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Publications

Year Title Journal Authors
2017 A Protocol for Multiple Gene Knockout in Mouse Small Intestinal Organoids Using a CRISPR-concatemer. J Vis Exp Merenda, A., Andersson-Rolf, A., Mustata, RC., Li, T., Kim, H., Koo, BK.
2017 One-step generation of conditional and reversible gene knockouts. Nat Methods Andersson-Rolf, A., Mustata, RC., Merenda, A., Kim, J., Perera, S., Grego, T., Andrews, K., Tremble, K., Silva, JC., Fink, J., Skarnes, WC., Koo, BK.
2017 Adult gastric stem cells and their niches. Wiley Interdiscip Rev Dev Biol Bartfeld, S., Koo, BK.
2017 Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium. Nat Cell Biol Turco, MY., Gardner, L., Hughes, J., Cindrova-Davies, T., Gomez, MJ., Farrell, L., Hollinshead, M., Marsh, SGE., Brosens, JJ., Critchley, HO., Simons, BD., Hemberger, M., Koo, BK., Moffett, A., Burton, GJ.
2017 Stem Cells in Repair of Gastrointestinal Epithelia. Physiology (Bethesda) Andersson-Rolf, A., Zilbauer, M., Koo, BK., Clevers, H.
2016 Rapid, one-step generation of biallelic conditional gene knockouts. BioRxiv Andersson-Rolf A, Mustata RC, Merenda A, Perera S, Grego T, Kim J, Andrews K, Fink J, Skarnes WC, Koo BK.
2016 Simultaneous paralogue knockout using a CRISPR-concatemer in mouse small intestinal organoids. Dev Biol Andersson-Rolf, A., Merenda, A., Mustata, RC., Li, T., Dietmann, S., Koo, BK.
2016 Organoids: A new in vitro model system for biomedical science and disease modelling and promising source for cell-based transplantation. Dev Biol Koo, BK., Huch, M.
2016 Clonal Evolution of Stem Cells in the Gastrointestinal Tract. Adv Exp Med Biol Fink, J., Koo, BK.
2016 Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation. Nat Protoc Broutier, L., Andersson-Rolf, A., Hindley, CJ., Boj, SF., Clevers, H., Koo, BK., Huch, M.
2015 Stem cell-derived organoid cultures and genome editing tools. Cell Gene Therapy Insights Andersson-Rolf A, Koo BK
2015 Adult stem cell lineage tracing and deep tissue imaging. BMB Rep Fink, J., Andersson-Rolf, A., Koo, BK.
2015 Modeling mouse and human development using organoid cultures. Development Huch, M., Koo, BK.
2015 Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia. Proc Natl Acad Sci U S A Koo, BK., van Es, JH., van den Born, M., Clevers, H.
2015 Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts. Cell Stem Cell Schuijers, J., Junker, JP., Mokry, M., Hatzis, P., Koo, BK., Sasselli, V., van der Flier, LG., Cuppen, E., van Oudenaarden, A., Clevers, H.
2014 A video protocol of retroviral infection in primary intestinal organoid culture. J Vis Exp Andersson-Rolf, A., Fink, J., Mustata, RC., Koo, BK.
2014 Stem cells marked by the R-spondin receptor LGR5. Gastroenterology Koo, BK., Clevers, H.
2013 Retroviral gene expression control in primary organoid cultures. Curr Protoc Stem Cell Biol Koo, BK., Sasselli, V., Clevers, H.
2013 Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. Cell Stem Cell Schwank, G., Koo, BK., Sasselli, V., Dekkers, JF., Heo, I., Demircan, T., Sasaki, N., Boymans, S., Cuppen, E., van der Ent, CK., Nieuwenhuis, EE., Beekman, JM., Clevers, H.
2013 Generation of BAC transgenic epithelial organoids. PLoS One Schwank, G., Andersson-Rolf, A., Koo, BK., Sasaki, N., Clevers, H.