Sasha Mendjan

Stem Cells and Human Mesodermal Organogenesis

  • Key human organs and tissues including the heart, blood, fat, muscle, and vasculature are derived from the embryonic germ layer called mesoderm. The fascinating journey from early mesodermal precursors to functioning organs is not well understood, and in particular not for human development and disease. Our group is using stem cells to decipher the molecular control of human mesodermal organogenesis and pathogenesis. Based on molecular and developmental insights, our aim is to generate and study functional mesodermal tissues and organ-like structures in a dish.

  • Groupleader at IMBA from October 1, 2015

    Contact:

    Sasha Mendjan
    Group Leader
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Selected Publications

(2015)
 
Bertero, A., Madrigal, P., Galli, A., Hubner, NC., Moreno, I., Burks, D., Brown, S., Pedersen, RA., Gaffney, D., Mendjan, S., Pauklin, S., Vallier, L. (2015). Activin/nodal signaling and NANOG orchestrate human embryonic stem cell fate decisions by controlling the H3K4me3 chromatin mark. Genes Dev. 29(7):702-17 (abstract)
 
(2014)
 
Mendjan, S., Mascetti, VL., Ortmann, D., Ortiz, M., Karjosukarso, DW., Ng, Y., Moreau, T., Pedersen, RA. (2014). NANOG and CDX2 pattern distinct subtypes of human mesoderm during exit from pluripotency. Cell Stem Cell. 15(3):310-25 (abstract)
 
(2012)
 
Pedersen, RA., Mascetti, V., Mendjan, S. (2012). Synthetic organs for regenerative medicine. Cell Stem Cell. 10(6):646-7 (abstract)
 
(2009)
 
Vallier, L., Mendjan, S., Brown, S., Chng, Z., Teo, A., Smithers, LE., Trotter, MW., Cho, CH., Martinez, A., Rugg-Gunn, P., Brons, G., Pedersen, RA. (2009). Activin/Nodal signalling maintains pluripotency by controlling Nanog expression. Development. 136(8):1339-49 (abstract)
 
(2006)
 
Mendjan, S., Taipale, M., Kind, J., Holz, H., Gebhardt, P., Schelder, M., Vermeulen, M., Buscaino, A., Duncan, K., Mueller, J., Wilm, M., Stunnenberg, HG., Saumweber, H., Akhtar, A. (2006). Nuclear pore components are involved in the transcriptional regulation of dosage compensation in Drosophila. Mol Cell. 21(6):811-23 (abstract)
 

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