Proliferating cells undergo dramatic reorganization during mitosis to properly partition their organelles to daughter cells. Upon mitotic entry, interphase organelles transiently acquire a form that can be mechanically segregated to the two nascent daughter cells. For instance, mitotic chromosomes form non-membrane-bounded bodies, separated from the cytoplasm by regulated surface properties. These organelles subsequently restore their interphase morphologies during mitotic exit. Our group investigates how human cells reorganize internal components during the cell cycle to ensure their precise distribution. We use multi-disciplinary approaches, including cell biology, biophysics, biochemistry, and computational biology. Our goal is to understand how molecular components reshape macroscopic cell structures through self-organization.
Keywords: mitosis, chromosomes, cell organelles, high-content screening, computer vision, biophysics