IMBA - Jürgen Knoblich

Jürgen Knoblich

Senior Scientist

Asymmetric cell division and proliferation control in Drosophila

Stem cells are capable of generating two different kinds of progeny: On one hand, they give rise to differentiating cells, on the other hand, they generate other stem cells which continue to proliferate. How one cell can generate two daughter cells of such different properties and how defects in this asymmetry can contribute to tumor formation, are the questions that the Knoblich Group is trying to resolve.

Selected Publications

Mummery-Widmer, JL., Yamazaki, M., Stoeger, T., Novatchkova, M., Bhalerao, S., Chen, D., Dietzl, G., Dickson, BJ., Knoblich, JA. (2009). Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Nature. 458(7241):987-92 (abstract)

Schwamborn, JC., Berezikov, E., Knoblich, JA. (2009). The TRIM-NHL protein TRIM32 activates microRNAs and prevents self-renewal in mouse neural progenitors. Cell. 136(5):913-25 (abstract)

Knoblich, JA. (2008). Mechanisms of asymmetric stem cell division. Cell. 132(4):583-97 (abstract)

Neumüller, RA., Betschinger, J., Fischer, A., Bushati, N., Poernbacher, I., Mechtler, K., Cohen, SM., Knoblich, JA. (2008). Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage. Nature. 454(7201):241-5 (abstract)

Wirtz-Peitz, F., Nishimura, T., Knoblich, JA. (2008). Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localization. Cell. 135(1):161-73 (abstract)