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Frauen und Lungenkrebs – Lang vermuteter Zusammenhang zwischen weiblichen Sexhormonen und Krebsentstehung erstmals aufgedeckt. Bei der Behandlung von Lungentumoren mit Denosumab (bei der untere Reihe wurde RANK/RANKL blockiert, in der oberen Reihe ist der Signalweg aktiv) konnte ein Fortschreiten der Krankheit signifikant verringert werden. (c)IMBA
Taking screening methods to the next level: CRISPR-UMI relies on the addition of a high complexity barcoding system – or Unique Molecular Identifier (UMI) – that uniquely marks each mutant clone within a population, thus it allows tracking single mutants within a population of cells.
HAPLOBANK - a biobank of reversible mutant embryonic stem cells: Haplobank contains over 100,000 mutated, conditional mouse embryonic stem cell lines, targeting about 70% of the protein-coding genome.
IMBA group leader Stefan Ameres and Lexogen CEO Alexander Seitz
IMBA Group leader Stefan Ameres and Lexogen CEO ALexander Seitz
Glycosylation: Mapping uncharted territory: SugarQb is a platform that enables global insights into protein glycosylation and glycan modifications in biological systems. (c)IMBA
Ricin only lethal in combination with sugar: Jasmin Taubenschmid, first author of the study
How cells hack their own genes: Image of a developing drosophila ovary with DNA stained in blue. Using staining for specific proteins researchers could locate the gene hacking events to the white foci in the germline nuclei. (c)IMBA
Sabrina Ladstätter wins ÖAW best pager award. Image: Sabrina Ladstätter, OeAW best paper awardee
IMBA-Senior Group Leader Daniel Gerlich elected new EMBO member. Image: Daniel Gerlich
Splitting cells: How a dynamic protein machinery executes 'the final cut'. Image: ESCRT model figure: VPS4 mediates turnover of ESCRT subunits with growing and constricting polymers (c)IMBA
Building better brains: A bioengineered upgrade for organoids. Image: Bioengineered organoids or so called enCORs are supported by a floating scaffold of PLGA-fiber microfilaments.
Connecting brain regions in a dish - a new organoid technology to detect malfunctions in the brain. Image: The novel organoid "fusion" technique is a new method to combine different brain tissues in a dish to observe complex interactions, such as cell migration and axon growth, between different developing brain regions.
Unique genome architectures after fertilisation in single-cell embryos. Image: Chromatin structures of male and female nuclei are distinct from another and strikingly different from other any other interphase cells.
IMBA Research Report 2015 (5,7 MB; download as pdf)
IMBA Research Report 2014 (4 MB; download as pdf)
IMBA Research Report 2013 (5 MB; download as pdf)
IMBA Research Report 2012 (9 MB; download as pdf)
IMBA Research Report 2011 (9 MB; download as PDF)
IMBA Research Report 2010 (6 MB; download as PDF)
IMBA Research Report 2009 (11MB; download as PDF)
IMBA Research Report 2008 (15MB; download as PDF)
IMBA Research Report 2007 (6,5 MB; download as PDF)
IMBA Research Report 2006 (10 MB; download as PDF)
IMBA Research Report 2005 (3,5 MB; download as PDF)
IMBA Research Report 2004 (6,3 MB; download as PDF)
Josef Penninger, Scientific Director (c)IMBA/Michael Sazel
Jürgen Knoblich, Deputy Scientific Director (c)IMBA/Michael Sazel
Michael Krebs, Administrative Director (c)IMBA/Michael Sazel