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Publications

Year Title Journal Authors
2019 Mouse Models of Human Gastric Cancer Subtypes with Stomach-Specific CreERT2-Mediated Pathway Alterations. Gastroenterology Seidlitz, T., Chen, YT., Uhlemann, H., Schölch, S., Kochall, S., Merker, SR., Klimova, A., Hennig, A., Schweitzer, C., Pape, K., Baretton, GB., Welsch, T., Aust, DE., Weitz, J., Koo, BK., Stange, DE.
2019 Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells. Cell Stem Cell Han, S., Fink, J., Jörg, DJ., Lee, E., Yum, MK., Chatzeli, L., Merker, SR., Josserand, M., Trendafilova, T., Andersson-Rolf, A., Dabrowska, C., Kim, H., Naumann, R., Lee, JH., Sasaki, N., Mort, RL., Basak, O., Clevers, H., Stange, DE., Philpott, A., Kim, JK., Simons, BD., Koo, BK.
2019 Lineage Tracing: Computational Reconstruction Goes Beyond the Limit of Imaging. Mol Cells Wu, SS., Lee, JH., Koo, BK.
2019 Human gastric cancer modelling using organoids. Gut Seidlitz, T., Merker, SR., Rothe, A., Zakrzewski, F., von Neubeck, C., Grützmann, K., Sommer, U., Schweitzer, C., Schölch, S., Uhlemann, H., Gaebler, AM., Werner, K., Krause, M., Baretton, GB., Welsch, T., Koo, BK., Aust, DE., Klink, B., Weitz, J., Stange, DE.
2019 Modeling Host-Virus Interactions in Viral Infectious Diseases Using Stem-Cell-Derived Systems and CRISPR/Cas9 Technology. Viruses Kim, J., Koo, BK., Yoon, KJ.
2019 DNA methylation defines regional identity of human intestinal epithelial organoids and undergoes dynamic changes during development. Gut Kraiczy, J., Nayak, KM., Howell, KJ., Ross, A., Forbester, J., Salvestrini, C., Mustata, R., Perkins, S., Andersson-Rolf, A., Leenen, E., Liebert, A., Vallier, L., Rosenstiel, PC., Stegle, O., Dougan, G., Heuschkel, R., Koo, BK., Zilbauer, M.
2019 A ZNRF3-dependent Wnt/?-catenin signaling gradient is required for adrenal homeostasis. Genes Dev Basham, KJ., Rodriguez, S., Turcu, AF., Lerario, AM., Logan, CY., Rysztak, MR., Gomez-Sanchez, CE., Breault, DT., Koo, BK., Clevers, H., Nusse, R., Val, P., Hammer, GD.
2018 DNA Methylation and Transcription Patterns in Intestinal Epithelial Cells From Pediatric Patients With Inflammatory Bowel Diseases Differentiate Disease Subtypes and Associate With Outcome. Gastroenterology Howell, KJ., Kraiczy, J., Nayak, KM., Gasparetto, M., Ross, A., Lee, C., Mak, TN., Koo, BK., Kumar, N., Lawley, T., Sinha, A., Rosenstiel, P., Heuschkel, R., Stegle, O., Zilbauer, M.
2018 How to create state-of-the-art genetic model systems: strategies for optimal CRISPR-mediated genome editing. Nucleic Acids Res Bollen, Y., Post, J., Koo, BK., Snippert, HJG.
2018 Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis. Cell Nanki, K., Toshimitsu, K., Takano, A., Fujii, M., Shimokawa, M., Ohta, Y., Matano, M., Seino, T., Nishikori, S., Ishikawa, K., Kawasaki, K., Togasaki, K., Takahashi, S., Sukawa, Y., Ishida, H., Sugimoto, S., Kawakubo, H., Kim, J., Kitagawa, Y., Sekine, S., Koo, BK., Kanai, T., Sato, T.
2018 Generation of FLIP and FLIP-FlpE Targeting Vectors for Biallelic Conditional and Reversible Gene Knockouts in Mouse and Human Cells. Methods Mol Biol Koo, BK.
2018 Tales from the crypt: intestinal niche signals in tissue renewal, plasticity and cancer. Open Biol Spit, M., Koo, BK., Maurice, MM.
2018 ZNRF3 functions in mammalian sex determination by inhibiting canonical WNT signaling. Proc Natl Acad Sci U S A Harris, A., Siggers, P., Corrochano, S., Warr, N., Sagar, D., Grimes, DT., Suzuki, M., Burdine, RD., Cong, F., Koo, BK., Clevers, H., Stévant, I., Nef, S., Wells, S., Brauner, R., Ben Rhouma, B., Belguith, N., Eozenou, C., Bignon-Topalovic, J., Bashamboo, A., McElreavey, K., Greenfield, A.
2018 Morphological alterations of cultured human colorectal matched tumour and healthy organoids. Oncotarget Kashfi, SMH., Almozyan, S., Jinks, N., Koo, BK., Nateri, AS.
2017 Human primary liver cancer-derived organoid cultures for disease modeling and drug screening. Nat Med Broutier, L., Mastrogiovanni, G., Verstegen, MM., Francies, HE., Gavarró, LM., Bradshaw, CR., Allen, GE., Arnes-Benito, R., Sidorova, O., Gaspersz, MP., Georgakopoulos, N., Koo, BK., Dietmann, S., Davies, SE., Praseedom, RK., Lieshout, R., IJzermans, JNM., Wigmore, SJ., Saeb-Parsy, K., Garnett, MJ., van der Laan, LJ., Huch, M.
2017 Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium. Nat Cell Biol Turco, MY., Gardner, L., Hughes, J., Cindrova-Davies, T., Gomez, MJ., Farrell, L., Hollinshead, M., Marsh, SGE., Brosens, JJ., Critchley, HO., Simons, BD., Hemberger, M., Koo, BK., Moffett, A., Burton, GJ.
2017 Stem Cells in Repair of Gastrointestinal Epithelia. Physiology (Bethesda) Andersson-Rolf, A., Zilbauer, M., Koo, BK., Clevers, H.
2017 A Protocol for Multiple Gene Knockout in Mouse Small Intestinal Organoids Using a CRISPR-concatemer. J Vis Exp Merenda, A., Andersson-Rolf, A., Mustata, RC., Li, T., Kim, H., Koo, BK.
2017 One-step generation of conditional and reversible gene knockouts. Nat Methods Andersson-Rolf, A., Mustata, RC., Merenda, A., Kim, J., Perera, S., Grego, T., Andrews, K., Tremble, K., Silva, JC., Fink, J., Skarnes, WC., Koo, BK.
2017 Adult gastric stem cells and their niches. Wiley Interdiscip Rev Dev Biol Bartfeld, S., Koo, BK.