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Diabetic blood vessel changes in patients and human vascular organoids:
The basement membrane (green) around the blood vessels (red) is massively enlarged in diabetic patients (white arrows). This results in impaired blood vessel function and reduced supply of oxygen leading to the severe complications of diabetes such as kidney failure, blindness or amputations. The human vascular organoids that were made “diabetic” in the laboratory recapitulate those basement membrane changes and can now be used as diabetic model in the lab to identify novel therapeutics.
Vascular Organoid, illustration based on original data. These lab-made blood vessels recapitulate human capillaries.
Vascular organoids for drug testing:
Vascular organoids are produced in a miniature format that allows for high-throughput drug testing on human blood vessels in the lab.
Building block of "happiness hormone" is key to controlling immunity in cancer and auto-immune diseases: Tetrahydrobiopterin, or BH4, is needed to produce the “happiness hormone” serotonin or dopamine. Also, it critically controls the growth of T-cells by regulating iron and mitochondrial metabolism. (c)IMP/IMBA Graphics
Building block of "happiness hormone" is key to controlling immunity in cancer and auto-immune diseases: By modulating the pathway which produces BH4 scientists can in essence control T cell responses. (c)IMP/IMBA Graphics
Growing brain cancer in a dish: Neoplastic cerebral organoid with GFP-positive tumor regions (green), which demonstrates glioblastoma-like cellularity. (c)IMBA
Growing brain cancer in a dish: Artistic interpretation of the neoplastic novel brain-cancer or neoplastic organoids which offer a means to investigate, how some of these mutations are driving forces in tumors. (c)BeataScienceArt
EMBO member and HFSP grantee Kikue Tachibana (c)IMBA/Michael Sazel
HFSP Grantee Bonkyoung Too (c)IMBA/Michael Sazel
Not just housekeeping: A new way to control protein production in stem cells.
Image depicts a E4.5 mouse blastocyst showing high levels of protein synthesis (green) and HTATSF1 expression (red). (c)IMBA
Why tumor stem cells stay "forever young": Asymmetric localization of the lncRNA cherub in dividing neuroblasts (neural stem cells). cherub localizes to the basal cell pole.
cherub (red), apical cell marker (white), DNA (cyan). (c)IMBA
ASSCR founding committee: Johann Bauer, Georg Dechant, Frank Edenhofer, Elly Tanaka, Markus Hengstschläger, Dirk Strunk, Peter Valent, Jürgen Knoblich, Katharina Günther (c)IMBA
IMBA Research Report 2016-2017
IMBA Research Report 2015 (5,7 MB; download as pdf)
IMBA Research Report 2014 (4 MB; download as pdf)
IMBA Research Report 2013 (5 MB; download as pdf)
IMBA Research Report 2012 (9 MB; download as pdf)
IMBA Research Report 2011 (9 MB; download as PDF)
IMBA Research Report 2010 (6 MB; download as PDF)
IMBA Research Report 2009 (11MB; download as PDF)
IMBA Research Report 2008 (15MB; download as PDF)
IMBA Research Report 2007 (6,5 MB; download as PDF)
IMBA Research Report 2006 (10 MB; download as PDF)
IMBA Research Report 2005 (3,5 MB; download as PDF)
IMBA Research Report 2004 (6,3 MB; download as PDF)
IMBA Connections No.18
IMBA Connections No.17
IMBA Connections No.16
IMBA Connections No.15
IMBA Connections No.14
IMBA Connections No.13
Jürgen Knoblich, Scientific Director (c)IMBA/Michael Sazel
Josef Penninger, Founding Director (2002 - 2018) (c)IMBA/Michael Sazel
Michael Krebs, Administrative Director (c)IMBA/Michael Sazel