mechanisms of plasticity after brain injury
Formerly perceived as a hardwired rigid structure, constrained by stable networks, the adult mammalian brain is now known to be malleable, in particular, in the aftermath of an injury. The Grade lab investigates the fundamental biological principles of neural circuit plasticity upon brain injury or disease, using mouse as a mammalian model system. We take a system-wide approach to allow an understanding of complex interactions at the neural networks level, within the biological system. Our goal is to uncover the magnitude and mechanistic basis of induced plasticity which will illuminate potential intervention approaches for brain injury or neurodegenerative conditions.
Keywords: brain injury, connectivity, neural networks, circuit plasticity, remodeling
The Grade Group will start at IMBA in February 2020. Contact Sofia Grade: send e-mail