2015

Akbari, OS., Bellen, HJ., Bier, E., Bullock, SL., Burt, A., Church, GM., Cook, KR., Duchek, P., Edwards, OR., Esvelt, KM., Gantz, VM., Golic, KG., Gratz, SJ., Harrison, MM., Hayes, KR., James, AA., Kaufman, TC., Knoblich, J., Malik, HS., Matthews, KA., O'Connor-Giles, KM., Parks, AL., Perrimon, N., Port, F., Russell, S., Ueda, R., Wildonger, J. (2015). BIOSAFETY. Safeguarding gene drive experiments in the laboratory. Science. 349(6251):927-9 (abstract)
 
Alpert, AJ., Hudecz, O., Mechtler, K. (2015). Anion-exchange chromatography of phosphopeptides: weak anion exchange versus strong anion exchange and anion-exchange chromatography versus electrostatic repulsion-hydrophilic interaction chromatography. Anal Chem. 87(9):4704-11 (abstract)
 
Asaoka, T., Ikeda, F. (2015). New Insights into the Role of Ubiquitin Networks in the Regulation of Antiapoptosis Pathways. Int Rev Cell Mol Biol. 318:121-58 (abstract)
 
Ballard, MS., Zhu, A., Iwai, N., Stensrud, M., Mapps, A., Postiglione, MP., Knoblich, JA., Hinck, L. (2015). Mammary Stem Cell Self-Renewal Is Regulated by Slit2/Robo1 Signaling through SNAI1 and mINSC. Cell Rep. (abstract)
 
Bauer, M., Trupke, J., Ringrose, L. (2015). The quest for mammalian Polycomb response elements: are we there yet? Chromosoma. (abstract)
 
Bortolamiol-Becet, D., Hu, F., Jee, D., Wen, J., Okamura, K., Lin, CJ., Ameres, SL., Lai, EC. (2015). Selective Suppression of the Splicing-Mediated MicroRNA Pathway by the Terminal Uridyltransferase Tailor. Mol Cell. 59(2):217-28 (abstract)
 
Camp, JG., Badsha, F., Florio, M., Kanton, S., Gerber, T., Wilsch-Bräuninger, M., Lewitus, E., Sykes, A., Hevers, W., Lancaster, M., Knoblich, JA., Lachmann, R., Pääbo, S., Huttner, WB., Treutlein, B. (2015). Human cerebral organoids recapitulate gene expression programs of fetal neocortex development. Proc Natl Acad Sci U S A. 112(51):15672-7 (abstract)
 
Cheloufi, S., Elling, U., Hopfgartner, B., Jung, YL., Murn, J., Ninova, M., Hubmann, M., Badeaux, AI., Euong Ang, C., Tenen, D., Wesche, DJ., Abazova, N., Hogue, M., Tasdemir, N., Brumbaugh, J., Rathert, P., Jude, J., Ferrari, F., Blanco, A., Fellner, M., Wenzel, D., Zinner, M., Vidal, SE., Bell, O., Stadtfeld, M., Chang, HY., Almouzni, G., Lowe, SW., Rinn, J., Wernig, M., Aravin, A., Shi, Y., Park, PJ., Penninger, JM., Zuber, J., Hochedlinger, K. (2015). The histone chaperone CAF-1 safeguards somatic cell identity. Nature. 528(7581):218-24 (abstract)
 
Chen, Y., Di Grappa, MA., Molyneux, SD., McKee, TD., Waterhouse, P., Penninger, JM., Khokha, R. (2015). RANKL blockade prevents and treats aggressive osteosarcomas. Sci Transl Med. 7(317):317ra197 (abstract)
 
DiMaio, F., Song, Y., Li, X., Brunner, MJ., Xu, C., Conticello, V., Egelman, E., Marlovits, TC., Cheng, Y., Baker, D. (2015). Atomic-accuracy models from 4.5-Å cryo-electron microscopy data with density-guided iterative local refinement. Nat Methods. 12(4):361-5 (abstract)
 
Dufresne, SS., Dumont, NA., Bouchard, P., Lavergne, É., Penninger, JM., Frenette, J. (2015). Osteoprotegerin protects against muscular dystrophy. Am J Pathol. 185(4):920-6 (abstract)
 
Galluzzi, L., Bravo-San Pedro, JM., Vitale, I., Aaronson, SA., Abrams, JM., Adam, D., Alnemri, ES., Altucci, L., Andrews, D., Annicchiarico-Petruzzelli, M., Baehrecke, EH., Bazan, NG., Bertrand, MJ., Bianchi, K., Blagosklonny, MV., Blomgren, K., Borner, C., Bredesen, DE., Brenner, C., Campanella, M., Candi, E., Cecconi, F., Chan, FK., Chandel, NS., Cheng, EH., Chipuk, JE., Cidlowski, JA., Ciechanover, A., Dawson, TM., Dawson, VL., De Laurenzi, V., De Maria, R., Debatin, KM., Di Daniele, N., Dixit, VM., Dynlacht, BD., El-Deiry, WS., Fimia, GM., Flavell, RA., Fulda, S., Garrido, C., Gougeon, ML., Green, DR., Gronemeyer, H., Hajnoczky, G., Hardwick, JM., Hengartner, MO., Ichijo, H., Joseph, B., Jost, PJ., Kaufmann, T., Kepp, O., Klionsky, DJ., Knight, RA., Kumar, S., Lemasters, JJ., Levine, B., Linkermann, A., Lipton, SA., Lockshin, RA., López-Otín, C., Lugli, E., Madeo, F., Malorni, W., Marine, JC., Martin, SJ., Martinou, JC., Medema, JP., Meier, P., Melino, S., Mizushima, N., Moll, U., Muñoz-Pinedo, C., Nuñez, G., Oberst, A., Panaretakis, T., Penninger, JM., Peter, ME., Piacentini, M., Pinton, P., Prehn, JH., Puthalakath, H., Rabinovich, GA., Ravichandran, KS., Rizzuto, R., Rodrigues, CM., Rubinsztein, DC., Rudel, T., Shi, Y., Simon, HU., Stockwell, BR., Szabadkai, G., Tait, SW., Tang, HL., Tavernarakis, N., Tsujimoto, Y., Vanden Berghe, T., Vandenabeele, P., Villunger, A., Wagner, EF., Walczak, H., White, E., Wood, WG., Yuan, J., Zakeri, Z., Zhivotovsky, B., Melino, G., Kroemer, G. (2015). Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ. 22(1):58-73 (abstract)
 
Galluzzi, L., Pietrocola, F., Bravo-San Pedro, JM., Amaravadi, RK., Baehrecke, EH., Cecconi, F., Codogno, P., Debnath, J., Gewirtz, DA., Karantza, V., Kimmelman, A., Kumar, S., Levine, B., Maiuri, MC., Martin, SJ., Penninger, J., Piacentini, M., Rubinsztein, DC., Simon, HU., Simonsen, A., Thorburn, AM., Velasco, G., Ryan, KM., Kroemer, G. (2015). Autophagy in malignant transformation and cancer progression. EMBO J. 34(7):856-80 (abstract)
 
Gentili, C., Castor, D., Kaden, S., Lauterbach, D., Gysi, M., Steigemann, P., Gerlich, DW., Jiricny, J., Ferrari, S. (2015). Chromosome Missegregation Associated with RUVBL1 Deficiency. PLoS One. 10(7):e0133576 (abstract)
 
Grabner, B., Schramek, D., Mueller, KM., Moll, HP., Svinka, J., Hoffmann, T., Bauer, E., Blaas, L., Hruschka, N., Zboray, K., Stiedl, P., Nivarthi, H., Bogner, E., Gruber, W., Mohr, T., Zwick, RH., Kenner, L., Poli, V., Aberger, F., Stoiber, D., Egger, G., Esterbauer, H., Zuber, J., Moriggl, R., Eferl, R., Győrffy, B., Penninger, JM., Popper, H., Casanova, E. (2015). Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis. Nat Commun. 6:6285 (abstract)
 
Greenblatt, MB., Park, KH., Oh, H., Kim, JM., Shin, DY., Lee, JM., Lee, JW., Singh, A., Lee, KY., Hu, D., Xiao, C., Charles, JF., Penninger, JM., Lotinun, S., Baron, R., Ghosh, S., Shim, JH. (2015). CHMP5 controls bone turnover rates by dampening NF-κB activity in osteoclasts. J Exp Med. 212(8):1283-301 (abstract)
 
Guerrini, MM., Okamoto, K., Komatsu, N., Sawa, S., Danks, L., Penninger, JM., Nakashima, T., Takayanagi, H. (2015). Inhibition of the TNF Family Cytokine RANKL Prevents Autoimmune Inflammation in the Central Nervous System. Immunity. 43(6):1174-85 (abstract)
 
Hayashi, A., Mochizuki, K. (2015). Targeted Gene Disruption by Ectopic Induction of DNA Elimination in Tetrahymena. Genetics. 201(1):55-64 (abstract)
 
Heier, C., Radner, FP., Moustafa, T., Schreiber, R., Grond, S., Eichmann, TO., Schweiger, M., Schmidt, A., Cerk, IK., Oberer, M., Theussl, HC., Wojciechowski, J., Penninger, JM., Zimmermann, R., Zechner, R. (2015). G0/G1 Switch Gene 2 Regulates Cardiac Lipolysis. J Biol Chem. 290(43):26141-50 (abstract)
 
Herzog, VA., Ameres, SL. (2015). Approaching the Golden Fleece a Molecule at a Time: Biophysical Insights into Argonaute-Instructed Nucleic Acid Interactions. Mol Cell. 59(1):4-7 (abstract)
 
Homem, CC., Repic, M., Knoblich, JA. (2015). Proliferation control in neural stem and progenitor cells. Nat Rev Neurosci. 16(11):647-59 (abstract)
 
Iacovella, MG., Golfieri, C., Massari, LF., Busnelli, S., Pagliuca, C., Dal Maschio, M., Infantino, V., Visintin, R., Mechtler, K., Ferreira-Cerca, S., De Wulf, P. (2015). Rio1 promotes rDNA stability and downregulates RNA polymerase I to ensure rDNA segregation. Nat Commun. 6:6643 (abstract)
 
Ikeda, F. (2015). Linear ubiquitination signals in adaptive immune responses. Immunol Rev. 266(1):222-36 (abstract)
 
Joshi, PA., Waterhouse, PD., Kannan, N., Narala, S., Fang, H., Di Grappa, MA., Jackson, HW., Penninger, JM., Eaves, C., Khokha, R. (2015). RANK Signaling Amplifies WNT-Responsive Mammary Progenitors through R-SPONDIN1. Stem Cell Reports. 5(1):31-44 (abstract)
 
Kataoka, K., Mochizuki, K. (2015). Phosphorylation of an HP1-like Protein Regulates Heterochromatin Body Assembly for DNA Elimination. Dev Cell. 35(6):775-88 (abstract)
 
Kirli, K., Karaca, S., Dehne, HJ., Samwer, M., Pan, KT., Lenz, C., Urlaub, H., Görlich, D. (2015). A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. Elife. 4 (abstract)
 
Kondegowda, NG., Fenutria, R., Pollack, IR., Orthofer, M., Garcia-Ocaña, A., Penninger, JM., Vasavada, RC. (2015). Osteoprotegerin and Denosumab Stimulate Human Beta Cell Proliferation through Inhibition of the Receptor Activator of NF-κB Ligand Pathway. Cell Metab. 22(1):77-85 (abstract)
 
Krüttner, S., Traunmüller, L., Dag, U., Jandrasits, K., Stepien, B., Iyer, N., Fradkin, LG., Noordermeer, JN., Mensh, BD., Keleman, K. (2015). Synaptic Orb2A Bridges Memory Acquisition and Late Memory Consolidation in Drosophila. Cell Rep. 11(12):1953-65 (abstract)
 
Kulinski, TM., Casari, MR., Guenzl, PM., Wenzel, D., Andergassen, D., Hladik, A., Datlinger, P., Farlik, M., Theussl, HC., Penninger, JM., Knapp, S., Bock, C., Barlow, DP., Hudson, QJ. (2015). Imprinted expression in cystic embryoid bodies shows an embryonic and not an extra-embryonic pattern. Dev Biol. 402(2):291-305 (abstract)
 
Lambing, C., Osman, K., Nuntasoontorn, K., West, A., Higgins, JD., Copenhaver, GP., Yang, J., Armstrong, SJ., Mechtler, K., Roitinger, E., Franklin, FC. (2015). Arabidopsis PCH2 Mediates Meiotic Chromosome Remodeling and Maturation of Crossovers. PLoS Genet. 11(7):e1005372 (abstract)
 
Latremoliere, A., Latini, A., Andrews, N., Cronin, SJ., Fujita, M., Gorska, K., Hovius, R., Romero, C., Chuaiphichai, S., Painter, M., Miracca, G., Babaniyi, O., Remor, AP., Duong, K., Riva, P., Barrett, LB., Ferreirós, N., Naylor, A., Penninger, JM., Tegeder, I., Zhong, J., Blagg, J., Channon, KM., Johnsson, K., Costigan, M., Woolf, CJ. (2015). Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway. Neuron. 86(6):1393-406 (abstract)
 
Lempradl, A., Pospisilik, JA., Penninger, JM. (2015). Exploring the emerging complexity in transcriptional regulation of energy homeostasis. Nat Rev Genet. 16(11):665-81 (abstract)
 
Lukinavičius, G., Blaukopf, C., Pershagen, E., Schena, A., Reymond, L., Derivery, E., Gonzalez-Gaitan, M., D'Este, E., Hell, SW., Gerlich, DW., Johnsson, K. (2015). SiR-Hoechst is a far-red DNA stain for live-cell nanoscopy. Nat Commun. 6:8497 (abstract)
 
Marinov, GK., Wang, J., Handler, D., Wold, BJ., Weng, Z., Hannon, GJ., Aravin, AA., Zamore, PD., Brennecke, J., Toth, KF. (2015). Pitfalls of mapping high-throughput sequencing data to repetitive sequences: Piwi's genomic targets still not identified. Dev Cell. 32(6):765-71 (abstract)
 
Mieck, C., Molodtsov, MI., Drzewicka, K., van der Vaart, B., Litos, G., Schmauss, G., Vaziri, A., Westermann, S. (2015). Non-catalytic motor domains enable processive movement and functional diversification of the kinesin-14 Kar3. Elife. 4 (abstract)
 
Mohn, F., Handler, D., Brennecke, J. (2015). Noncoding RNA. piRNA-guided slicing specifies transcripts for Zucchini-dependent, phased piRNA biogenesis. Science. 348(6236):812-7 (abstract)
 
Nagy, V., Cole, T., Van Campenhout, C., Khoung, TM., Leung, C., Vermeiren, S., Novatchkova, M., Wenzel, D., Cikes, D., Polyansky, AA., Kozieradzki, I., Meixner, A., Bellefroid, EJ., Neely, GG., Penninger, JM. (2015). The evolutionarily conserved transcription factor PRDM12 controls sensory neuron development and pain perception. Cell Cycle. 14(12):1799-808 (abstract)
 
Nagy, V., Penninger, JM. (2015). The RANKL-RANK Story. Gerontology. 61(6):534-42 (abstract)
 
Nakajima, K., Zhu, K., Sun, YH., Hegyi, B., Zeng, Q., Murphy, CJ., Small, JV., Chen-Izu, Y., Izumiya, Y., Penninger, JM., Zhao, M. (2015). KCNJ15/Kir4.2 couples with polyamines to sense weak extracellular electric fields in galvanotaxis. Nat Commun. 6:8532 (abstract)
 
Nasso, S., Hartler, J., Trajanoski, Z., Di Camillo, B., Mechtler, K., Toffolo, GM. (2015). 3DSpectra: A 3-dimensional quantification algorithm for LC-MS labeled profile data. J Proteomics. 112:156-65 (abstract)
 
Noto, T., Kataoka, K., Suhren, JH., Hayashi, A., Woolcock, KJ., Gorovsky, MA., Mochizuki, K. (2015). Small-RNA-Mediated Genome-wide trans-Recognition Network in Tetrahymena DNA Elimination. Mol Cell. 59(2):229-42 (abstract)
 
Phadnis, N., Cipak, L., Polakova, S., Hyppa, RW., Cipakova, I., Anrather, D., Karvaiova, L., Mechtler, K., Smith, GR., Gregan, J. (2015). Casein Kinase 1 and Phosphorylation of Cohesin Subunit Rec11 (SA3) Promote Meiotic Recombination through Linear Element Formation. PLoS Genet. 11(5):e1005225 (abstract)
 
Polizzotti, BD., Ganapathy, B., Walsh, S., Choudhury, S., Ammanamanchi, N., Bennett, DG., dos Remedios, CG., Haubner, BJ., Penninger, JM., Kühn, B. (2015). Neuregulin stimulation of cardiomyocyte regeneration in mice and human myocardium reveals a therapeutic window. Sci Transl Med. 7(281):281ra45 (abstract)
 
Prakash, K., Fournier, D., Redl, S., Best, G., Borsos, M., Tiwari, VK., Tachibana-Konwalski, K., Ketting, RF., Parekh, SH., Cremer, C., Birk, UJ. (2015). Superresolution imaging reveals structurally distinct periodic patterns of chromatin along pachytene chromosomes. Proc Natl Acad Sci U S A. 112(47):14635-40 (abstract)
 
Rampler, E., Stranzl, T., Orban-Nemeth, Z., Hollenstein, DM., Hudecz, O., Schloegelhofer, P., Mechtler, K. (2015). Comprehensive Cross-Linking Mass Spectrometry Reveals Parallel Orientation and Flexible Conformations of Plant HOP2-MND1. J Proteome Res. 14(12):5048-62 (abstract)
 
Reimão-Pinto, MM., Ignatova, V., Burkard, TR., Hung, JH., Manzenreither, RA., Sowemimo, I., Herzog, VA., Reichholf, B., Fariña-Lopez, S., Ameres, SL. (2015). Uridylation of RNA Hairpins by Tailor Confines the Emergence of MicroRNAs in Drosophila. Mol Cell. 59(2):203-16 (abstract)
 
Roitinger, E., Hofer, M., Köcher, T., Pichler, P., Novatchkova, M., Yang, J., Schlögelhofer, P., Mechtler, K. (2015). Quantitative phosphoproteomics of the ataxia telangiectasia-mutated (ATM) and ataxia telangiectasia-mutated and rad3-related (ATR) dependent DNA damage response in Arabidopsis thaliana. Mol Cell Proteomics. 14(3):556-71 (abstract)
 
Rudolph, D., Impagnatiello, MA., Blaukopf, C., Sommer, C., Gerlich, DW., Roth, M., Tontsch-Grunt, U., Wernitznig, A., Savarese, F., Hofmann, MH., Albrecht, C., Geiselmann, L., Reschke, M., Garin-Chesa, P., Zuber, J., Moll, J., Adolf, GR., Kraut, N. (2015). Efficacy and mechanism of action of volasertib, a potent and selective inhibitor of Polo-like kinases, in preclinical models of acute myeloid leukemia. J Pharmacol Exp Ther. 352(3):579-89 (abstract)
 
Schuetz T, Kuehn B, Penninger JM, Haubner BJ (2015). Direct comparison of ischemic- vs. cryoinjury in the neonatal mouse heart. Wiener Klinische Wochenschrift. (127):9-10
 
Senti, KA., Jurczak, D., Sachidanandam, R., Brennecke, J. (2015). piRNA-guided slicing of transposon transcripts enforces their transcriptional silencing via specifying the nuclear piRNA repertoire. Genes Dev. 29(16):1747-62 (abstract)
 
Sienski, G., Batki, J., Senti, KA., Dönertas, D., Tirian, L., Meixner, K., Brennecke, J. (2015). Silencio/CG9754 connects the Piwi-piRNA complex to the cellular heterochromatin machinery. Genes Dev. 29(21):2258-71 (abstract)
 
Small, JV. (2015). Pushing with actin: from cells to pathogens. Biochem Soc Trans. 43(1):84-91 (abstract)
 
Sun, Y., Guo, F., Zou, Z., Li, C., Hong, X., Zhao, Y., Wang, C., Wang, H., Liu, H., Yang, P., Han, Z., Liu, K., Kuba, K., Song, B., Gao, J., Mo, Z., Li, D., Li, B., Li, Q., Zhong, N., Wang, C., Penninger, JM., Jiang, C. (2015). Cationic nanoparticles directly bind angiotensin-converting enzyme 2 and induce acute lung injury in mice. Part Fibre Toxicol. 12:4 (abstract)
 
Tachibana-Konwalski, K. (2015). Cell division: Hold on and let go. Nature. 517(7535):441-2 (abstract)
 
Talbot, S., Abdulnour, RE., Burkett, PR., Lee, S., Cronin, SJ., Pascal, MA., Laedermann, C., Foster, SL., Tran, JV., Lai, N., Chiu, IM., Ghasemlou, N., DiBiase, M., Roberson, D., Von Hehn, C., Agac, B., Haworth, O., Seki, H., Penninger, JM., Kuchroo, VK., Bean, BP., Levy, BD., Woolf, CJ. (2015). Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation. Neuron. 87(2):341-54 (abstract)
 
Tsvetkov, P., Mendillo, ML., Zhao, J., Carette, JE., Merrill, PH., Cikes, D., Varadarajan, M., van Diemen, FR., Penninger, JM., Goldberg, AL., Brummelkamp, TR., Santagata, S., Lindquist, S. (2015). Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome. Elife. 4 (abstract)
 
Weitzer, S., Hanada, T., Penninger, JM., Martinez, J. (2015). CLP1 as a novel player in linking tRNA splicing to neurodegenerative disorders. Wiley Interdiscip Rev RNA. 6(1):47-63 (abstract)
 
Woehrer, SL., Aronica, L., Suhren, JH., Busch, CJ., Noto, T., Mochizuki, K. (2015). A Tetrahymena Hsp90 co-chaperone promotes siRNA loading by ATP-dependent and ATP-independent mechanisms. EMBO J. 34(4):559-77 (abstract)
 

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