |
Howell, KJ., Kraiczy, J., Nayak, KM., Gasparetto, M., Ross, A., Lee, C., Mak, TN., Koo, BK., Kumar, N., Lawley, T., Sinha, A., Rosenstiel, P., Heuschkel, R., Stegle, O., Zilbauer, M. |
2018 |
How to create state-of-the-art genetic model systems: strategies for optimal CRISPR-mediated genome editing.
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Nucleic Acids Res |
Bollen, Y., Post, J., Koo, BK., Snippert, HJG. |
2018 |
Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis.
|
Cell |
Nanki, K., Toshimitsu, K., Takano, A., Fujii, M., Shimokawa, M., Ohta, Y., Matano, M., Seino, T., Nishikori, S., Ishikawa, K., Kawasaki, K., Togasaki, K., Takahashi, S., Sukawa, Y., Ishida, H., Sugimoto, S., Kawakubo, H., Kim, J., Kitagawa, Y., Sekine, S., Koo, BK., Kanai, T., Sato, T. |
2018 |
Generation of FLIP and FLIP-FlpE Targeting Vectors for Biallelic Conditional and Reversible Gene Knockouts in Mouse and Human Cells.
|
Methods Mol Biol |
Koo, BK. |
2018 |
Tales from the crypt: intestinal niche signals in tissue renewal, plasticity and cancer.
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Open Biol |
Spit, M., Koo, BK., Maurice, MM. |
2018 |
ZNRF3 functions in mammalian sex determination by inhibiting canonical WNT signaling.
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Proc Natl Acad Sci U S A |
Harris, A., Siggers, P., Corrochano, S., Warr, N., Sagar, D., Grimes, DT., Suzuki, M., Burdine, RD., Cong, F., Koo, BK., Clevers, H., Stévant, I., Nef, S., Wells, S., Brauner, R., Ben Rhouma, B., Belguith, N., Eozenou, C., Bignon-Topalovic, J., Bashamboo, A., McElreavey, K., Greenfield, A. |
2018 |
Morphological alterations of cultured human colorectal matched tumour and healthy organoids.
|
Oncotarget |
Kashfi, SMH., Almozyan, S., Jinks, N., Koo, BK., Nateri, AS. |
2017 |
Human primary liver cancer-derived organoid cultures for disease modeling and drug screening.
|
Nat Med |
Broutier, L., Mastrogiovanni, G., Verstegen, MM., Francies, HE., Gavarró, LM., Bradshaw, CR., Allen, GE., Arnes-Benito, R., Sidorova, O., Gaspersz, MP., Georgakopoulos, N., Koo, BK., Dietmann, S., Davies, SE., Praseedom, RK., Lieshout, R., IJzermans, JNM., Wigmore, SJ., Saeb-Parsy, K., Garnett, MJ., van der Laan, LJ., Huch, M. |
2017 |
Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium.
|
Nat Cell Biol |
Turco, MY., Gardner, L., Hughes, J., Cindrova-Davies, T., Gomez, MJ., Farrell, L., Hollinshead, M., Marsh, SGE., Brosens, JJ., Critchley, HO., Simons, BD., Hemberger, M., Koo, BK., Moffett, A., Burton, GJ. |
2017 |
Stem Cells in Repair of Gastrointestinal Epithelia.
|
Physiology (Bethesda) |
Andersson-Rolf, A., Zilbauer, M., Koo, BK., Clevers, H. |
2017 |
A Protocol for Multiple Gene Knockout in Mouse Small Intestinal Organoids Using a CRISPR-concatemer.
|
J Vis Exp |
Merenda, A., Andersson-Rolf, A., Mustata, RC., Li, T., Kim, H., Koo, BK. |
2017 |
One-step generation of conditional and reversible gene knockouts.
|
Nat Methods |
Andersson-Rolf, A., Mustata, RC., Merenda, A., Kim, J., Perera, S., Grego, T., Andrews, K., Tremble, K., Silva, JC., Fink, J., Skarnes, WC., Koo, BK. |
2017 |
Adult gastric stem cells and their niches.
|
Wiley Interdiscip Rev Dev Biol |
Bartfeld, S., Koo, BK. |