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Josef Penninger

Picture of the IMBA Director and Group Leader Josef Penninger

Bones, immunity and cancer

The basic approach of the Penninger group is to genetically manipulate and change genes in mice and to determine the effects of these mutations on the development of the whole organism and in diseases. His group has also developed new models in flies to model diseases at the whole genome level and compare such models with human SNP maps. From these studies, the team is trying to establish basic principles of physiology and basic mechanisms of disease pathogenesis. In particular, the Penninger laboratory focuses on heart and lung diseases, cancer, and bone diseases.


Contact:

Josef Penninger
Senior Scientist and Scientific Director


Erika Wood
Assistant to Josef Penninger

(2009)
 
Cronin, SJ., Nehme, NT., Limmer, S., Liegeois, S., Pospisilik, JA., Schramek, D., Leibbrandt, A., Simoes, Rde M., Gruber, S., Puc, U., Ebersberger, I., Zoranovic, T., Neely, GG., von Haeseler, A., Ferrandon, D., Penninger, JM. (2009). Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection. Science. 325(5938):340-3 (abstract)
 
(2008)
 
Imai, Y., Kuba, K., Neely, GG., Yaghubian-Malhami, R., Perkmann, T., van Loo, G., Ermolaeva, M., Veldhuizen, R., Leung, YH., Wang, H., Liu, H., Sun, Y., Pasparakis, M., Kopf, M., Mech, C., Bavari, S., Peiris, JS., Slutsky, AS., Akira, S., Hultqvist, M., Holmdahl, R., Nicholls, J., Jiang, C., Binder, CJ., Penninger, JM. (2008). Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell. 133(2):235-49 (abstract)
 
(2007)
 
Pospisilik, JA., Knauf, C., Joza, N., Benit, P., Orthofer, M., Cani, PD., Ebersberger, I., Nakashima, T., Sarao, R., Neely, G., Esterbauer, H., Kozlov, A., Kahn, CR., Kroemer, G., Rustin, P., Burcelin, R., Penninger, JM. (2007). Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes. Cell. 131(3):476-91 (abstract)
 
Zhang, L., Anglesio, MS., O'Sullivan, M., Zhang, F., Yang, G., Sarao, R., Mai, PN., Cronin, S., Hara, H., Melnyk, N., Li, L., Wada, T., Liu, PP., Farrar, J., Arceci, RJ., Sorensen, PH., Penninger, JM. (2007). The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers. Nat Med. 13(9):1060-9 (abstract)
 
(2006)
 
Danilczyk, U., Sarao, R., Remy, C., Benabbas, C., Stange, G., Richter, A., Arya, S., Pospisilik, JA., Singer, D., Camargo, SM., Makrides, V., Ramadan, T., Verrey, F., Wagner, CA., Penninger, JM. (2006). Essential role for collectrin in renal amino acid transport. Nature. 444(7122):1088-91 (abstract)