Content

You are here:

Publications

(2011)
 
Attané, C., Foussal, C., Le Gonidec, S., Benani, A., Daviaud, D., Wanecq, E., Guzmán-Ruiz, R., Dray, C., Bezaire, V., Rancoule, C., Kuba, K., Ruiz-Gayo, M., Levade, T., Penninger, J., Burcelin, R., Pénicaud, L., Valet, P., Castan-Laurell, I. (2011). Apelin Treatment Increases Complete Fatty Acid Oxidation, Mitochondrial Oxidative Capacity, and Biogenesis in Muscle of Insulin-Resistant Mice. Diabetes. (abstract)
 
Bodiga, S., Zhong, JC., Wang, W., Basu, R., Lo, J., Liu, GC., Guo, D., Holland, SM., Scholey, JW., Penninger, JM., Kassiri, Z., Oudit, GY. (2011). Enhanced susceptibility to biomechanical stress in ACE2 null mice is prevented by loss of the p47(phox) NADPH oxidase subunit. Cardiovasc Res. 91(1):151-61 (abstract)
 
Douni, E., Rinotas, V., Makrinou, E., Zwerina, J., Penninger, JM., Eliopoulos, E., Schett, G., Kollias, G. (2011). A RANKL G278R mutation causing osteopetrosis identifies a functional amino acid essential for trimer assembly in RANKL and TNF. Hum Mol Genet. (abstract)
 
Duheron, V., Hess, E., Duval, M., Decossas, M., Castaneda, B., Klöpper, JE., Amoasii, L., Barbaroux, JB., Williams, IR., Yagita, H., Penninger, J., Choi, Y., Lézot, F., Groves, R., Paus, R., Mueller, CG. (2011). Receptor activator of NF-kappaB (RANK) stimulates the proliferation of epithelial cells of the epidermo-pilosebaceous unit. Proc Natl Acad Sci U S A. 108(13):5342-7 (abstract)
 
Elling, U., Taubenschmid, J., Wirnsberger, G., O'Malley, R., Demers, SP., Vanhaelen, Q., Shukalyuk, AI., Schmauss, G., Schramek, D., Schnuetgen, F., von Melchner, H., Ecker, JR., Stanford, WL., Zuber, J., Stark, A., Penninger, JM. (2011). Forward and Reverse Genetics through Derivation of Haploid Mouse Embryonic Stem Cells. Cell Stem Cell. 9(6):563-74 (abstract)
 
Gieger, C., Radhakrishnan, A., Cvejic, A., Tang, W., Porcu, E., Pistis, G., Serbanovic-Canic, J., Elling, U., Goodall, AH., Labrune, Y., Lopez, LM., Mägi, R., Meacham, S., Okada, Y., Pirastu, N., Sorice, R., Teumer, A., Voss, K., Zhang, W., Ramirez-Solis, R., Bis, JC., Ellinghaus, D., Gögele, M., Hottenga, JJ., Langenberg, C., Kovacs, P., O'Reilly, PF., Shin, SY., Esko, T., Hartiala, J., Kanoni, S., Murgia, F., Parsa, A., Stephens, J., van der Harst, P., Ellen van der Schoot, C., Allayee, H., Attwood, A., Balkau, B., Bastardot, F., Basu, S., Baumeister, SE., Biino, G., Bomba, L., Bonnefond, A., Cambien, F., Chambers, JC., Cucca, F., D'Adamo, P., Davies, G., de Boer, RA., de Geus, EJ., Döring, A., Elliott, P., Erdmann, J., Evans, DM., Falchi, M., Feng, W., Folsom, AR., Frazer, IH., Gibson, QD., Glazer, NL., Hammond, C., Hartikainen, AL., Heckbert, SR., Hengstenberg, C., Hersch, M., Illig, T., Loos, RJ., Jolley, J., Tee Khaw, K., Kühnel, B., Kyrtsonis, MC., Lagou, V., Lloyd-Jones, H., Lumley, T., Mangino, M., Maschio, A., Mateo Leach, I., McKnight, B., Memari, Y., Mitchell, BD., Montgomery, GW., Nakamura, Y., Nauck, M., Navis, G., Nöthlings, U., Nolte, IM., Porteous, DJ., Pouta, A., Pramstaller, PP., Pullat, J., Ring, SM., Rotter, JI., Ruggiero, D., Ruokonen, A., Sala, C., Samani, NJ., Sambrook, J., Schlessinger, D., Schreiber, S., Schunkert, H., Scott, J., Smith, NL., Snieder, H., Starr, JM., Stumvoll, M., Takahashi, A., Tang, WH., Taylor, K., Tenesa, A., Lay Thein, S., Tönjes, A., Uda, M., Ulivi, S., van Veldhuisen, DJ., Visscher, PM., Völker, U., Wichmann, HE., Wiggins, KL., Willemsen, G., Yang, TP., Hua Zhao, J., Zitting, P., Bradley, JR., Dedoussis, GV., Gasparini, P., Hazen, SL., Metspalu, A., Pirastu, M., Shuldiner, AR., Joost van Pelt, L., Zwaginga, JJ., Boomsma, DI., Deary, IJ., Franke, A., Froguel, P., Ganesh, SK., Jarvelin, MR., Martin, NG., Meisinger, C., Psaty, BM., Spector, TD., Wareham, NJ., Akkerman, JW., Ciullo, M., Deloukas, P., Greinacher, A., Jupe, S., Kamatani, N., Khadake, J., Kooner, JS., Penninger, J., Prokopenko, I., Stemple, D., Toniolo, D., Wernisch, L., Sanna, S., Hicks, AA., Rendon, A., Ferreira, MA., Ouwehand, WH., Soranzo, N. (2011). New gene functions in megakaryopoiesis and platelet formation. Nature. 480(7376):201-8 (abstract)
 
Hanada, R., Hanada, T., Sigl, V., Schramek, D., Penninger, JM. (2011). RANKL/RANK-beyond bones. J Mol Med (Berl). 89(7):647-56 (abstract)
 
Hanada, R., Penninger, JM. (2011). [Central regulation of body temperature by RANKL/RANK pathway]. Clin Calcium. 21(8):1201-8 (abstract)
 
Jin, R., Song, Z., Yu, S., Piazza, A., Nanda, A., Penninger, JM., Granger, DN., Li, G. (2011). Phosphatidylinositol-3-kinase gamma plays a central role in blood-brain barrier dysfunction in acute experimental stroke. Stroke. 42(7):2033-44 (abstract)
 
Kaminski, S., Hermann-Kleiter, N., Meisel, M., Thuille, N., Cronin, S., Hara, H., Fresser, F., Penninger, JM., Baier, G. (2011). Coronin 1A is an essential regulator of the TGFβ receptor/SMAD3 signaling pathway in Th17 CD4(+) T cells. J Autoimmun. 37(3):198-208 (abstract)
 
Koletar, MM., Cheng, HY., Penninger, JM., Ralph, MR. (2011). Loss of dexras1 alters nonphotic circadian phase shifts and reveals a role for the intergeniculate leaflet (IGL) in gene-targeted mice. Chronobiol Int. 28(7):553-62 (abstract)
 
Kornfeld, JW., Isaacs, A., Vitart, V., Pospisilik, JA., Meitinger, T., Gyllensten, U., Wilson, JF., Rudan, I., Campbell, H., Penninger, JM., Sexl, V., Moriggl, R., van Duijn, C., Pramstaller, PP., Hicks, AA. (2011). Variants in STAT5B associate with serum TC and LDL-C levels. J Clin Endocrinol Metab. 96(9):E1496-501 (abstract)
 
Lee, AW., Mao, Y., Penninger, JM., Yu, S. (2011). Gab2 Promotes Colony-Stimulating Factor 1-Regulated Macrophage Expansion via Alternate Effectors at Different Stages of Development. Mol Cell Biol. 31(22):4563-81 (abstract)
 
Leibbrandt, A., Penninger, JM. (2011). TNF conference 2009: beyond bones - RANKL/RANK in the immune system. Adv Exp Med Biol. 691:5-22 (abstract)
 
Lutz-Nicoladoni, C., Wallner, S., Stoitzner, P., Pircher, M., Gruber, T., Wolf, AM., Gastl, G., Penninger, JM., Baier, G., Wolf, D. (2011). Reinforcement of cancer immunotherapy by adoptive transfer of cblb-deficient CD8(+) T cells combined with a DC vaccine. Immunol Cell Biol. (abstract)
 
Meng, X., Arocena, M., Penninger, J., Gage, FH., Zhao, M., Song, B. (2011). PI3K mediated electrotaxis of embryonic and adult neural progenitor cells in the presence of growth factors. Exp Neurol. 227(1):210-7 (abstract)
 
Miyamoto, K., Yoshida, S., Kawasumi, M., Hashimoto, K., Kimura, T., Sato, Y., Kobayashi, T., Miyauchi, Y., Hoshi, H., Iwasaki, R., Miyamoto, H., Hao, W., Morioka, H., Chiba, K., Kobayashi, T., Yasuda, H., Penninger, JM., Toyama, Y., Suda, T., Miyamoto, T. (2011). Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization. J Exp Med. 208(11):2175-81 (abstract)
 
Mouri, Y., Yano, M., Shinzawa, M., Shimo, Y., Hirota, F., Nishikawa, Y., Nii, T., Kiyonari, H., Abe, T., Uehara, H., Izumi, K., Tamada, K., Chen, L., Penninger, JM., Inoue, J., Akiyama, T., Matsumoto, M. (2011). Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma. J Immunol. 186(9):5047-57 (abstract)
 
Muto, A., Mizoguchi, T., Udagawa, N., Ito, S., Kawahara, I., Abiko, Y., Arai, A., Harada, S., Kobayashi, Y., Nakamichi, Y., Penninger, JM., Noguchi, T., Takahashi, N. (2011). Lineage-committed osteoclast precursors circulate in blood and settle down into bone. J Bone Miner Res. 26(12):2978-90 (abstract)
 
Nakashima, T., Hayashi, M., Fukunaga, T., Kurata, K., Oh-Hora, M., Feng, JQ., Bonewald, LF., Kodama, T., Wutz, A., Wagner, EF., Penninger, JM., Takayanagi, H. (2011). Evidence for osteocyte regulation of bone homeostasis through RANKL expression. Nat Med. 17(10):1231-4 (abstract)
 
Neely, GG., Keene, AC., Duchek, P., Chang, EC., Wang, QP., Aksoy, YA., Rosenzweig, M., Costigan, M., Woolf, CJ., Garrity, PA., Penninger, JM. (2011). TrpA1 regulates thermal nociception in Drosophila. PLoS One. 6(8):e24343 (abstract)
 
Oh, SY., Park, JU., Zheng, T., Kim, YK., Wu, F., Cho, SH., Barber, D., Penninger, J., Zhu, Z. (2011). Cbl-b regulates airway mucosal tolerance to aeroallergen. Clin Exp Allergy. 41(3):434-42 (abstract)
 
Oudit, GY., Penninger, JM. (2011). Recombinant human angiotensin-converting enzyme 2 as a new renin-angiotensin system peptidase for heart failure therapy. Curr Heart Fail Rep. 8(3):176-83 (abstract)
 
Paolino, M., Thien, CB., Gruber, T., Hinterleitner, R., Baier, G., Langdon, WY., Penninger, JM. (2011). Essential role of E3 ubiquitin ligase activity in Cbl-b-regulated T cell functions. J Immunol. 186(4):2138-47 (abstract)
 
Schramek, D., Kotsinas, A., Meixner, A., Wada, T., Elling, U., Pospisilik, JA., Neely, GG., Zwick, RH., Sigl, V., Forni, G., Serrano, M., Gorgoulis, VG., Penninger, JM. (2011). The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression. Nat Genet. 43(3):212-9 (abstract)
 
Schramek, D., Sigl, V., Penninger, JM. (2011). RANKL and RANK in sex hormone-induced breast cancer and breast cancer metastasis. Trends Endocrinol Metab. 22(5):188-94 (abstract)
 
Taschler, U., Radner, FP., Heier, C., Schreiber, R., Schweiger, M., Schoiswohl, G., Preiss-Landl, K., Jaeger, D., Reiter, B., Koefeler, HC., Wojciechowski, J., Theussl, C., Penninger, JM., Lass, A., Haemmerle, G., Zechner, R., Zimmermann, R. (2011). Monoglyceride lipase deficiency in mice impairs lipolysis and attenuates diet-induced insulin resistance. J Biol Chem. 286(20):17467-77 (abstract)
 
Yamasaki, T., Kawasaki, H., Arakawa, S., Shimizu, K., Shimizu, S., Reiner, O., Okano, H., Nishina, S., Azuma, N., Penninger, JM., Katada, T., Nishina, H. (2011). Stress-activated protein kinase MKK7 regulates axon elongation in the developing cerebral cortex. J Neurosci. 31(46):16872-83 (abstract)
 
Zhong, JC., Ye, JY., Jin, HY., Yu, X., Yu, HM., Zhu, DL., Gao, PJ., Huang, DY., Shuster, M., Loibner, H., Guo, JM., Yu, XY., Xiao, BX., Gong, ZH., Penninger, JM., Oudit, GY. (2011). Telmisartan attenuates aortic hypertrophy in hypertensive rats by the modulation of ACE2 and profilin-1 expression. Regul Pept. 166(1-3):90-7 (abstract)
 
Zhong, J., Guo, D., Chen, CB., Wang, W., Schuster, M., Loibner, H., Penninger, JM., Scholey, JW., Kassiri, Z., Oudit, GY. (2011). Prevention of angiotensin II-mediated renal oxidative stress, inflammation, and fibrosis by angiotensin-converting enzyme 2. Hypertension. 57(2):314-22 (abstract)
 
(2010)
 
Awad, AE., Kandalam, V., Chakrabarti, S., Wang, X., Penninger, JM., Davidge, ST., Oudit, GY., Kassiri, Z. (2010). Tumor necrosis factor induces matrix metalloproteinases in cardiomyocytes and cardiofibroblasts differentially via superoxide production in a PI3Kgamma-dependent manner. Am J Physiol Cell Physiol. 298(3):C679-92 (abstract)
 
Blaas, L., Kornfeld, JW., Schramek, D., Musteanu, M., Zollner, G., Gumhold, J., van Zijl, F., Schneller, D., Esterbauer, H., Egger, G., Mair, M., Kenner, L., Mikulits, W., Eferl, R., Moriggl, R., Penninger, J., Trauner, M., Casanova, E. (2010). Disruption of the growth hormone--signal transducer and activator of transcription 5--insulinlike growth factor 1 axis severely aggravates liver fibrosis in a mouse model of cholestasis. Hepatology. 51(4):1319-26 (abstract)
 
Charlier, E., Condé, C., Zhang, J., Deneubourg, L., Di Valentin, E., Rahmouni, S., Chariot, A., Agostinis, P., Pang, PC., Haslam, SM., Dell, A., Penninger, J., Erneux, C., Piette, J., Gloire, G. (2010). SHIP-1 inhibits CD95/APO-1/Fas-induced apoptosis in primary T lymphocytes and T leukemic cells by promoting CD95 glycosylation independently of its phosphatase activity. Leukemia. 24(4):821-32 (abstract)
 
del Toro, R., Prahst, C., Mathivet, T., Siegfried, G., Kaminker, JS., Larrivee, B., Breant, C., Duarte, A., Takakura, N., Fukamizu, A., Penninger, J., Eichmann, A. (2010). Identification and functional analysis of endothelial tip cell-enriched genes. Blood. 116(19):4025-33 (abstract)
 
Fleuren, ED., O'Toole, S., Millar, EK., McNeil, C., Lopez-Knowles, E., Boulghourjian, A., Croucher, DR., Schramek, D., Brummer, T., Penninger, JM., Sutherland, RL., Daly, RJ. (2010). Overexpression of the oncogenic signal transducer Gab2 occurs early in breast cancer development. Int J Cancer. 127(6):1486-92 (abstract)
 
Guo, D., Kassiri, Z., Basu, R., Chow, FL., Kandalam, V., Damilano, F., Liang, W., Izumo, S., Hirsch, E., Penninger, JM., Backx, PH., Oudit, GY. (2010). Loss of PI3Kγ enhances cAMP-dependent MMP remodeling of the myocardial N-cadherin adhesion complexes and extracellular matrix in response to early biomechanical stress. Circ Res. 107(10):1275-89 (abstract)
 
Hanada, R., Hanada, T., Penninger, JM. (2010). Physiology and pathophysiology of the RANKL/RANK system. Biol Chem. 391(12):1365-70 (abstract)
 
Haubner, BJ., Neely, GG., Voelkl, JG., Damilano, F., Kuba, K., Imai, Y., Komnenovic, V., Mayr, A., Pachinger, O., Hirsch, E., Penninger, JM., Metzler, B. (2010). PI3Kgamma protects from myocardial ischemia and reperfusion injury through a kinase-independent pathway. PLoS One. 5(2):e9350 (abstract)
 
Heindl-Erdmann, C., Axmann, R., Kreitz, S., Zwerina, J., Penninger, J., Schett, G., Brune, K., Hess, A. (2010). Combining functional magnetic resonance imaging with mouse genomics: new options in pain research. Neuroreport. 21(1):29-33 (abstract)
 
Imai, Y., Kuba, K., Ohto-Nakanishi, T., Penninger, JM. (2010). Angiotensin-converting enzyme 2 (ACE2) in disease pathogenesis. Circ J. 74(3):405-10 (abstract)
 
Jin, R., Yu, S., Song, Z., Quillin, JW., Deasis, DP., Penninger, JM., Nanda, A., Granger, DN., Li, G. (2010). Phosphoinositide 3-kinase-gamma expression is upregulated in brain microglia and contributes to ischemia-induced microglial activation in acute experimental stroke. Biochem Biophys Res Commun. 399(3):458-64 (abstract)
 
Klaiber, M., Kruse, M., Völker, K., Schröter, J., Feil, R., Freichel, M., Gerling, A., Feil, S., Dietrich, A., Londoño, JE., Baba, HA., Abramowitz, J., Birnbaumer, L., Penninger, JM., Pongs, O., Kuhn, M. (2010). Novel insights into the mechanisms mediating the local antihypertrophic effects of cardiac atrial natriuretic peptide: role of cGMP-dependent protein kinase and RGS2. Basic Res Cardiol. 105(5):583-95 (abstract)
 
Kuba, K., Imai, Y., Ohto-Nakanishi, T., Penninger, JM. (2010). Trilogy of ACE2: a peptidase in the renin-angiotensin system, a SARS receptor, and a partner for amino acid transporters. Pharmacol Ther. 128(1):119-28 (abstract)
 
Leibbrandt, A., Penninger, JM. (2010). Novel functions of RANK(L) signaling in the immune system. Adv Exp Med Biol. 658:77-94 (abstract)
 
Meixner, A., Karreth, F., Kenner, L., Penninger, JM., Wagner, EF. (2010). Jun and JunD-dependent functions in cell proliferation and stress response. Cell Death Differ. 17(9):1409-19 (abstract)
 
Molyneux, SD., Di Grappa, MA., Beristain, AG., McKee, TD., Wai, DH., Paderova, J., Kashyap, M., Hu, P., Maiuri, T., Narala, SR., Stambolic, V., Squire, J., Penninger, J., Sanchez, O., Triche, TJ., Wood, GA., Kirschner, LS., Khokha, R. (2010). Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice. J Clin Invest. 120(9):3310-25 (abstract)
 
Neely, GG., Hess, A., Costigan, M., Keene, AC., Goulas, S., Langeslag, M., Griffin, RS., Belfer, I., Dai, F., Smith, SB., Diatchenko, L., Gupta, V., Xia, CP., Amann, S., Kreitz, S., Heindl-Erdmann, C., Wolz, S., Ly, CV., Arora, S., Sarangi, R., Dan, D., Novatchkova, M., Rosenzweig, M., Gibson, DG., Truong, D., Schramek, D., Zoranovic, T., Cronin, SJ., Angjeli, B., Brune, K., Dietzl, G., Maixner, W., Meixner, A., Thomas, W., Pospisilik, JA., Alenius, M., Kress, M., Subramaniam, S., Garrity, PA., Bellen, HJ., Woolf, CJ., Penninger, JM. (2010). A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. Cell. 143(4):628-38 (abstract)
 
Neely, GG., Kuba, K., Cammarato, A., Isobe, K., Amann, S., Zhang, L., Murata, M., Elmén, L., Gupta, V., Arora, S., Sarangi, R., Dan, D., Fujisawa, S., Usami, T., Xia, CP., Keene, AC., Alayari, NN., Yamakawa, H., Elling, U., Berger, C., Novatchkova, M., Koglgruber, R., Fukuda, K., Nishina, H., Isobe, M., Pospisilik, JA., Imai, Y., Pfeufer, A., Hicks, AA., Pramstaller, PP., Subramaniam, S., Kimura, A., Ocorr, K., Bodmer, R., Penninger, JM. (2010). A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Cell. 141(1):142-53 (abstract)
 
Oudit, GY., Liu, GC., Zhong, J., Basu, R., Chow, FL., Zhou, J., Loibner, H., Janzek, E., Schuster, M., Penninger, JM., Herzenberg, AM., Kassiri, Z., Scholey, JW. (2010). Human recombinant ACE2 reduces the progression of diabetic nephropathy. Diabetes. 59(2):529-38 (abstract)
 
Paolino, M., Penninger, JM. (2010). Cbl-b in T-cell activation. Semin Immunopathol. 32(2):137-48 (abstract)
 
Pospisilik, JA., Schramek, D., Schnidar, H., Cronin, SJ., Nehme, NT., Zhang, X., Knauf, C., Cani, PD., Aumayr, K., Todoric, J., Bayer, M., Haschemi, A., Puviindran, V., Tar, K., Orthofer, M., Neely, GG., Dietzl, G., Manoukian, A., Funovics, M., Prager, G., Wagner, O., Ferrandon, D., Aberger, F., Hui, CC., Esterbauer, H., Penninger, JM. (2010). Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. Cell. 140(1):148-60 (abstract)
 
Saade, M., Irla, M., Yammine, M., Boulanger, N., Victorero, G., Vincentelli, R., Penninger, JM., Holländer, GA., Chauvet, S., Nguyen, C. (2010). Spatial (Tbata) expression in mature medullary thymic epithelial cells. Eur J Immunol. 40(2):530-8 (abstract)
 
Schramek, D., Leibbrandt, A., Sigl, V., Kenner, L., Pospisilik, JA., Lee, HJ., Hanada, R., Joshi, PA., Aliprantis, A., Glimcher, L., Pasparakis, M., Khokha, R., Ormandy, CJ., Widschwendter, M., Schett, G., Penninger, JM. (2010). Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer. Nature. 468(7320):98-102 (abstract)
 
Seo, J., Asaoka, Y., Nagai, Y., Hirayama, J., Yamasaki, T., Namae, M., Ohata, S., Shimizu, N., Negishi, T., Kitagawa, D., Kondoh, H., Furutani-Seiki, M., Penninger, JM., Katada, T., Nishina, H. (2010). Negative regulation of wnt11 expression by Jnk signaling during zebrafish gastrulation. J Cell Biochem. 110(4):1022-37 (abstract)
 
Treml, B., Neu, N., Kleinsasser, A., Gritsch, C., Finsterwalder, T., Geiger, R., Schuster, M., Janzek, E., Loibner, H., Penninger, J., Loeckinger, A. (2010). Recombinant angiotensin-converting enzyme 2 improves pulmonary blood flow and oxygenation in lipopolysaccharide-induced lung injury in piglets. Crit Care Med. 38(2):596-601 (abstract)
 
Wysocki, J., Ye, M., Rodriguez, E., González-Pacheco, FR., Barrios, C., Evora, K., Schuster, M., Loibner, H., Brosnihan, KB., Ferrario, CM., Penninger, JM., Batlle, D. (2010). Targeting the degradation of angiotensin II with recombinant angiotensin-converting enzyme 2: prevention of angiotensin II-dependent hypertension. Hypertension. 55(1):90-8 (abstract)
 
Xu, H., Su, Z., Wu, J., Yang, M., Penninger, JM., Martin, CM., Kvietys, PR., Rui, T. (2010). The alarmin cytokine, high mobility group box 1, is produced by viable cardiomyocytes and mediates the lipopolysaccharide-induced myocardial dysfunction via a TLR4/phosphatidylinositol 3-kinase gamma pathway. J Immunol. 184(3):1492-8 (abstract)
 
Zhong, J., Basu, R., Guo, D., Chow, FL., Byrns, S., Schuster, M., Loibner, H., Wang, XH., Penninger, JM., Kassiri, Z., Oudit, GY. (2010). Angiotensin-converting enzyme 2 suppresses pathological hypertrophy, myocardial fibrosis, and cardiac dysfunction. Circulation. 122(7):717-28, 18 p following 728 (abstract)
 
(2009)
 
Blyszczuk, P., Kania, G., Dieterle, T., Marty, RR., Valaperti, A., Berthonneche, C., Pedrazzini, T., Berger, CT., Dirnhofer, S., Matter, CM., Penninger, JM., Lüscher, TF., Eriksson, U. (2009). Myeloid differentiation factor-88/interleukin-1 signaling controls cardiac fibrosis and heart failure progression in inflammatory dilated cardiomyopathy. Circ Res. 105(9):912-20 (abstract)
 
Camargo, SM., Singer, D., Makrides, V., Huggel, K., Pos, KM., Wagner, CA., Kuba, K., Danilczyk, U., Skovby, F., Kleta, R., Penninger, JM., Verrey, F. (2009). Tissue-specific amino acid transporter partners ACE2 and collectrin differentially interact with hartnup mutations. Gastroenterology. 136(3):872-82 (abstract)
 
Cronin, SJ., Nehme, NT., Limmer, S., Liegeois, S., Pospisilik, JA., Schramek, D., Leibbrandt, A., Simoes, Rde M., Gruber, S., Puc, U., Ebersberger, I., Zoranovic, T., Neely, GG., von Haeseler, A., Ferrandon, D., Penninger, JM. (2009). Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection. Science. 325(5938):340-3 (abstract)
 
Fontán-Lozano, A., Romero-Granados, R., del-Pozo-Martín, Y., Suárez-Pereira, I., Delgado-García, JM., Penninger, JM., Carrión, AM. (2009). Lack of DREAM protein enhances learning and memory and slows brain aging. Curr Biol. 19(1):54-60 (abstract)
 
Galluzzi, L., Aaronson, SA., Abrams, J., Alnemri, ES., Andrews, DW., Baehrecke, EH., Bazan, NG., Blagosklonny, MV., Blomgren, K., Borner, C., Bredesen, DE., Brenner, C., Castedo, M., Cidlowski, JA., Ciechanover, A., Cohen, GM., De Laurenzi, V., De Maria, R., Deshmukh, M., Dynlacht, BD., El-Deiry, WS., Flavell, RA., Fulda, S., Garrido, C., Golstein, P., Gougeon, ML., Green, DR., Gronemeyer, H., Hajnóczky, G., Hardwick, JM., Hengartner, MO., Ichijo, H., Jäättelä, M., Kepp, O., Kimchi, A., Klionsky, DJ., Knight, RA., Kornbluth, S., Kumar, S., Levine, B., Lipton, SA., Lugli, E., Madeo, F., Malomi, W., Marine, JC., Martin, SJ., Medema, JP., Mehlen, P., Melino, G., Moll, UM., Morselli, E., Nagata, S., Nicholson, DW., Nicotera, P., Nuñez, G., Oren, M., Penninger, J., Pervaiz, S., Peter, ME., Piacentini, M., Prehn, JH., Puthalakath, H., Rabinovich, GA., Rizzuto, R., Rodrigues, CM., Rubinsztein, DC., Rudel, T., Scorrano, L., Simon, HU., Steller, H., Tschopp, J., Tsujimoto, Y., Vandenabeele, P., Vitale, I., Vousden, KH., Youle, RJ., Yuan, J., Zhivotovsky, B., Kroemer, G. (2009). Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ. 16(8):1093-107 (abstract)
 
Gruber, T., Hermann-Kleiter, N., Hinterleitner, R., Fresser, F., Schneider, R., Gastl, G., Penninger, JM., Baier, G. (2009). PKC-theta modulates the strength of T cell responses by targeting Cbl-b for ubiquitination and degradation. Sci Signal. 2(76):ra30 (abstract)
 
Hanada, R., Leibbrandt, A., Hanada, T., Kitaoka, S., Furuyashiki, T., Fujihara, H., Trichereau, J., Paolino, M., Qadri, F., Plehm, R., Klaere, S., Komnenovic, V., Mimata, H., Yoshimatsu, H., Takahashi, N., von Haeseler, A., Bader, M., Kilic, SS., Ueta, Y., Pifl, C., Narumiya, S., Penninger, JM. (2009). Central control of fever and female body temperature by RANKL/RANK. Nature. 462(7272):505-9 (abstract)
 
Hayer, S., Pundt, N., Peters, MA., Wunrau, C., Kühnel, I., Neugebauer, K., Strietholt, S., Zwerina, J., Korb, A., Penninger, J., Joosten, LA., Gay, S., Rückle, T., Schett, G., Pap, T. (2009). PI3Kgamma regulates cartilage damage in chronic inflammatory arthritis. FASEB J. 23(12):4288-98 (abstract)
 
Joza, N., Pospisilik, JA., Hangen, E., Hanada, T., Modjtahedi, N., Penninger, JM., Kroemer, G. (2009). AIF: not just an apoptosis-inducing factor. Ann N Y Acad Sci. 1171:2-11 (abstract)
 
Kassiri, Z., Zhong, J., Guo, D., Basu, R., Wang, X., Liu, PP., Scholey, JW., Penninger, JM., Oudit, GY. (2009). Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction. Circ Heart Fail. 2(5):446-55 (abstract)
 
Köcher, T., Pichler, P., Schutzbier, M., Stingl, C., Kaul, A., Teucher, N., Hasenfuss, G., Penninger, JM., Mechtler, K. (2009). High precision quantitative proteomics using iTRAQ on an LTQ Orbitrap: a new mass spectrometric method combining the benefits of all. J Proteome Res. 8(10):4743-52 (abstract)
 
Leibbrandt, A., Penninger, JM. (2009). RANK(L) as a key target for controlling bone loss. Adv Exp Med Biol. 647:130-45 (abstract)
 
Leibbrandt, A., Penninger, JM. (2009). ESCI award lecture: from a little mouse to rationale medicine for bone loss. Eur J Clin Invest. 39(10):842-50 (abstract)
 
Leibbrandt, A., Penninger, JM. (2009). RANKL/RANK as key factors for osteoclast development and bone loss in arthropathies. Adv Exp Med Biol. 649:100-13 (abstract)
 
Loeser, S., Penninger, J.M. (2009). Regulation of T cell anergy and escape from regulatory T cells suppression by Cbl-b. In: The Epigenetics of Autoimmune disease. Ed. N. Zouali. :pp. 75-94
 
Mizoguchi, T., Muto, A., Udagawa, N., Arai, A., Yamashita, T., Hosoya, A., Ninomiya, T., Nakamura, H., Yamamoto, Y., Kinugawa, S., Nakamura, M., Nakamichi, Y., Kobayashi, Y., Nagasawa, S., Oda, K., Tanaka, H., Tagaya, M., Penninger, JM., Ito, M., Takahashi, N. (2009). Identification of cell cycle-arrested quiescent osteoclast precursors in vivo. J Cell Biol. 184(4):541-54 (abstract)
 
Nagatake, T., Fukuyama, S., Kim, DY., Goda, K., Igarashi, O., Sato, S., Nochi, T., Sagara, H., Yokota, Y., Jetten, AM., Kaisho, T., Akira, S., Mimuro, H., Sasakawa, C., Fukui, Y., Fujihashi, K., Akiyama, T., Inoue, J., Penninger, JM., Kunisawa, J., Kiyono, H. (2009). Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity. J Exp Med. 206(11):2351-64 (abstract)
 
Osterreicher, CH., Taura, K., De Minicis, S., Seki, E., Penz-Osterreicher, M., Kodama, Y., Kluwe, J., Schuster, M., Oudit, GY., Penninger, JM., Brenner, DA. (2009). Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice. Hepatology. 50(3):929-38 (abstract)
 
Oudit, GY., Imai, Y., Kuba, K., Scholey, JW., Penninger, JM. (2009). The role of ACE2 in pulmonary diseases--relevance for the nephrologist. Nephrol Dial Transplant. 24(5):1362-5 (abstract)
 
Oudit, GY., Kassiri, Z., Jiang, C., Liu, PP., Poutanen, SM., Penninger, JM., Butany, J. (2009). SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS. Eur J Clin Invest. 39(7):618-25 (abstract)
 
Oudit, GY., Penninger, JM. (2009). Cardiac regulation by phosphoinositide 3-kinases and PTEN. Cardiovasc Res. 82(2):250-60 (abstract)
 
Paolino, M., Penninger, JM. (2009). E3 ubiquitin ligases in T-cell tolerance. Eur J Immunol. 39(9):2337-44 (abstract)
 
Singer, D., Camargo, SM., Huggel, K., Romeo, E., Danilczyk, U., Kuba, K., Chesnov, S., Caron, MG., Penninger, JM., Verrey, F. (2009). Orphan transporter SLC6A18 is renal neutral amino acid transporter B0AT3. J Biol Chem. 284(30):19953-60 (abstract)
 
Spurrell, DR., Luckashenak, NA., Minney, DC., Chaplin, A., Penninger, JM., Liwski, RS., Clements, JL., West, KA. (2009). Vav1 regulates the migration and adhesion of dendritic cells. J Immunol. 183(1):310-8 (abstract)
 
Tanemura, S., Momose, H., Shimizu, N., Kitagawa, D., Seo, J., Yamasaki, T., Nakagawa, K., Kajiho, H., Penninger, JM., Katada, T., Nishina, H. (2009). Blockage by SP600125 of Fcepsilon receptor-induced degranulation and cytokine gene expression in mast cells is mediated through inhibition of phosphatidylinositol 3-kinase signalling pathway. J Biochem. 145(3):345-54 (abstract)
 
(2008)
 
Akiyama, T., Shimo, Y., Yanai, H., Qin, J., Ohshima, D., Maruyama, Y., Asaumi, Y., Kitazawa, J., Takayanagi, H., Penninger, JM., Matsumoto, M., Nitta, T., Takahama, Y., Inoue, J. (2008). The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. Immunity. 29(3):423-37 (abstract)
 
Ban, K., Cooper, AJ., Samuel, S., Bhatti, A., Patel, M., Izumo, S., Penninger, JM., Backx, PH., Oudit, GY., Tsushima, RG. (2008). Phosphatidylinositol 3-kinase gamma is a critical mediator of myocardial ischemic and adenosine-mediated preconditioning. Circ Res. 103(6):643-53 (abstract)
 
Chavakis, E., Carmona, G., Urbich, C., Göttig, S., Henschler, R., Penninger, JM., Zeiher, AM., Chavakis, T., Dimmeler, S. (2008). Phosphatidylinositol-3-kinase-gamma is integral to homing functions of progenitor cells. Circ Res. 102(8):942-9 (abstract)
 
Galluzzi, L., Joza, N., Tasdemir, E., Maiuri, MC., Hengartner, M., Abrams, JM., Tavernarakis, N., Penninger, J., Madeo, F., Kroemer, G. (2008). No death without life: vital functions of apoptotic effectors. Cell Death Differ. 15(7):1113-23 (abstract)
 
Garabelli, PJ., Modrall, JG., Penninger, JM., Ferrario, CM., Chappell, MC. (2008). Distinct roles for angiotensin-converting enzyme 2 and carboxypeptidase A in the processing of angiotensins within the murine heart. Exp Physiol. 93(5):613-21 (abstract)
 
Hara, H., Ishihara, C., Takeuchi, A., Xue, L., Morris, SW., Penninger, JM., Yoshida, H., Saito, T. (2008). Cell type-specific regulation of ITAM-mediated NF-kappaB activation by the adaptors, CARMA1 and CARD9. J Immunol. 181(2):918-30 (abstract)
 
Haubner, B. J., Neely, G., Pachinger, O., Penninger, J. M., Metzler, B. (2008). PI3Kgamma AKTing during myocardial ischemia and reperfusion. Wiener Klin. Wochenschrift. (15):95-97
 
Hikosaka, Y., Nitta, T., Ohigashi, I., Yano, K., Ishimaru, N., Hayashi, Y., Matsumoto, M., Matsuo, K., Penninger, JM., Takayanagi, H., Yokota, Y., Yamada, H., Yoshikai, Y., Inoue, J., Akiyama, T., Takahama, Y. (2008). The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator. Immunity. 29(3):438-50 (abstract)
 
Imai, Y., Kuba, K., Neely, GG., Yaghubian-Malhami, R., Perkmann, T., van Loo, G., Ermolaeva, M., Veldhuizen, R., Leung, YH., Wang, H., Liu, H., Sun, Y., Pasparakis, M., Kopf, M., Mech, C., Bavari, S., Peiris, JS., Slutsky, AS., Akira, S., Hultqvist, M., Holmdahl, R., Nicholls, J., Jiang, C., Binder, CJ., Penninger, JM. (2008). Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell. 133(2):235-49 (abstract)
 
Imai, Y., Kuba, K., Penninger, JM. (2008). [Lessons from SARS: a new potential therapy for acute respiratory distress syndrome (ARDS) with angiotensin converting enzyme 2 (ACE2)]. Masui. 57(3):302-10 (abstract)
 
Imai, Y., Kuba, K., Penninger, JM. (2008). The discovery of angiotensin-converting enzyme 2 and its role in acute lung injury in mice. Exp Physiol. 93(5):543-8 (abstract)
 
Joza, N., Galindo, K., Pospisilik, JA., Benit, P., Rangachari, M., Kanitz, EE., Nakashima, Y., Neely, GG., Rustin, P., Abrams, JM., Kroemer, G., Penninger, JM. (2008). The molecular archaeology of a mitochondrial death effector: AIF in Drosophila. Cell Death Differ. 15(6):1009-18 (abstract)
 
Kuwana, H., Terada, Y., Kobayashi, T., Okado, T., Penninger, JM., Irie-Sasaki, J., Sasaki, T., Sasaki, S. (2008). The phosphoinositide-3 kinase gamma-Akt pathway mediates renal tubular injury in cisplatin nephrotoxicity. Kidney Int. 73(4):430-45 (abstract)
 
Leibbrandt, A., Penninger, J. M. (2008). The role of RANKL in cancer. In: Encyclopedia of Cancer. Ed. Schwab, M. Springer.
 
Leibbrandt, A., Penninger, J. M. (2008). RANK(L) as a key target for controlling bone loss. In: Therapeutic Targets of the TNF Superfamily. Ed. I. Grewal. Landes Bioscience/Eurekah.com.
 
Leibbrandt, A., Penninger, JM. (2008). RANK/RANKL: regulators of immune responses and bone physiology. Ann N Y Acad Sci. 1143:123-50 (abstract)
 
Loeser, S., Penninger, J.M. (2008). The Role of the E3 ubiquitin ligase Cbl-b in T-cells signalling and tolerance. In: CBL Proteins. Ed. A. Tsygankov. Nova Science Publishers Inc. :Chapter 9
 
Lovren, F., Pan, Y., Quan, A., Teoh, H., Wang, G., Shukla, PC., Levitt, KS., Oudit, GY., Al-Omran, M., Stewart, DJ., Slutsky, AS., Peterson, MD., Backx, PH., Penninger, JM., Verma, S. (2008). Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis. Am J Physiol Heart Circ Physiol. 295(4):H1377-84 (abstract)
 
Meixner, A., Zenz, R., Schonthaler, HB., Kenner, L., Scheuch, H., Penninger, JM., Wagner, EF. (2008). Epidermal JunB represses G-CSF transcription and affects haematopoiesis and bone formation. Nat Cell Biol. 10(8):1003-11 (abstract)
 
Oudit, GY., Kassiri, Z., Zhou, J., Liu, QC., Liu, PP., Backx, PH., Dawood, F., Crackower, MA., Scholey, JW., Penninger, JM. (2008). Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress. Cardiovasc Res. 78(3):505-14 (abstract)
 
Penninger, J., Imai, Y., Kuba, K. (2008). The discovery of ACE2 and its role in acute lung injury. Exp Physiol. (abstract)
 
Penninger, J.M. (2008). Do genes dream? In: Identitaet(en). Ed. GLOBArt. Springer.
 
Qiao, G., Li, Z., Molinero, L., Alegre, ML., Ying, H., Sun, Z., Penninger, JM., Zhang, J. (2008). T-cell receptor-induced NF-kappaB activation is negatively regulated by E3 ubiquitin ligase Cbl-b. Mol Cell Biol. 28(7):2470-80 (abstract)
 
Raberger, J., Boucheron, N., Sakaguchi, S., Penninger, JM., Ellmeier, W. (2008). Impaired T-cell development in the absence of Vav1 and Itk. Eur J Immunol. 38(12):3530-42 (abstract)
 
Reich, HN., Oudit, GY., Penninger, JM., Scholey, JW., Herzenberg, AM. (2008). Decreased glomerular and tubular expression of ACE2 in patients with type 2 diabetes and kidney disease. Kidney Int. 74(12):1610-6 (abstract)
 
Wada, T., Stepniak, E., Hui, L., Leibbrandt, A., Katada, T., Nishina, H., Wagner, EF., Penninger, JM. (2008). Antagonistic control of cell fates by JNK and p38-MAPK signaling. Cell Death Differ. 15(1):89-93 (abstract)
 
(2007)
 
Alnaeeli, M., Park, J., Mahamed, D., Penninger, JM., Teng, YT. (2007). Dendritic cells at the osteo-immune interface: implications for inflammation-induced bone loss. J Bone Miner Res. 22(6):775-80 (abstract)
 
Cronin, SJ., Penninger, JM. (2007). From T-cell activation signals to signaling control of anti-cancer immunity. Immunol Rev. 220:151-68 (abstract)
 
Feraud, O., Debili, N., Penninger, JM., Kroemer, G. (2007). Cavitation of embryoid bodies requires optimal oxidative phosphorylation and AIF. Cell Death Differ. 14(2):385-7 (abstract)
 
Fischer, L., Gukovskaya, AS., Penninger, JM., Mareninova, OA., Friess, H., Gukovsky, I., Pandol, SJ. (2007). Phosphatidylinositol 3-kinase facilitates bile acid-induced Ca(2+) responses in pancreatic acinar cells. Am J Physiol Gastrointest Liver Physiol. 292(3):G875-86 (abstract)
 
Hara, H., Ishihara, C., Takeuchi, A., Imanishi, T., Xue, L., Morris, SW., Inui, M., Takai, T., Shibuya, A., Saijo, S., Iwakura, Y., Ohno, N., Koseki, H., Yoshida, H., Penninger, JM., Saito, T. (2007). The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors. Nat Immunol. 8(6):619-29 (abstract)
 
Imai, Y., Kuba, K., Penninger, JM. (2007). Angiotensin-converting enzyme 2 in acute respiratory distress syndrome. Cell Mol Life Sci. 64(15):2006-12 (abstract)
 
Kuba, K., Zhang, L., Imai, Y., Arab, S., Chen, M., Maekawa, Y., Leschnik, M., Leibbrandt, A., Markovic, M., Makovic, M., Schwaighofer, J., Beetz, N., Musialek, R., Neely, GG., Komnenovic, V., Kolm, U., Metzler, B., Ricci, R., Hara, H., Meixner, A., Nghiem, M., Chen, X., Dawood, F., Wong, KM., Sarao, R., Cukerman, E., Kimura, A., Hein, L., Thalhammer, J., Liu, PP., Penninger, JM. (2007). Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload. Circ Res. 101(4):e32-42 (abstract)
 
Liu, L., Puri, KD., Penninger, JM., Kubes, P. (2007). Leukocyte PI3Kgamma and PI3Kdelta have temporally distinct roles for leukocyte recruitment in vivo. Blood. 110(4):1191-8 (abstract)
 
Loeser, S., Loser, K., Bijker, MS., Rangachari, M., van der Burg, SH., Wada, T., Beissert, S., Melief, CJ., Penninger, JM. (2007). Spontaneous tumor rejection by cbl-b-deficient CD8+ T cells. J Exp Med. 204(4):879-91 (abstract)
 
Loeser, S., Penninger, JM. (2007). Regulation of peripheral T cell tolerance by the E3 ubiquitin ligase Cbl-b. Semin Immunol. 19(3):206-14 (abstract)
 
Loeser, S., Penninger, JM. (2007). The ubiquitin E3 ligase Cbl-b in T cells tolerance and tumor immunity. Cell Cycle. 6(20):2478-85 (abstract)
 
Nakamichi, Y., Udagawa, N., Kobayashi, Y., Nakamura, M., Yamamoto, Y., Yamashita, T., Mizoguchi, T., Sato, M., Mogi, M., Penninger, JM., Takahashi, N. (2007). Osteoprotegerin reduces the serum level of receptor activator of NF-kappaB ligand derived from osteoblasts. J Immunol. 178(1):192-200 (abstract)
 
Nishio, M., Watanabe, K., Sasaki, J., Taya, C., Takasuga, S., Iizuka, R., Balla, T., Yamazaki, M., Watanabe, H., Itoh, R., Kuroda, S., Horie, Y., Förster, I., Mak, TW., Yonekawa, H., Penninger, JM., Kanaho, Y., Suzuki, A., Sasaki, T. (2007). Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1. Nat Cell Biol. 9(1):36-44 (abstract)
 
Oudit, GY., Kassiri, Z., Patel, MP., Chappell, M., Butany, J., Backx, PH., Tsushima, RG., Scholey, JW., Khokha, R., Penninger, JM. (2007). Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice. Cardiovasc Res. 75(1):29-39 (abstract)
 
Pospisilik, JA., Knauf, C., Joza, N., Benit, P., Orthofer, M., Cani, PD., Ebersberger, I., Nakashima, T., Sarao, R., Neely, G., Esterbauer, H., Kozlov, A., Kahn, CR., Kroemer, G., Rustin, P., Burcelin, R., Penninger, JM. (2007). Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes. Cell. 131(3):476-91 (abstract)
 
Rossi, SW., Kim, MY., Leibbrandt, A., Parnell, SM., Jenkinson, WE., Glanville, SH., McConnell, FM., Scott, HS., Penninger, JM., Jenkinson, EJ., Lane, PJ., Anderson, G. (2007). RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla. J Exp Med. 204(6):1267-72 (abstract)
 
Séverin, S., Gratacap, MP., Lenain, N., Alvarez, L., Hollande, E., Penninger, JM., Gachet, C., Plantavid, M., Payrastre, B. (2007). Deficiency of Src homology 2 domain-containing inositol 5-phosphatase 1 affects platelet responses and thrombus growth. J Clin Invest. 117(4):944-52 (abstract)
 
Shambharkar, PB., Blonska, M., Pappu, BP., Li, H., You, Y., Sakurai, H., Darnay, BG., Hara, H., Penninger, J., Lin, X. (2007). Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways. EMBO J. 26(7):1794-805 (abstract)
 
Tassi, I., Cella, M., Gilfillan, S., Turnbull, I., Diacovo, TG., Penninger, JM., Colonna, M. (2007). p110gamma and p110delta phosphoinositide 3-kinase signaling pathways synergize to control development and functions of murine NK cells. Immunity. 27(2):214-27 (abstract)
 
Wong, DW., Oudit, GY., Reich, H., Kassiri, Z., Zhou, J., Liu, QC., Backx, PH., Penninger, JM., Herzenberg, AM., Scholey, JW. (2007). Loss of angiotensin-converting enzyme-2 (Ace2) accelerates diabetic kidney injury. Am J Pathol. 171(2):438-51 (abstract)
 
Zhang, L., Anglesio, MS., O'Sullivan, M., Zhang, F., Yang, G., Sarao, R., Mai, PN., Cronin, S., Hara, H., Melnyk, N., Li, L., Wada, T., Liu, PP., Farrar, J., Arceci, RJ., Sorensen, PH., Penninger, JM. (2007). The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers. Nat Med. 13(9):1060-9 (abstract)
 
Zuber, AM., Singer, D., Penninger, JM., Rossier, BC., Firsov, D. (2007). Increased renal responsiveness to vasopressin and enhanced V2 receptor signaling in RGS2-/- mice. J Am Soc Nephrol. 18(6):1672-8 (abstract)
 
(2006)
 
Alnaeeli, M., Penninger, JM., Teng, YT. (2006). Immune interactions with CD4+ T cells promote the development of functional osteoclasts from murine CD11c+ dendritic cells. J Immunol. 177(5):3314-26 (abstract)
 
Atfield, AD., Liu, P., Penninger JM. (2006). The biochemical mechanisms of T-cell anergy Curr. Immunol. Rev.. 2:73-99
 
Brown, D., Yu, BD., Joza, N., Bénit, P., Meneses, J., Firpo, M., Rustin, P., Penninger, JM., Martin, GR. (2006). Loss of Aif function causes cell death in the mouse embryo, but the temporal progression of patterning is normal. Proc Natl Acad Sci U S A. 103(26):9918-23 (abstract)
 
Cheng, HY., Dziema, H., Papp, J., Mathur, DP., Koletar, M., Ralph, MR., Penninger, JM., Obrietan, K. (2006). The molecular gatekeeper Dexras1 sculpts the photic responsiveness of the mammalian circadian clock. J Neurosci. 26(50):12984-95 (abstract)
 
Cheng, H-Y.M, Penninger, JM. (2006). Dream/KchIP/ Calsenilin: a multifunctional player in health and disease. In Neuronal Calcium Sensor Proteins (Philippov, Koch, eds.); Nova Science Publishers. :245-270
 
Cheung, EC., Joza, N., Steenaart, NA., McClellan, KA., Neuspiel, M., McNamara, S., MacLaurin, JG., Rippstein, P., Park, DS., Shore, GC., McBride, HM., Penninger, JM., Slack, RS. (2006). Dissociating the dual roles of apoptosis-inducing factor in maintaining mitochondrial structure and apoptosis. EMBO J. 25(17):4061-73 (abstract)
 
Danilczyk, U., Penninger, JM. (2006). Angiotensin-converting enzyme II in the heart and the kidney. Circ Res. 98(4):463-71 (abstract)
 
Danilczyk, U., Sarao, R., Remy, C., Benabbas, C., Stange, G., Richter, A., Arya, S., Pospisilik, JA., Singer, D., Camargo, SM., Makrides, V., Ramadan, T., Verrey, F., Wagner, CA., Penninger, JM. (2006). Essential role for collectrin in renal amino acid transport. Nature. 444(7122):1088-91 (abstract)
 
Imai, Y., Kuba, K., Penninger, JM., (2006). The renin angiotensin system in acute respiratory distress syndrome. Drug Discovery Today. 3:225-229
 
Jones, DH., Nakashima, T., Sanchez, OH., Kozieradzki, I., Komarova, SV., Sarosi, I., Morony, S., Rubin, E., Sarao, R., Hojilla, CV., Komnenovic, V., Kong, YY., Schreiber, M., Dixon, SJ., Sims, SM., Khokha, R., Wada, T., Penninger, JM. (2006). Regulation of cancer cell migration and bone metastasis by RANKL. Nature. 440(7084):692-6 (abstract)
 
Kim, NS., Kim, HJ., Koo, BK., Kwon, MC., Kim, YW., Cho, Y., Yokota, Y., Penninger, JM., Kong, YY. (2006). Receptor activator of NF-kappaB ligand regulates the proliferation of mammary epithelial cells via Id2. Mol Cell Biol. 26(3):1002-13 (abstract)
 
Kuba, K., Imai, Y., Penninger, JM. (2006). Angiotensin-converting enzyme 2 in lung diseases. Curr Opin Pharmacol. 6(3):271-6 (abstract)
 
Kuba, K., Imai, Y., Penninger, JM. (2006). Angiotensin-converting enzyme 2 (ACE2)-mediated regulation of cardiovascular peptides and its application for treating disease. Experimental Medicine. 24:71-77
 
Kuba, K., Imai, Y., Penninger, JM. (2006). Angiotensin-converting enzyme 2 (ACE2)-mutant mice. Respiratory Molecular Medicine. 10:38-42
 
Kuba, K., Imai, Y., Rao, S., Jiang, C., Penninger, JM. (2006). Lessons from SARS: control of acute lung failure by the SARS receptor ACE2. J Mol Med (Berl). 84(10):814-20 (abstract)
 
Loser, K., Mehling, A., Loeser, S., Apelt, J., Kuhn, A., Grabbe, S., Schwarz, T., Penninger, JM., Beissert, S. (2006). Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells. Nat Med. 12(12):1372-9 (abstract)
 
Marty, RR., Dirnhofer, S., Mauermann, N., Schweikert, S., Akira, S., Hunziker, L., Penninger, JM., Eriksson, U. (2006). MyD88 signaling controls autoimmune myocarditis induction. Circulation. 113(2):258-65 (abstract)
 
Maruyama, K., Takada, Y., Ray, N., Kishimoto, Y., Penninger, JM., Yasuda, H., Matsuo, K. (2006). Receptor activator of NF-kappa B ligand and osteoprotegerin regulate proinflammatory cytokine production in mice. J Immunol. 177(6):3799-805 (abstract)
 
Nakashima T., Penninger, JM. (2006). Chemotactic regulation of cancer cell migration and bone metastases by RANKL. Experimental Medicine. 24:1777-80
 
Oudit, GY., Herzenberg, AM., Kassiri, Z., Wong, D., Reich, H., Khokha, R., Crackower, MA., Backx, PH., Penninger, JM., Scholey, JW. (2006). Loss of angiotensin-converting enzyme-2 leads to the late development of angiotensin II-dependent glomerulosclerosis. Am J Pathol. 168(6):1808-20 (abstract)
 
Rangachari, M., Mauermann, N., Marty, RR., Dirnhofer, S., Kurrer, MO., Komnenovic, V., Penninger, JM., Eriksson, U. (2006). T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17. J Exp Med. 203(8):2009-19 (abstract)
 
Roy, AA., Nunn, C., Ming, H., Zou, MX., Penninger, J., Kirshenbaum, LA., Dixon, SJ., Chidiac, P. (2006). Up-regulation of endogenous RGS2 mediates cross-desensitization between Gs and Gq signaling in osteoblasts. J Biol Chem. 281(43):32684-93 (abstract)
 
Sun, H., Kerfant, BG., Zhao, D., Trivieri, MG., Oudit, GY., Penninger, JM., Backx, PH. (2006). Insulin-like growth factor-1 and PTEN deletion enhance cardiac L-type Ca2+ currents via increased PI3Kalpha/PKB signaling. Circ Res. 98(11):1390-7 (abstract)
 
Valdés, G., Neves, LA., Anton, L., Corthorn, J., Chacón, C., Germain, AM., Merrill, DC., Ferrario, CM., Sarao, R., Penninger, J., Brosnihan, KB. (2006). Distribution of angiotensin-(1-7) and ACE2 in human placentas of normal and pathological pregnancies. Placenta. 27(2-3):200-7 (abstract)
 
Vorbach, C., Capecchi, MR., Penninger, JM. (2006). Evolution of the mammary gland from the innate immune system? Bioessays. 28(6):606-16 (abstract)
 
Wada, T., Nakashima, T., Hiroshi, N., Penninger, JM. (2006). RANKL-RANK signaling in osteoclastogenesis and bone disease. Trends Mol Med. 12(1):17-25 (abstract)
 
Yamamoto, Y., Udagawa, N., Matsuura, S., Nakamichi, Y., Horiuchi, H., Hosoya, A., Nakamura, M., Ozawa, H., Takaoka, K., Penninger, JM., Noguchi, T., Takahashi, N. (2006). Osteoblasts provide a suitable microenvironment for the action of receptor activator of nuclear factor-kappaB ligand. Endocrinology. 147(7):3366-74 (abstract)
 
Zhao, M., Song, B., Pu, J., Wada, T., Reid, B., Tai, G., Wang, F., Guo, A., Walczysko, P., Gu, Y., Sasaki, T., Suzuki, A., Forrester, JV., Bourne, HR., Devreotes, PN., McCaig, CD., Penninger, JM. (2006). Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature. 442(7101):457-60 (abstract)
 
(2005)
 
Bachmaier, K., Penninger, JM. (2005). Chlamydia and antigenic mimicry. Curr Top Microbiol Immunol. 296:153-63 (abstract)
 
Eriksson, U., Kopf, M., Afanasyeva, M., Penninger, JM. (2005). Models of autoimmune heart disease: a review of current status. Drug Discovery Today: Disease Models, online edition.
 
Eriksson, U., Penninger, JM. (2005). Autoimmune heart failure: new understandings of pathogenesis. Int J Biochem Cell Biol. 37(1):27-32 (abstract)
 
Eriksson, U., Penninger, JM., Kopf, M. (2005). Autoimmune heart disease: from bench to bedside. Drug Discovery Today: Disease Mechanisms, online edition.
 
Imai, Y., Kuba, K., Rao, S., Huan, Y., Guo, F., Guan, B., Yang, P., Sarao, R., Wada, T., Leong-Poi, H., Crackower, MA., Fukamizu, A., Hui, CC., Hein, L., Uhlig, S., Slutsky, AS., Jiang, C., Penninger, JM. (2005). Angiotensin-converting enzyme 2 protects from severe acute lung failure. Nature. 436(7047):112-6 (abstract)
 
Joza, N., Oudit, GY., Brown, D., Bénit, P., Kassiri, Z., Vahsen, N., Benoit, L., Patel, MM., Nowikovsky, K., Vassault, A., Backx, PH., Wada, T., Kroemer, G., Rustin, P., Penninger, JM. (2005). Muscle-specific loss of apoptosis-inducing factor leads to mitochondrial dysfunction, skeletal muscle atrophy, and dilated cardiomyopathy. Mol Cell Biol. 25(23):10261-72 (abstract)
 
Kerfant, BG., Gidrewicz, D., Sun, H., Oudit, GY., Penninger, JM., Backx, PH. (2005). Cardiac sarcoplasmic reticulum calcium release and load are enhanced by subcellular cAMP elevations in PI3Kgamma-deficient mice. Circ Res. 96(10):1079-86 (abstract)
 
Kolas, NK., Marcon, E., Crackower, MA., Höög, C., Penninger, JM., Spyropoulos, B., Moens, PB. (2005). Mutant meiotic chromosome core components in mice can cause apparent sexual dimorphic endpoints at prophase or X-Y defective male-specific sterility. Chromosoma. 114(2):92-102 (abstract)
 
Krawczyk, CM., Jones, RG., Atfield, A., Bachmaier, K., Arya, S., Odermatt, B., Ohashi, PS., Penninger, JM. (2005). Differential control of CD28-regulated in vivo immunity by the E3 ligase Cbl-b. J Immunol. 174(3):1472-8 (abstract)
 
Kuba, K., Imai, Y., Penninger, JM. (2005). Angiotensin converting enzyme 2 (ACE2) and SARS infections. Experimental Medicine. 23:2830-5
 
Kuba, K., Imai, Y., Rao, S., Gao, H., Guo, F., Guan, B., Huan, Y., Yang, P., Zhang, Y., Deng, W., Bao, L., Zhang, B., Liu, G., Wang, Z., Chappell, M., Liu, Y., Zheng, D., Leibbrandt, A., Wada, T., Slutsky, AS., Liu, D., Qin, C., Jiang, C., Penninger, JM. (2005). A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nat Med. 11(8):875-9 (abstract)
 
Liu, YC., Penninger, J., Karin, M. (2005). Immunity by ubiquitylation: a reversible process of modification. Nat Rev Immunol. 5(12):941-52 (abstract)
 
Mahamed, DA., Marleau, A., Alnaeeli, M., Singh, B., Zhang, X., Penninger, JM., Teng, YT. (2005). G(-) anaerobes-reactive CD4+ T-cells trigger RANKL-mediated enhanced alveolar bone loss in diabetic NOD mice. Diabetes. 54(5):1477-86 (abstract)
 
Puri, KD., Doggett, TA., Huang, CY., Douangpanya, J., Hayflick, JS., Turner, M., Penninger, J., Diacovo, TG. (2005). The role of endothelial PI3Kgamma activity in neutrophil trafficking. Blood. 106(1):150-7 (abstract)
 
Rangachari, M., Eriksson, U., Vollmann, EH., Penninger, JM. (2005). A novel model for pathogenesis of autoimmune heart failure: the role of dendritic cells. International Congress Series (Uehara Foundation Review). 1285:192-201
 
Ricci, R., Eriksson, U., Oudit, GY., Eferl, R., Akhmedov, A., Sumara, I., Sumara, G., Kassiri, Z., David, JP., Bakiri, L., Sasse, B., Idarraga, MH., Rath, M., Kurz, D., Theussl, HC., Perriard, JC., Backx, P., Penninger, JM., Wagner, EF. (2005). Distinct functions of junD in cardiac hypertrophy and heart failure. Genes Dev. 19(2):208-13 (abstract)
 
Sasaki, J., Sasaki, T., Yamazaki, M., Matsuoka, K., Taya, C., Shitara, H., Takasuga, S., Nishio, M., Mizuno, K., Wada, T., Miyazaki, H., Watanabe, H., Iizuka, R., Kubo, S., Murata, S., Chiba, T., Maehama, T., Hamada, K., Kishimoto, H., Frohman, MA., Tanaka, K., Penninger, JM., Yonekawa, H., Suzuki, A., Kanaho, Y. (2005). Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I {alpha}. J Exp Med. 201(6):859-70 (abstract)
 
Wada, T., Nakashima, T., Oliveira-dos-Santos, AJ., Gasser, J., Hara, H., Schett, G., Penninger, JM. (2005). The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis. Nat Med. 11(4):394-9 (abstract)
 
Wang, X., Zeng, W., Soyombo, AA., Tang, W., Ross, EM., Barnes, AP., Milgram, SL., Penninger, JM., Allen, PB., Greengard, P., Muallem, S. (2005). Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors. Nat Cell Biol. 7(4):405-11 (abstract)
 
Wilson, LD., Ross, SA., Lepore, DA., Wada, T., Penninger, JM., Thomas, PQ. (2005). Developmentally regulated expression of the regulator of G-protein signaling gene 2 (Rgs2) in the embryonic mouse pituitary. Gene Expr Patterns. 5(3):305-11 (abstract)
 
(2004)
 
Anglesio, MS., Evdokimova, V., Melnyk, N., Zhang, L., Fernandez, CV., Grundy, PE., Leach, S., Marra, MA., Brooks-Wilson, AR., Penninger, J., Sorensen, PH. (2004). Differential expression of a novel ankyrin containing E3 ubiquitin-protein ligase, Hace1, in sporadic Wilms' tumor versus normal kidney. Hum Mol Genet. 13(18):2061-74 (abstract)
 
Candé, C., Vahsen, N., Kouranti, I., Schmitt, E., Daugas, E., Spahr, C., Luban, J., Kroemer, RT., Giordanetto, F., Garrido, C., Penninger, JM., Kroemer, G. (2004). AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis. Oncogene. 23(8):1514-21 (abstract)
 
Cheng, HY., Laviolette, SR., van der Kooy, D., Penninger, JM. (2004). DREAM ablation selectively alters THC place aversion and analgesia but leaves intact the motivational and analgesic effects of morphine. Eur J Neurosci. 19(11):3033-41 (abstract)
 
Cheng, HY., Obrietan, K., Cain, SW., Lee, BY., Agostino, PV., Joza, NA., Harrington, ME., Ralph, MR., Penninger, JM. (2004). Dexras1 potentiates photic and suppresses nonphotic responses of the circadian clock. Neuron. 43(5):715-28 (abstract)
 
Cheng, HY., Penninger, JM. (2004). DREAMing about arthritic pain. Ann Rheum Dis. 63 Suppl 2:ii72-ii75 (abstract)
 
Danilczyk, U., Eriksson, U., Oudit, GY., Penninger, JM. (2004). Physiological roles of angiotensin-converting enzyme 2. Cell Mol Life Sci. 61(21):2714-9 (abstract)
 
Danilczyk, U., Penninger, J. (2004). Hypertension with a grain of salt. Nat Med. 10(11):1163-4 (abstract)
 
Fischer, L., Gukovskaya, AS., Young, SH., Gukovsky, I., Lugea, A., Buechler, P., Penninger, JM., Friess, H., Pandol, SJ. (2004). Phosphatidylinositol 3-kinase regulates Ca2+ signaling in pancreatic acinar cells through inhibition of sarco(endo)plasmic reticulum Ca2+-ATPase. Am J Physiol Gastrointest Liver Physiol. 287(6):G1200-12 (abstract)
 
Gronski, MA., Boulter, JM., Moskophidis, D., Nguyen, LT., Holmberg, K., Elford, AR., Deenick, EK., Kim, HO., Penninger, JM., Odermatt, B., Gallimore, A., Gascoigne, NR., Ohashi, PS. (2004). TCR affinity and negative regulation limit autoimmunity. Nat Med. 10(11):1234-9 (abstract)
 
Gukovsky, I., Cheng, JH., Nam, KJ., Lee, OT., Lugea, A., Fischer, L., Penninger, JM., Pandol, SJ., Gukovskaya, AS. (2004). Phosphatidylinositide 3-kinase gamma regulates key pathologic responses to cholecystokinin in pancreatic acinar cells. Gastroenterology. 126(2):554-66 (abstract)
 
Hara, H., Bakal, C., Wada, T., Bouchard, D., Rottapel, R., Saito, T., Penninger, JM. (2004). The molecular adapter Carma1 controls entry of IkappaB kinase into the central immune synapse. J Exp Med. 200(9):1167-77 (abstract)
 
Jeon, MS., Atfield, A., Venuprasad, K., Krawczyk, C., Sarao, R., Elly, C., Yang, C., Arya, S., Bachmaier, K., Su, L., Bouchard, D., Jones, R., Gronski, M., Ohashi, P., Wada, T., Bloom, D., Fathman, CG., Liu, YC., Penninger, JM. (2004). Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction. Immunity. 21(2):167-77 (abstract)
 
Marra, LE., Zhang, ZX., Joe, B., Campbell, J., Levy, GA., Penninger, J., Zhang, L. (2004). IL-10 induces regulatory T cell apoptosis by up-regulation of the membrane form of TNF-alpha. J Immunol. 172(2):1028-35 (abstract)
 
Martin-McCaffrey, L., Willard, FS., Oliveira-dos-Santos, AJ., Natale, DR., Snow, BE., Kimple, RJ., Pajak, A., Watson, AJ., Dagnino, L., Penninger, JM., Siderovski, DP., D'Souza, SJ. (2004). RGS14 is a mitotic spindle protein essential from the first division of the mammalian zygote. Dev Cell. 7(5):763-9 (abstract)
 
Matsumoto, G., Kubota, E., Omi, Y., Lee, U., Penninger, JM. (2004). Essential role of LFA-1 in activating Th2-like responses by alpha-galactosylceramide-activated NKT cells. J Immunol. 173(8):4976-84 (abstract)
 
Nishitai, G., Shimizu, N., Negishi, T., Kishimoto, H., Nakagawa, K., Kitagawa, D., Watanabe, T., Momose, H., Ohata, S., Tanemura, S., Asaka, S., Kubota, J., Saito, R., Yoshida, H., Mak, TW., Wada, T., Penninger, JM., Azuma, N., Nishina, H., Katada, T. (2004). Stress induces mitochondria-mediated apoptosis independent of SAPK/JNK activation in embryonic stem cells. J Biol Chem. 279(3):1621-6 (abstract)
 
Oudit, GY., Sun, H., Kerfant, BG., Crackower, MA., Penninger, JM., Backx, PH. (2004). The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease. J Mol Cell Cardiol. 37(2):449-71 (abstract)
 
Perfettini, JL., Roumier, T., Castedo, M., Larochette, N., Boya, P., Raynal, B., Lazar, V., Ciccosanti, F., Nardacci, R., Penninger, J., Piacentini, M., Kroemer, G. (2004). NF-kappaB and p53 are the dominant apoptosis-inducing transcription factors elicited by the HIV-1 envelope. J Exp Med. 199(5):629-40 (abstract)
 
Rangachari, M., Penninger, JM. (2004). Negative regulation of T cell receptor signals. Curr Opin Pharmacol. 4(4):415-22 (abstract)
 
Reif, K., Okkenhaug, K., Sasaki, T., Penninger, JM., Vanhaesebroeck, B., Cyster, JG. (2004). Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing. J Immunol. 173(4):2236-40 (abstract)
 
Vahsen, N., Candé, C., Brière, JJ., Bénit, P., Joza, N., Larochette, N., Mastroberardino, PG., Pequignot, MO., Casares, N., Lazar, V., Feraud, O., Debili, N., Wissing, S., Engelhardt, S., Madeo, F., Piacentini, M., Penninger, JM., Schägger, H., Rustin, P., Kroemer, G. (2004). AIF deficiency compromises oxidative phosphorylation. EMBO J. 23(23):4679-89 (abstract)
 
Wada, T., Joza, N., Cheng, HY., Sasaki, T., Kozieradzki, I., Bachmaier, K., Katada, T., Schreiber, M., Wagner, EF., Nishina, H., Penninger, JM. (2004). MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence. Nat Cell Biol. 6(3):215-26 (abstract)
 
Wada, T., Nishina, H., Katada, T., Penninger, JM. (2004). MKK7 couples stress signalling to G2/M cell cycle progression and cellular senescence. Exper. Med. . 22:1398-400
 
Wada, T., Penninger, JM. (2004). Mitogen-activated protein kinases in apoptosis regulation. Oncogene. 23(16):2838-49 (abstract)
 
Wada, T., Penninger, JM. (2004). Stress kinase MKK7: savior of cell cycle arrest and cellular senescence. Cell Cycle. 3(5):577-9 (abstract)
 
Wang, X., Huang, G., Luo, X., Penninger, JM., Muallem, S. (2004). Role of regulator of G protein signaling 2 (RGS2) in Ca(2+) oscillations and adaptation of Ca(2+) signaling to reduce excitability of RGS2-/- cells. J Biol Chem. 279(40):41642-9 (abstract)
 
(2003)
 
Brosnihan, KB., Neves, LA., Joyner, J., Averill, DB., Chappell, MC., Sarao, R., Penninger, J., Ferrario, CM. (2003). Enhanced renal immunocytochemical expression of ANG-(1-7) and ACE2 during pregnancy. Hypertension. 42(4):749-53 (abstract)
 
Cheng, HY., Penninger, JM. (2003). When the DREAM is gone: from basic science to future prospectives in pain management and beyond. Expert Opin Ther Targets. 7(2):249-63 (abstract)
 
Crackower, MA., Kolas, NK., Noguchi, J., Sarao, R., Kikuchi, K., Kaneko, H., Kobayashi, E., Kawai, Y., Kozieradzki, I., Landers, R., Mo, R., Hui, CC., Nieves, E., Cohen, PE., Osborne, LR., Wada, T., Kunieda, T., Moens, PB., Penninger, JM. (2003). Essential role of Fkbp6 in male fertility and homologous chromosome pairing in meiosis. Science. 300(5623):1291-5 (abstract)
 
Danilczyk, U., Eriksson, U., Crackower, MA., Penninger, JM. (2003). A story of two ACEs. J Mol Med (Berl). 81(4):227-34 (abstract)
 
Eriksson, U., Kurrer, MO., Sonderegger, I., Iezzi, G., Tafuri, A., Hunziker, L., Suzuki, S., Bachmaier, K., Bingisser, RM., Penninger, JM., Kopf, M. (2003). Activation of dendritic cells through the interleukin 1 receptor 1 is critical for the induction of autoimmune myocarditis. J Exp Med. 197(3):323-31 (abstract)
 
Eriksson, U., Ricci, R., Hunziker, L., Kurrer, MO., Oudit, GY., Watts, TH., Sonderegger, I., Bachmaier, K., Kopf, M., Penninger, JM. (2003). Dendritic cell-induced autoimmune heart failure requires cooperation between adaptive and innate immunity. Nat Med. 9(12):1484-90 (abstract)
 
Giuriato, S., Pesesse, X., Bodin, S., Sasaki, T., Viala, C., Marion, E., Penninger, J., Schurmans, S., Erneux, C., Payrastre, B. (2003). SH2-containing inositol 5-phosphatases 1 and 2 in blood platelets: their interactions and roles in the control of phosphatidylinositol 3,4,5-trisphosphate levels. Biochem J. 376(Pt 1):199-207 (abstract)
 
Gonzalez-Espinosa, C., Odom, S., Olivera, A., Hobson, JP., Martinez, ME., Oliveira-Dos-Santos, A., Barra, L., Spiegel, S., Penninger, JM., Rivera, J. (2003). Preferential signaling and induction of allergy-promoting lymphokines upon weak stimulation of the high affinity IgE receptor on mast cells. J Exp Med. 197(11):1453-65 (abstract)
 
Griffiths, EK., Sanchez, O., Mill, P., Krawczyk, C., Hojilla, CV., Rubin, E., Nau, MM., Khokha, R., Lipkowitz, S., Hui, CC., Penninger, JM. (2003). Cbl-3-deficient mice exhibit normal epithelial development. Mol Cell Biol. 23(21):7708-18 (abstract)
 
Hara, H., Wada, T., Bakal, C., Kozieradzki, I., Suzuki, S., Suzuki, N., Nghiem, M., Griffiths, EK., Krawczyk, C., Bauer, B., D'Acquisto, F., Ghosh, S., Yeh, WC., Baier, G., Rottapel, R., Penninger, JM. (2003). The MAGUK family protein CARD11 is essential for lymphocyte activation. Immunity. 18(6):763-75 (abstract)
 
Heximer, SP., Knutsen, RH., Sun, X., Kaltenbronn, KM., Rhee, MH., Peng, N., Oliveira-dos-Santos, A., Penninger, JM., Muslin, AJ., Steinberg, TH., Wyss, JM., Mecham, RP., Blumer, KJ. (2003). Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice. J Clin Invest. 111(8):1259 (abstract)
 
Irie-Sasaki, J., Sasaki, T., Penninger, JM. (2003). CD45 regulated signaling pathways. Curr Top Med Chem. 3(7):783-96 (abstract)
 
Jun, JE., Wilson, LE., Vinuesa, CG., Lesage, S., Blery, M., Miosge, LA., Cook, MC., Kucharska, EM., Hara, H., Penninger, JM., Domashenz, H., Hong, NA., Glynne, RJ., Nelms, KA., Goodnow, CC. (2003). Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis. Immunity. 18(6):751-62 (abstract)
 
Kim, C., Marchal, CC., Penninger, J., Dinauer, MC. (2003). The hemopoietic Rho/Rac guanine nucleotide exchange factor Vav1 regulates N-formyl-methionyl-leucyl-phenylalanine-activated neutrophil functions. J Immunol. 171(8):4425-30 (abstract)
 
Kishimoto, H., Nakagawa, K., Watanabe, T., Kitagawa, D., Momose, H., Seo, J., Nishitai, G., Shimizu, N., Ohata, S., Tanemura, S., Asaka, S., Goto, T., Fukushi, H., Yoshida, H., Suzuki, A., Sasaki, T., Wada, T., Penninger, JM., Nishina, H., Katada, T. (2003). Different properties of SEK1 and MKK7 in dual phosphorylation of stress-induced activated protein kinase SAPK/JNK in embryonic stem cells. J Biol Chem. 278(19):16595-601 (abstract)
 
Nakashima, T., Wada, T., Penninger, JM. (2003). RANKL and RANK as novel therapeutic targets for arthritis. Curr Opin Rheumatol. 15(3):280-7 (abstract)
 
Oudit, GY., Crackower, MA., Backx, PH., Penninger, JM. (2003). The role of ACE2 in cardiovascular physiology. Trends Cardiovasc Med. 13(3):93-101 (abstract)
 
Oudit, GY., Crackower, MA., Eriksson, U., Sarao, R., Kozieradzki, I., Sasaki, T., Irie-Sasaki, J., Gidrewicz, D., Rybin, VO., Wada, T., Steinberg, SF., Backx, PH., Penninger, JM. (2003). Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure. Circulation. 108(17):2147-52 (abstract)
 
Penninger, JM., Kroemer, G. (2003). Mitochondria, AIF and caspases--rivaling for cell death execution. Nat Cell Biol. 5(2):97-9 (abstract)
 
Saibil, SD., Ohteki, T., White, FM., Luscher, M., Zakarian, A., Elford, A., Shabanowitz, J., Nishina, H., Hugo, P., Penninger, J., Barber, B., Hunt, DF., Ohashi, PS. (2003). Weak agonist self-peptides promote selection and tuning of virus-specific T cells. Eur J Immunol. 33(3):685-96 (abstract)
 
Schmitt, E., Parcellier, A., Gurbuxani, S., Cande, C., Hammann, A., Morales, MC., Hunt, CR., Dix, DJ., Kroemer, RT., Giordanetto, F., Jäättelä, M., Penninger, JM., Pance, A., Kroemer, G., Garrido, C. (2003). Chemosensitization by a non-apoptogenic heat shock protein 70-binding apoptosis-inducing factor mutant. Cancer Res. 63(23):8233-40 (abstract)
 
Suzuki, N., Chen, NJ., Millar, DG., Suzuki, S., Horacek, T., Hara, H., Bouchard, D., Nakanishi, K., Penninger, JM., Ohashi, PS., Yeh, WC. (2003). IL-1 receptor-associated kinase 4 is essential for IL-18-mediated NK and Th1 cell responses. J Immunol. 170(8):4031-5 (abstract)
 
Suzuki, N., Suzuki, S., Eriksson, U., Hara, H., Mirtosis, C., Chen, NJ., Wada, T., Bouchard, D., Hwang, I., Takeda, K., Fujita, T., Der, S., Penninger, JM., Akira, S., Saito, T., Yeh, WC. (2003). IL-1R-associated kinase 4 is required for lipopolysaccharide-induced activation of APC. J Immunol. 171(11):6065-71 (abstract)
 
(2002)
 
Cheng, H.-YM., Penninger, JM. (2002). Transcriptional mechanisms underlying neuropathic pain: DREAM, transcription factors and future pain management? Exp. Rev. Neurotherapeutics. 2:677-89
 
Cheng, HY., Pitcher, GM., Laviolette, SR., Whishaw, IQ., Tong, KI., Kockeritz, LK., Wada, T., Joza, NA., Crackower, M., Goncalves, J., Sarosi, I., Woodgett, JR., Oliveira-dos-Santos, AJ., Ikura, M., van der Kooy, D., Salter, MW., Penninger, JM. (2002). DREAM is a critical transcriptional repressor for pain modulation. Cell. 108(1):31-43 (abstract)
 
Crackower, MA., Oudit, GY., Kozieradzki, I., Sarao, R., Sun, H., Sasaki, T., Hirsch, E., Suzuki, A., Shioi, T., Irie-Sasaki, J., Sah, R., Cheng, HY., Rybin, VO., Lembo, G., Fratta, L., Oliveira-dos-Santos, AJ., Benovic, JL., Kahn, CR., Izumo, S., Steinberg, SF., Wymann, MP., Backx, PH., Penninger, JM. (2002). Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell. 110(6):737-49 (abstract)
 
Crackower, MA., Sarao, R., Oudit, GY., Yagil, C., Kozieradzki, I., Scanga, SE., Oliveira-dos-Santos, AJ., da Costa, J., Zhang, L., Pei, Y., Scholey, J., Ferrario, CM., Manoukian, AS., Chappell, MC., Backx, PH., Yagil, Y., Penninger, JM. (2002). Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature. 417(6891):822-8 (abstract)
 
Eriksson, U., Danilczyk, U., Penninger, JM. (2002). Just the beginning: novel functions for angiotensin-converting enzymes. Curr Biol. 12(21):R745-52 (abstract)
 
Griffiths, EK., Penninger, JM. (2002). Communication between the TCR and integrins: role of the molecular adapter ADAP/Fyb/Slap. Curr Opin Immunol. 14(3):317-22 (abstract)
 
Griffiths, EK., Penninger, JM. (2002). ADAP-ting TCR signaling to integrins. Sci STKE. 2002(127):re3 (abstract)
 
Ito, N., Yokomizo, T., Sasaki, T., Kurosu, H., Penninger, J., Kanaho, Y., Katada, T., Hanaoka, K., Shimizu, T. (2002). Requirement of phosphatidylinositol 3-kinase activation and calcium influx for leukotriene B4-induced enzyme release. J Biol Chem. 277(47):44898-904 (abstract)
 
Jones, DH., Kong, YY., Penninger, JM. (2002). Role of RANKL and RANK in bone loss and arthritis. Ann Rheum Dis. 61 Suppl 2:ii32-9 (abstract)
 
Joza, N., Kroemer, G., Penninger, JM. (2002). Genetic analysis of the mammalian cell death machinery. Trends Genet. 18(3):142-9 (abstract)
 
Kim, HJ., Yoon, MJ., Lee, J., Penninger, JM., Kong, YY. (2002). Osteoprotegerin ligand induces beta-casein gene expression through the transcription factor CCAAT/enhancer-binding protein beta. J Biol Chem. 277(7):5339-44 (abstract)
 
Krawczyk, C., Oliveira-dos-Santos, A., Sasaki, T., Griffiths, E., Ohashi, PS., Snapper, S., Alt, F., Penninger, JM. (2002). Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells. Immunity. 16(3):331-43 (abstract)
 
Kurrer, MO., Kopf, M., Penninger, JM., Eriksson, U. (2002). Cytokines that regulate autoimmune myocarditis. Swiss Med Wkly. 132(29-30):408-13 (abstract)
 
Maté, MJ., Ortiz-Lombardía, M., Boitel, B., Haouz, A., Tello, D., Susin, SA., Penninger, J., Kroemer, G., Alzari, PM. (2002). The crystal structure of the mouse apoptosis-inducing factor AIF. Nat Struct Biol. 9(6):442-6 (abstract)
 
Matsumoto, G., Tsunematsu, S., Tsukinoki, K., Ohmi, Y., Iwamiya, M., Oliveira-dos-Santos, A., Tone, D., Shindo, J., Penninger, JM. (2002). Essential role of the adhesion receptor LFA-1 for T cell-dependent fulminant hepatitis. J Immunol. 169(12):7087-96 (abstract)
 
Opavsky, MA., Martino, T., Rabinovitch, M., Penninger, J., Richardson, C., Petric, M., Trinidad, C., Butcher, L., Chan, J., Liu, PP. (2002). Enhanced ERK-1/2 activation in mice susceptible to coxsackievirus-induced myocarditis. J Clin Invest. 109(12):1561-9 (abstract)
 
Penninger, JM., Bachmaier, K. (2002). Infections and the immune response to cardiac antigens. Book chapter. Epitope recognition since Landsteiner's discovery - 100 years since the discovery of human blood groups (Eibl, M., Mayr, WR., Thorbecke, GJ., eds.). :103-17
 
Roumier, T., Vieira, HL., Castedo, M., Ferri, KF., Boya, P., Andreau, K., Druillennec, S., Joza, N., Penninger, JM., Roques, B., Kroemer, G. (2002). The C-terminal moiety of HIV-1 Vpr induces cell death via a caspase-independent mitochondrial pathway. Cell Death Differ. 9(11):1212-9 (abstract)
 
Sasaki, T., Sasaki-Irie, J., Penninger, JM. (2002). The potential role of CD45 as a drug target. Curr. Topics Med. Chem.. 131:495-501
 
Sasaki, T., Suzuki, A., Sasaki, J., Penninger, JM. (2002). Phosphoinositide 3-kinases in immunity: lessons from knockout mice. J Biochem. 131(4):495-501 (abstract)
 
Suzuki, N., Suzuki, S., Duncan, GS., Millar, DG., Wada, T., Mirtsos, C., Takada, H., Wakeham, A., Itie, A., Li, S., Penninger, JM., Wesche, H., Ohashi, PS., Mak, TW., Yeh, WC. (2002). Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. Nature. 416(6882):750-6 (abstract)
 
Tani-Ishii, N., Penninger, JM., Matsumoto, G., Teranaka, T., Umemoto, T. (2002). The role of LFA-1 in osteoclast development induced by co-cultures of mouse bone marrow cells and MC3T3-G2/PA6 cells. J Periodontal Res. 37(3):184-91 (abstract)
 
Theill, LE., Boyle, WJ., Penninger, JM. (2002). RANK-L and RANK: T cells, bone loss, and mammalian evolution. Annu Rev Immunol. 20:795-823 (abstract)
 
Watanabe, T., Nakagawa, K., Ohata, S., Kitagawa, D., Nishitai, G., Seo, J., Tanemura, S., Shimizu, N., Kishimoto, H., Wada, T., Aoki, J., Arai, H., Iwatsubo, T., Mochita, M., Watanabe, T., Satake, M., Ito, Y., Matsuyama, T., Mak, TW., Penninger, JM., Nishina, H., Katada, T. (2002). SEK1/MKK4-mediated SAPK/JNK signaling participates in embryonic hepatoblast proliferation via a pathway different from NF-kappaB-induced anti-apoptosis. Dev Biol. 250(2):332-47 (abstract)