Josef Penninger

Picture of the IMBA Director and Group Leader Josef Penninger

Bones, immunity and cancer

  • The basic approach of the Penninger group is to genetically manipulate and change genes in mice and to determine the effects of these mutations on the development of the whole organism and in diseases. His group has also developed new models in flies to model diseases at the whole genome level and compare such models with human SNP maps. From these studies, the team is trying to establish basic principles of physiology and basic mechanisms of disease pathogenesis. In particular, the Penninger laboratory focuses on heart and lung diseases, cancer, and bone diseases.

  • Contact:

    Josef Penninger
    Senior Scientist and Scientific Director
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    Sandra Prassel
    Assistant to Josef Penninger
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Selected Publications

(2012)
 
Hashimoto, T., Perlot, T., Rehman, A., Trichereau, J., Ishiguro, H., Paolino, M., Sigl, V., Hanada, T., Hanada, R., Lipinski, S., Wild, B., Camargo, SM., Singer, D., Richter, A., Kuba, K., Fukamizu, A., Schreiber, S., Clevers, H., Verrey, F., Rosenstiel, P., Penninger, JM. (2012). ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature. 487(7408):477-81 (abstract)
 
(2010)
 
Neely, GG., Hess, A., Costigan, M., Keene, AC., Goulas, S., Langeslag, M., Griffin, RS., Belfer, I., Dai, F., Smith, SB., Diatchenko, L., Gupta, V., Xia, CP., Amann, S., Kreitz, S., Heindl-Erdmann, C., Wolz, S., Ly, CV., Arora, S., Sarangi, R., Dan, D., Novatchkova, M., Rosenzweig, M., Gibson, DG., Truong, D., Schramek, D., Zoranovic, T., Cronin, SJ., Angjeli, B., Brune, K., Dietzl, G., Maixner, W., Meixner, A., Thomas, W., Pospisilik, JA., Alenius, M., Kress, M., Subramaniam, S., Garrity, PA., Bellen, HJ., Woolf, CJ., Penninger, JM. (2010). A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. Cell. 143(4):628-38 (abstract)
 
Neely, GG., Kuba, K., Cammarato, A., Isobe, K., Amann, S., Zhang, L., Murata, M., Elmén, L., Gupta, V., Arora, S., Sarangi, R., Dan, D., Fujisawa, S., Usami, T., Xia, CP., Keene, AC., Alayari, NN., Yamakawa, H., Elling, U., Berger, C., Novatchkova, M., Koglgruber, R., Fukuda, K., Nishina, H., Isobe, M., Pospisilik, JA., Imai, Y., Pfeufer, A., Hicks, AA., Pramstaller, PP., Subramaniam, S., Kimura, A., Ocorr, K., Bodmer, R., Penninger, JM. (2010). A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Cell. 141(1):142-53 (abstract)
 
Pospisilik, JA., Schramek, D., Schnidar, H., Cronin, SJ., Nehme, NT., Zhang, X., Knauf, C., Cani, PD., Aumayr, K., Todoric, J., Bayer, M., Haschemi, A., Puviindran, V., Tar, K., Orthofer, M., Neely, GG., Dietzl, G., Manoukian, A., Funovics, M., Prager, G., Wagner, O., Ferrandon, D., Aberger, F., Hui, CC., Esterbauer, H., Penninger, JM. (2010). Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. Cell. 140(1):148-60 (abstract)
 
Schramek, D., Leibbrandt, A., Sigl, V., Kenner, L., Pospisilik, JA., Lee, HJ., Hanada, R., Joshi, PA., Aliprantis, A., Glimcher, L., Pasparakis, M., Khokha, R., Ormandy, CJ., Widschwendter, M., Schett, G., Penninger, JM. (2010). Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer. Nature. 468(7320):98-102 (abstract)
 
(2009)
 
Hanada, R., Leibbrandt, A., Hanada, T., Kitaoka, S., Furuyashiki, T., Fujihara, H., Trichereau, J., Paolino, M., Qadri, F., Plehm, R., Klaere, S., Komnenovic, V., Mimata, H., Yoshimatsu, H., Takahashi, N., von Haeseler, A., Bader, M., Kilic, SS., Ueta, Y., Pifl, C., Narumiya, S., Penninger, JM. (2009). Central control of fever and female body temperature by RANKL/RANK. Nature. 462(7272):505-9 (abstract)