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Thomas Marlovits
Design and function of molecular machines
What keeps cells and organisms alive are specific functions performed by highly organized macromolecular assemblies. Thomas Marlovits' research group wants to understand the architectural design of these ‘biological nanomachines’. The team explores such structures under normal and disease-related conditions. In order to elucidate the molecular mechanisms, the research group uses high-resolution three-dimensional electron microscopy to directly visualize molecular machines in action.
As a joint IMP-IMBA group leader Thomas Marlovits works for both IMBA and the partner institute IMP.
Contact:
Thomas Marlovits
Group Leader
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Selected Publications
| (2011) |
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Schraidt, O., Marlovits, TC. (2011). Three-dimensional model of Salmonella's needle complex at subnanometer resolution.
Science. 331(6021):1192-5
(abstract)
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| (2010) |
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Schraidt, O., Lefebre, MD., Brunner, MJ., Schmied, WH., Schmidt, A., Radics, J., Mechtler, K., Galán, JE., Marlovits, TC. (2010). Topology and organization of the Salmonella typhimurium type III secretion needle complex components.
PLoS Pathog. 6(4):e1000824
(abstract)
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Wagner, S., Königsmaier, L., Lara-Tejero, M., Lefebre, M., Marlovits, TC., Galán, JE. (2010). Organization and coordinated assembly of the type III secretion export apparatus.
Proc Natl Acad Sci U S A. 107(41):17745-50
(abstract)
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| (2006) |
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Marlovits, TC., Kubori, T., Lara-Tejero, M., Thomas, D., Unger, VM., Galán, JE. (2006). Assembly of the inner rod determines needle length in the type III secretion injectisome.
Nature. 441(7093):637-40
(abstract)
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| (2004) |
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Marlovits, TC., Kubori, T., Sukhan, A., Thomas, DR., Galán, JE., Unger, VM. (2004). Structural insights into the assembly of the type III secretion needle complex.
Science. 306(5698):1040-2
(abstract)
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