Publications

Search Publications

Year	Title	Journal	Authors
2020	Human Microphysiological Models of Intestinal Tissue and Gut Microbiome.	Front Bioeng Biotechnol	Steinway, SN., Saleh, J., Koo, BK., Delacour, D., Kim, DH.
2020	Human organoids: model systems for human biology and medicine.	Nat Rev Mol Cell Biol	Kim, J., Koo, BK., Knoblich, JA.
2020	Norovirus Replication in Human Intestinal Epithelial Cells Is Restricted by the Interferon-Induced JAK/STAT Signaling Pathway and RNA Polymerase II-Mediated Transcriptional Responses.	mBio	Hosmillo, M., Chaudhry, Y., Nayak, K., Sorgeloos, F., Koo, BK., Merenda, A., Lillestol, R., Drumright, L., Zilbauer, M., Goodfellow, I.
2020	Inflammatory Signals Induce AT2 Cell-Derived Damage-Associated Transient Progenitors that Mediate Alveolar Regeneration.	Cell Stem Cell	Choi, J., Park, JE., Tsagkogeorga, G., Yanagita, M., Koo, BK., Han, N., Lee, JH.
2020	Deficiency of the SMOC2 matricellular protein impairs bone healing and produces age-dependent bone loss.	Sci Rep	Morkmued, S., Clauss, F., Schuhbaur, B., Fraulob, V., Mathieu, E., Hemmerlé, J., Clevers, H., Koo, BK., Dollé, P., Bloch-Zupan, A., Niederreither, K.
2020	A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis.	Nat Commun	Tsukiyama, T., Zou, J., Kim, J., Ogamino, S., Shino, Y., Masuda, T., Merenda, A., Matsumoto, M., Fujioka, Y., Hirose, T., Terai, S., Takahashi, H., Ishitani, T., Nakayama, KI., Ohba, Y., Koo, BK., Hatakeyama, S.
2020	RNF43 truncations trap CK1 to drive niche-independent self-renewal in cancer.	EMBO J	Spit, M., Fenderico, N., Jordens, I., Radaszkiewicz, T., Lindeboom, RG., Bugter, JM., Cristobal, A., Ootes, L., van Osch, M., Janssen, E., Boonekamp, KE., Hanakova, K., Potesil, D., Zdrahal, Z., Boj, SF., Medema, JP., Bryja, V., Koo, BK., Vermeulen, M., Maurice, MM.
2020	Gastric organoids-an in vitro model system for the study of gastric development and road to personalized medicine.	Cell Death Differ	Seidlitz, T., Koo, BK., Stange, DE.
2019	Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells.	Cell Stem Cell	Han, S., Fink, J., Jörg, DJ., Lee, E., Yum, MK., Chatzeli, L., Merker, SR., Josserand, M., Trendafilova, T., Andersson-Rolf, A., Dabrowska, C., Kim, H., Naumann, R., Lee, JH., Sasaki, N., Mort, RL., Basak, O., Clevers, H., Stange, DE., Philpott, A., Kim, JK., Simons, BD., Koo, BK.
2019	Lineage Tracing: Computational Reconstruction Goes Beyond the Limit of Imaging.	Mol Cells	Wu, SS., Lee, JH., Koo, BK.
2019	Human gastric cancer modelling using organoids.	Gut	Seidlitz, T., Merker, SR., Rothe, A., Zakrzewski, F., von Neubeck, C., Grützmann, K., Sommer, U., Schweitzer, C., Schölch, S., Uhlemann, H., Gaebler, AM., Werner, K., Krause, M., Baretton, GB., Welsch, T., Koo, BK., Aust, DE., Klink, B., Weitz, J., Stange, DE.
2019	Modeling Host-Virus Interactions in Viral Infectious Diseases Using Stem-Cell-Derived Systems and CRISPR/Cas9 Technology.	Viruses	Kim, J., Koo, BK., Yoon, KJ.
2019	Mouse Models of Human Gastric Cancer Subtypes With Stomach-Specific CreERT2-Mediated Pathway Alterations.	Gastroenterology	Seidlitz, T., Chen, YT., Uhlemann, H., Schölch, S., Kochall, S., Merker, SR., Klimova, A., Hennig, A., Schweitzer, C., Pape, K., Baretton, GB., Welsch, T., Aust, DE., Weitz, J., Koo, BK., Stange, DE.
2019	DNA methylation defines regional identity of human intestinal epithelial organoids and undergoes dynamic changes during development.	Gut	Kraiczy, J., Nayak, KM., Howell, KJ., Ross, A., Forbester, J., Salvestrini, C., Mustata, R., Perkins, S., Andersson-Rolf, A., Leenen, E., Liebert, A., Vallier, L., Rosenstiel, PC., Stegle, O., Dougan, G., Heuschkel, R., Koo, BK., Zilbauer, M.
2019	A ZNRF3-dependent Wnt/β-catenin signaling gradient is required for adrenal homeostasis.	Genes Dev	Basham, KJ., Rodriguez, S., Turcu, AF., Lerario, AM., Logan, CY., Rysztak, MR., Gomez-Sanchez, CE., Breault, DT., Koo, BK., Clevers, H., Nusse, R., Val, P., Hammer, GD.
2018	DNA Methylation and Transcription Patterns in Intestinal Epithelial Cells From Pediatric Patients With Inflammatory Bowel Diseases Differentiate Disease Subtypes and Associate With Outcome.	Gastroenterology	Howell, KJ., Kraiczy, J., Nayak, KM., Gasparetto, M., Ross, A., Lee, C., Mak, TN., Koo, BK., Kumar, N., Lawley, T., Sinha, A., Rosenstiel, P., Heuschkel, R., Stegle, O., Zilbauer, M.
2018	How to create state-of-the-art genetic model systems: strategies for optimal CRISPR-mediated genome editing.	Nucleic Acids Res	Bollen, Y., Post, J., Koo, BK., Snippert, HJG.
2018	Morphological alterations of cultured human colorectal matched tumour and healthy organoids.	Oncotarget	Kashfi, SMH., Almozyan, S., Jinks, N., Koo, BK., Nateri, AS.
2018	Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis.	Cell	Nanki, K., Toshimitsu, K., Takano, A., Fujii, M., Shimokawa, M., Ohta, Y., Matano, M., Seino, T., Nishikori, S., Ishikawa, K., Kawasaki, K., Togasaki, K., Takahashi, S., Sukawa, Y., Ishida, H., Sugimoto, S., Kawakubo, H., Kim, J., Kitagawa, Y., Sekine, S., Koo, BK., Kanai, T., Sato, T.
2018	Generation of FLIP and FLIP-FlpE Targeting Vectors for Biallelic Conditional and Reversible Gene Knockouts in Mouse and Human Cells.	Methods Mol Biol	Koo, BK.