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Publications

Year Title Journal Authors
2020 Human Microphysiological Models of Intestinal Tissue and Gut Microbiome. Front Bioeng Biotechnol Steinway, SN., Saleh, J., Koo, BK., Delacour, D., Kim, DH.
2020 Human organoids: model systems for human biology and medicine. Nat Rev Mol Cell Biol Kim, J., Koo, BK., Knoblich, JA.
2020 Norovirus Replication in Human Intestinal Epithelial Cells Is Restricted by the Interferon-Induced JAK/STAT Signaling Pathway and RNA Polymerase II-Mediated Transcriptional Responses. mBio Hosmillo, M., Chaudhry, Y., Nayak, K., Sorgeloos, F., Koo, BK., Merenda, A., Lillestol, R., Drumright, L., Zilbauer, M., Goodfellow, I.
2020 Inflammatory Signals Induce AT2 Cell-Derived Damage-Associated Transient Progenitors that Mediate Alveolar Regeneration. Cell Stem Cell Choi, J., Park, JE., Tsagkogeorga, G., Yanagita, M., Koo, BK., Han, N., Lee, JH.
2020 Deficiency of the SMOC2 matricellular protein impairs bone healing and produces age-dependent bone loss. Sci Rep Morkmued, S., Clauss, F., Schuhbaur, B., Fraulob, V., Mathieu, E., Hemmerlé, J., Clevers, H., Koo, BK., Dollé, P., Bloch-Zupan, A., Niederreither, K.
2020 A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis. Nat Commun Tsukiyama, T., Zou, J., Kim, J., Ogamino, S., Shino, Y., Masuda, T., Merenda, A., Matsumoto, M., Fujioka, Y., Hirose, T., Terai, S., Takahashi, H., Ishitani, T., Nakayama, KI., Ohba, Y., Koo, BK., Hatakeyama, S.
2020 RNF43 truncations trap CK1 to drive niche-independent self-renewal in cancer. EMBO J Spit, M., Fenderico, N., Jordens, I., Radaszkiewicz, T., Lindeboom, RG., Bugter, JM., Cristobal, A., Ootes, L., van Osch, M., Janssen, E., Boonekamp, KE., Hanakova, K., Potesil, D., Zdrahal, Z., Boj, SF., Medema, JP., Bryja, V., Koo, BK., Vermeulen, M., Maurice, MM.
2020 Gastric organoids-an in vitro model system for the study of gastric development and road to personalized medicine. Cell Death Differ Seidlitz, T., Koo, BK., Stange, DE.
2019 Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells. Cell Stem Cell Han, S., Fink, J., Jörg, DJ., Lee, E., Yum, MK., Chatzeli, L., Merker, SR., Josserand, M., Trendafilova, T., Andersson-Rolf, A., Dabrowska, C., Kim, H., Naumann, R., Lee, JH., Sasaki, N., Mort, RL., Basak, O., Clevers, H., Stange, DE., Philpott, A., Kim, JK., Simons, BD., Koo, BK.
2019 Lineage Tracing: Computational Reconstruction Goes Beyond the Limit of Imaging. Mol Cells Wu, SS., Lee, JH., Koo, BK.
2019 Human gastric cancer modelling using organoids. Gut Seidlitz, T., Merker, SR., Rothe, A., Zakrzewski, F., von Neubeck, C., Grützmann, K., Sommer, U., Schweitzer, C., Schölch, S., Uhlemann, H., Gaebler, AM., Werner, K., Krause, M., Baretton, GB., Welsch, T., Koo, BK., Aust, DE., Klink, B., Weitz, J., Stange, DE.
2019 Modeling Host-Virus Interactions in Viral Infectious Diseases Using Stem-Cell-Derived Systems and CRISPR/Cas9 Technology. Viruses Kim, J., Koo, BK., Yoon, KJ.
2019 Mouse Models of Human Gastric Cancer Subtypes With Stomach-Specific CreERT2-Mediated Pathway Alterations. Gastroenterology Seidlitz, T., Chen, YT., Uhlemann, H., Schölch, S., Kochall, S., Merker, SR., Klimova, A., Hennig, A., Schweitzer, C., Pape, K., Baretton, GB., Welsch, T., Aust, DE., Weitz, J., Koo, BK., Stange, DE.
2019 DNA methylation defines regional identity of human intestinal epithelial organoids and undergoes dynamic changes during development. Gut Kraiczy, J., Nayak, KM., Howell, KJ., Ross, A., Forbester, J., Salvestrini, C., Mustata, R., Perkins, S., Andersson-Rolf, A., Leenen, E., Liebert, A., Vallier, L., Rosenstiel, PC., Stegle, O., Dougan, G., Heuschkel, R., Koo, BK., Zilbauer, M.
2019 A ZNRF3-dependent Wnt/β-catenin signaling gradient is required for adrenal homeostasis. Genes Dev Basham, KJ., Rodriguez, S., Turcu, AF., Lerario, AM., Logan, CY., Rysztak, MR., Gomez-Sanchez, CE., Breault, DT., Koo, BK., Clevers, H., Nusse, R., Val, P., Hammer, GD.
2018 DNA Methylation and Transcription Patterns in Intestinal Epithelial Cells From Pediatric Patients With Inflammatory Bowel Diseases Differentiate Disease Subtypes and Associate With Outcome. Gastroenterology Howell, KJ., Kraiczy, J., Nayak, KM., Gasparetto, M., Ross, A., Lee, C., Mak, TN., Koo, BK., Kumar, N., Lawley, T., Sinha, A., Rosenstiel, P., Heuschkel, R., Stegle, O., Zilbauer, M.
2018 How to create state-of-the-art genetic model systems: strategies for optimal CRISPR-mediated genome editing. Nucleic Acids Res Bollen, Y., Post, J., Koo, BK., Snippert, HJG.
2018 Morphological alterations of cultured human colorectal matched tumour and healthy organoids. Oncotarget Kashfi, SMH., Almozyan, S., Jinks, N., Koo, BK., Nateri, AS.
2018 Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis. Cell Nanki, K., Toshimitsu, K., Takano, A., Fujii, M., Shimokawa, M., Ohta, Y., Matano, M., Seino, T., Nishikori, S., Ishikawa, K., Kawasaki, K., Togasaki, K., Takahashi, S., Sukawa, Y., Ishida, H., Sugimoto, S., Kawakubo, H., Kim, J., Kitagawa, Y., Sekine, S., Koo, BK., Kanai, T., Sato, T.
2018 Generation of FLIP and FLIP-FlpE Targeting Vectors for Biallelic Conditional and Reversible Gene Knockouts in Mouse and Human Cells. Methods Mol Biol Koo, BK.