mechanisms of plasticity after brain injury
Formerly perceived as a hardwired rigid structure, constrained by stable networks, the adult mammalian brain is now known to be malleable, in particular, in the aftermath of an injury. In stroke, spared circuits can take over functions previously executed by those lost, and neurodegenerative disease can remain unnoticed for years. The Grade lab investigates the fundamental biological principles of neural circuit plasticity upon brain injury, using mouse as a mammalian model system. We take a system-wide approach to allow a deeper understanding of complex interactions, at the neural network level, within the biological system. As we shed light into the magnitude and mechanistic basis of induced plasticity, we advance our understanding of its potential for intervention approaches to cope with brain injury or neurodegenerative conditions.
Keywords: brain injury, structural plasticity, adaptive remodeling, neural networks, brain connectivity
The Grade Group will start at IMBA in February 2020