COVID-19 befallene Blutgefäß-Organoide. Duch den Wirkstoff hrACE2 konnte der Virenbefall signifikant verringert werden. (c)IMBA/Kulcsar
Johanna Gassler, Doktorandin am IMBA, erhält eine der begehrten LOREAL Stipendium
An egg chamber of a Drosophila melanogaster ovary expressing Nxf3 tagged with GFP (in green). Nxf3 localizes to piRNA source loci the nucleus as well as piRNA processing sites in the cytoplasm. DNA is stained in blue, while the nuclear pore marker (WGA) is in magenta. (c)IMBA
Diabetic blood vessel changes in patients and human vascular organoids:
The basement membrane (green) around the blood vessels (red) is massively enlarged in diabetic patients (white arrows). This results in impaired blood vessel function and reduced supply of oxygen leading to the severe complications of diabetes such as kidney failure, blindness or amputations. The human vascular organoids that were made “diabetic” in the laboratory recapitulate those basement membrane changes and can now be used as diabetic model in the lab to identify novel therapeutics. (c)IMBA
Vascular Organoid, illustration based on original data. These lab-made blood vessels recapitulate human capillaries. (c)IMP/IMBA Graphics
Vascular organoids for drug testing:
Vascular organoids are produced in a miniature format that allows for high-throughput drug testing on human blood vessels in the lab.