2014

Ayukawa, T., Akiyama, M., Mummery-Widmer, JL., Stoeger, T., Sasaki, J., Knoblich, JA., Senoo, H., Sasaki, T., Yamazaki, M. (2014). Dachsous-dependent asymmetric localization of spiny-legs determines planar cell polarity orientation in Drosophila. Cell Rep. 8(2):610-21 (abstract)
 
Boztug, K., Järvinen, PM., Salzer, E., Racek, T., Mönch, S., Garncarz, W., Gertz, EM., Schäffer, AA., Antonopoulos, A., Haslam, SM., Schieck, L., Puchałka, J., Diestelhorst, J., Appaswamy, G., Lescoeur, B., Giambruno, R., Bigenzahn, JW., Elling, U., Pfeifer, D., Conde, CD., Albert, MH., Welte, K., Brandes, G., Sherkat, R., van der Werff Ten Bosch, J., Rezaei, N., Etzioni, A., Bellanné-Chantelot, C., Superti-Furga, G., Penninger, JM., Bennett, KL., von Blume, J., Dell, A., Donadieu, J., Klein, C. (2014). JAGN1 deficiency causes aberrant myeloid cell homeostasis and congenital neutropenia. Nat Genet. 46(9):1021-7 (abstract)
 
Dorfer, V., Pichler, P., Stranzl, T., Stadlmann, J., Taus, T., Winkler, S., Mechtler, K. (2014). MS Amanda, a universal identification algorithm optimized for high accuracy tandem mass spectra. J Proteome Res. 13(8):3679-84 (abstract)
 
Dürnberger, G., Camurdanoglu, BZ., Tomschik, M., Schutzbier, M., Roitinger, E., Hudecz, O., Mechtler, K., Herbst, R. (2014). Global analysis of muscle-specific kinase signaling by quantitative phosphoproteomics. Mol Cell Proteomics. 13(8):1993-2003 (abstract)
 
Elling, U., Penninger, JM. (2014). Genome wide functional genetics in haploid cells. FEBS Lett. 588(15):2415-21 (abstract)
 
Eroglu, E., Burkard, TR., Jiang, Y., Saini, N., Homem, CC., Reichert, H., Knoblich, JA. (2014). SWI/SNF complex prevents lineage reversion and induces temporal patterning in neural stem cells. Cell. 156(6):1259-73 (abstract)
 
Galán, JE., Lara-Tejero, M., Marlovits, TC., Wagner, S. (2014). Bacterial type III secretion systems: specialized nanomachines for protein delivery into target cells. Annu Rev Microbiol. 68:415-38 (abstract)
 
Gokcezade, J., Sienski, G., Duchek, P. (2014). Efficient CRISPR/Cas9 plasmids for rapid and versatile genome editing in Drosophila. G3 (Bethesda). 4(11):2279-82 (abstract)
 
Hagelkruys, A., Lagger, S., Krahmer, J., Leopoldi, A., Artaker, M., Pusch, O., Zezula, J., Weissmann, S., Xie, Y., Schöfer, C., Schlederer, M., Brosch, G., Matthias, P., Selfridge, J., Lassmann, H., Knoblich, JA., Seiser, C. (2014). A single allele of Hdac2 but not Hdac1 is sufficient for normal mouse brain development in the absence of its paralog. Development. 141(3):604-16 (abstract)
 
Hayashi, R., Handler, D., Ish-Horowicz, D., Brennecke, J. (2014). The exon junction complex is required for definition and excision of neighboring introns in Drosophila. Genes Dev. 28(16):1772-85 (abstract)
 
Herzog, VA., Lempradl, A., Trupke, J., Okulski, H., Altmutter, C., Ruge, F., Boidol, B., Kubicek, S., Schmauss, G., Aumayr, K., Ruf, M., Pospisilik, A., Dimond, A., Senergin, HB., Vargas, ML., Simon, JA., Ringrose, L. (2014). A strand-specific switch in noncoding transcription switches the function of a Polycomb/Trithorax response element. Nat Genet. 46(9):973-81 (abstract)
 
Hofbauer, HF., Schopf, FH., Schleifer, H., Knittelfelder, OL., Pieber, B., Rechberger, GN., Wolinski, H., Gaspar, ML., Kappe, CO., Stadlmann, J., Mechtler, K., Zenz, A., Lohner, K., Tehlivets, O., Henry, SA., Kohlwein, SD. (2014). Regulation of gene expression through a transcriptional repressor that senses acyl-chain length in membrane phospholipids. Dev Cell. 29(6):729-39 (abstract)
 
Homem, CC., Steinmann, V., Burkard, TR., Jais, A., Esterbauer, H., Knoblich, JA. (2014). Ecdysone and mediator change energy metabolism to terminate proliferation in Drosophila neural stem cells. Cell. 158(4):874-88 (abstract)
 
Hornung, P., Troc, P., Malvezzi, F., Maier, M., Demianova, Z., Zimniak, T., Litos, G., Lampert, F., Schleiffer, A., Brunner, M., Mechtler, K., Herzog, F., Marlovits, TC., Westermann, S. (2014). A cooperative mechanism drives budding yeast kinetochore assembly downstream of CENP-A. J Cell Biol. 206(4):509-24 (abstract)
 
Huang, F., Guo, J., Zou, Z., Liu, J., Cao, B., Zhang, S., Li, H., Wang, W., Sheng, M., Liu, S., Pan, J., Bao, C., Zeng, M., Xiao, H., Qian, G., Hu, X., Chen, Y., Chen, Y., Zhao, Y., Liu, Q., Zhou, H., Zhu, J., Gao, H., Yang, S., Liu, X., Zheng, S., Yang, J., Diao, H., Cao, H., Wu, Y., Zhao, M., Tan, S., Guo, D., Zhao, X., Ye, Y., Wu, W., Xu, Y., Penninger, JM., Li, D., Gao, GF., Jiang, C., Li, L. (2014). Angiotensin II plasma levels are linked to disease severity and predict fatal outcomes in H7N9-infected patients. Nat Commun. 5:3595 (abstract)
 
Itoh, T., Horiuchi, M., Ikeda, RH., Xu, J., Bannerman, P., Pleasure, D., Penninger, JM., Tournier, C., Itoh, A. (2014). ZPK/DLK and MKK4 form the critical gateway to axotomy-induced motoneuron death in neonates. J Neurosci. 34(32):10729-42 (abstract)
 
Jurkin, J., Henkel, T., Nielsen, AF., Minnich, M., Popow, J., Kaufmann, T., Heindl, K., Hoffmann, T., Busslinger, M., Martinez, J. (2014). The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells. EMBO J. 33(24):2922-36 (abstract)
 
Jüschke, C., Xie, Y., Postiglione, MP., Knoblich, JA. (2014). Analysis and modeling of mitotic spindle orientations in three dimensions. Proc Natl Acad Sci U S A. 111(3):1014-9 (abstract)
 
Karaca, E., Weitzer, S., Pehlivan, D., Shiraishi, H., Gogakos, T., Hanada, T., Jhangiani, SN., Wiszniewski, W., Withers, M., Campbell, IM., Erdin, S., Isikay, S., Franco, LM., Gonzaga-Jauregui, C., Gambin, T., Gelowani, V., Hunter, JV., Yesil, G., Koparir, E., Yilmaz, S., Brown, M., Briskin, D., Hafner, M., Morozov, P., Farazi, TA., Bernreuther, C., Glatzel, M., Trattnig, S., Friske, J., Kronnerwetter, C., Bainbridge, MN., Gezdirici, A., Seven, M., Muzny, DM., Boerwinkle, E., Ozen, M., Clausen, T., Tuschl, T., Yuksel, A., Hess, A., Gibbs, RA., Martinez, J., Penninger, JM., Lupski, JR. (2014). Human CLP1 mutations alter tRNA biogenesis, affecting both peripheral and central nervous system function. Cell. 157(3):636-50 (abstract)
 
Köcher, T., Pichler, P., De Pra, M., Rieux, L., Swart, R., Mechtler, K. (2014). Development and performance evaluation of an ultralow flow nanoliquid chromatography-tandem mass spectrometry set-up. Proteomics. 14(17-18):1999-2007 (abstract)
 
Kotsinas, A., Papanagnou, P., Galanos, P., Schramek, D., Townsend, P., Penninger, JM., Bartek, J., Gorgoulis, VG. (2014). MKK7 and ARF: new players in the DNA damage response scenery. Cell Cycle. 13(8):1227-36 (abstract)
 
Kumari, S., Redouane, Y., Lopez-Mosqueda, J., Shiraishi, R., Romanowska, M., Lutzmayer, S., Kuiper, J., Martinez, C., Dikic, I., Pasparakis, M., Ikeda, F. (2014). Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis. Elife. 3 (abstract)
 
Lancaster, MA., Knoblich, JA. (2014). Generation of cerebral organoids from human pluripotent stem cells. Nat Protoc. 9(10):2329-40 (abstract)
 
Lancaster, MA., Knoblich, JA. (2014). Organogenesis in a dish: modeling development and disease using organoid technologies. Science. 345(6194):1247125 (abstract)
 
Lukinavičius, G., Reymond, L., D'Este, E., Masharina, A., Göttfert, F., Ta, H., Güther, A., Fournier, M., Rizzo, S., Waldmann, H., Blaukopf, C., Sommer, C., Gerlich, DW., Arndt, HD., Hell, SW., Johnsson, K. (2014). Fluorogenic probes for live-cell imaging of the cytoskeleton. Nat Methods. 11(7):731-3 (abstract)
 
Marchetti, G., Reichardt, I., Knoblich, JA., Besse, F. (2014). The TRIM-NHL protein Brat promotes axon maintenance by repressing src64B expression. J Neurosci. 34(41):13855-64 (abstract)
 
Mauri, F., Reichardt, I., Mummery-Widmer, JL., Yamazaki, M., Knoblich, JA. (2014). The conserved discs-large binding partner Banderuola regulates asymmetric cell division in Drosophila. Curr Biol. 24(16):1811-25 (abstract)
 
Mérai, Z., Chumak, N., García-Aguilar, M., Hsieh, TF., Nishimura, T., Schoft, VK., Bindics, J., Slusarz, L., Arnoux, S., Opravil, S., Mechtler, K., Zilberman, D., Fischer, RL., Tamaru, H. (2014). The AAA-ATPase molecular chaperone Cdc48/p97 disassembles sumoylated centromeres, decondenses heterochromatin, and activates ribosomal RNA genes. Proc Natl Acad Sci U S A. 111(45):16166-71 (abstract)
 
Mertz, KD., Pathria, G., Wagner, C., Saarikangas, J., Sboner, A., Romanov, J., Gschaider, M., Lenz, F., Neumann, F., Schreiner, W., Nemethova, M., Glassmann, A., Lappalainen, P., Stingl, G., Small, JV., Fink, D., Chin, L., Wagner, SN. (2014). MTSS1 is a metastasis driver in a subset of human melanomas. Nat Commun. 5:3465 (abstract)
 
Mierzwa, B., Gerlich, DW. (2014). Cytokinetic abscission: molecular mechanisms and temporal control. Dev Cell. 31(5):525-38 (abstract)
 
Moczulska, KE., Pichler, P., Schutzbier, M., Schleiffer, A., Rumpel, S., Mechtler, K. (2014). Deep and precise quantification of the mouse synaptosomal proteome reveals substantial remodeling during postnatal maturation. J Proteome Res. 13(10):4310-24 (abstract)
 
Mohn, F., Sienski, G., Handler, D., Brennecke, J. (2014). The rhino-deadlock-cutoff complex licenses noncanonical transcription of dual-strand piRNA clusters in Drosophila. Cell. 157(6):1364-79 (abstract)
 
Mueller, J., Pfanzelter, J., Winkler, C., Narita, A., Le Clainche, C., Nemethova, M., Carlier, MF., Maeda, Y., Welch, MD., Ohkawa, T., Schmeiser, C., Resch, GP., Small, JV. (2014). Electron tomography and simulation of baculovirus actin comet tails support a tethered filament model of pathogen propulsion. PLoS Biol. 12(1):e1001765 (abstract)
 
Noto, T., Kurth, HM., Mochizuki, K. (2014). Analysis of Piwi-loaded small RNAs in Tetrahymena. Methods Mol Biol. 1093:209-24 (abstract)
 
Paolino, M., Choidas, A., Wallner, S., Pranjic, B., Uribesalgo, I., Loeser, S., Jamieson, AM., Langdon, WY., Ikeda, F., Fededa, JP., Cronin, SJ., Nitsch, R., Schultz-Fademrecht, C., Eickhoff, J., Menninger, S., Unger, A., Torka, R., Gruber, T., Hinterleitner, R., Baier, G., Wolf, D., Ullrich, A., Klebl, BM., Penninger, JM. (2014). The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells. Nature. 507(7493):508-12 (abstract)
 
Popow, J., Jurkin, J., Schleiffer, A., Martinez, J. (2014). Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors. Nature. 511(7507):104-7 (abstract)
 
Qiao, G., Ying, H., Zhao, Y., Liang, Y., Guo, H., Shen, H., Li, Z., Solway, J., Tao, E., Chiang, YJ., Lipkowitz, S., Penninger, JM., Langdon, WY., Zhang, J. (2014). E3 ubiquitin ligase Cbl-b suppresses proallergic T cell development and allergic airway inflammation. Cell Rep. 6(4):709-23 (abstract)
 
Rack, JG., Lutter, T., Kjæreng Bjerga, GE., Guder, C., Ehrhardt, C., Värv, S., Ziegler, M., Aasland, R. (2014). The PHD finger of p300 influences its ability to acetylate histone and non-histone targets. J Mol Biol. 426(24):3960-72 (abstract)
 
Radics, J., Königsmaier, L., Marlovits, TC. (2014). Structure of a pathogenic type 3 secretion system in action. Nat Struct Mol Biol. 21(1):82-7 (abstract)
 
Rao, S., Tortola, L., Perlot, T., Wirnsberger, G., Novatchkova, M., Nitsch, R., Sykacek, P., Frank, L., Schramek, D., Komnenovic, V., Sigl, V., Aumayr, K., Schmauss, G., Fellner, N., Handschuh, S., Glösmann, M., Pasierbek, P., Schlederer, M., Resch, GP., Ma, Y., Yang, H., Popper, H., Kenner, L., Kroemer, G., Penninger, JM. (2014). A dual role for autophagy in a murine model of lung cancer. Nat Commun. 5:3056 (abstract)
 
Rao, S., Yang, H., Penninger, JM., Kroemer, G. (2014). Autophagy in non-small cell lung carcinogenesis: A positive regulator of antitumor immunosurveillance. Autophagy. 10(3):529-31 (abstract)
 
Rattani, A., Vinod, PK., Godwin, J., Tachibana-Konwalski, K., Wolna, M., Malumbres, M., Novák, B., Nasmyth, K. (2014). Dependency of the spindle assembly checkpoint on Cdk1 renders the anaphase transition irreversible. Curr Biol. 24(6):630-7 (abstract)
 
Róna, G., Borsos, M., Ellis, JJ., Mehdi, AM., Christie, M., Környei, Z., Neubrandt, M., Tóth, J., Bozóky, Z., Buday, L., Madarász, E., Bodén, M., Kobe, B., Vértessy, BG. (2014). Dynamics of re-constitution of the human nuclear proteome after cell division is regulated by NLS-adjacent phosphorylation. Cell Cycle. 13(22):3551-64 (abstract)
 
Rotblat, B., Southwell, AL., Ehrnhoefer, DE., Skotte, NH., Metzler, M., Franciosi, S., Leprivier, G., Somasekharan, SP., Barokas, A., Deng, Y., Tang, T., Mathers, J., Cetinbas, N., Daugaard, M., Kwok, B., Li, L., Carnie, CJ., Fink, D., Nitsch, R., Galpin, JD., Ahern, CA., Melino, G., Penninger, JM., Hayden, MR., Sorensen, PH. (2014). HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response. Proc Natl Acad Sci U S A. 111(8):3032-7 (abstract)
 
Sawicka, A., Hartl, D., Goiser, M., Pusch, O., Stocsits, RR., Tamir, IM., Mechtler, K., Seiser, C. (2014). H3S28 phosphorylation is a hallmark of the transcriptional response to cellular stress. Genome Res. 24(11):1808-20 (abstract)
 
Schmidt, A., Trentini, DB., Spiess, S., Fuhrmann, J., Ammerer, G., Mechtler, K., Clausen, T. (2014). Quantitative phosphoproteomics reveals the role of protein arginine phosphorylation in the bacterial stress response. Mol Cell Proteomics. 13(2):537-50 (abstract)
 
Shodhan, A., Lukaszewicz, A., Novatchkova, M., Loidl, J. (2014). Msh4 and Msh5 function in SC-independent chiasma formation during the streamlined meiosis of Tetrahymena. Genetics. 198(3):983-93 (abstract)
 
Sigl, V., Penninger, JM. (2014). RANKL/RANK - from bone physiology to breast cancer. Cytokine Growth Factor Rev. 25(2):205-14 (abstract)
 
Steffen, PA., Ringrose, L. (2014). What are memories made of? How Polycomb and Trithorax proteins mediate epigenetic memory. Nat Rev Mol Cell Biol. 15(5):340-56 (abstract)
 
Tomanov, K., Zeschmann, A., Hermkes, R., Eifler, K., Ziba, I., Grieco, M., Novatchkova, M., Hofmann, K., Hesse, H., Bachmair, A. (2014). Arabidopsis PIAL1 and 2 promote SUMO chain formation as E4-type SUMO ligases and are involved in stress responses and sulfur metabolism. Plant Cell. 26(11):4547-60 (abstract)
 
Trentini, DB., Fuhrmann, J., Mechtler, K., Clausen, T. (2014). Chasing phosphoarginine proteins: development of a selective enrichment method using a phosphatase trap. Mol Cell Proteomics. (abstract)
 
Vázquez-Novelle, MD., Sansregret, L., Dick, AE., Smith, CA., McAinsh, AD., Gerlich, DW., Petronczki, M. (2014). Cdk1 inactivation terminates mitotic checkpoint surveillance and stabilizes kinetochore attachments in anaphase. Curr Biol. 24(6):638-45 (abstract)
 
Vogt, A., Mochizuki, K. (2014). The taming of the shrew: Regulation of a catalytically active domesticated transposase. Mob Genet Elements. 4:e29383 (abstract)
 
Waidmann, S., Kusenda, B., Mayerhofer, J., Mechtler, K., Jonak, C. (2014). A DEK domain-containing protein modulates chromatin structure and function in Arabidopsis. Plant Cell. 26(11):4328-44 (abstract)
 
Walzer, M., Pernas, LE., Nasso, S., Bittremieux, W., Nahnsen, S., Kelchtermans, P., Pichler, P., van den Toorn, HW., Staes, A., Vandenbussche, J., Mazanek, M., Taus, T., Scheltema, RA., Kelstrup, CD., Gatto, L., van Breukelen, B., Aiche, S., Valkenborg, D., Laukens, K., Lilley, KS., Olsen, JV., Heck, AJ., Mechtler, K., Aebersold, R., Gevaert, K., Vizcaíno, JA., Hermjakob, H., Kohlbacher, O., Martens, L. (2014). qcML: an exchange format for quality control metrics from mass spectrometry experiments. Mol Cell Proteomics. 13(8):1905-13 (abstract)
 
Wang, W., Patel, VB., Parajuli, N., Fan, D., Basu, R., Wang, Z., Ramprasath, T., Kassiri, Z., Penninger, JM., Oudit, GY. (2014). Heterozygote loss of ACE2 is sufficient to increase the susceptibility to heart disease. J Mol Med (Berl). 92(8):847-58 (abstract)
 
Wenzel, D., Bayerl, J., Nyström, A., Bruckner-Tuderman, L., Meixner, A., Penninger, JM. (2014). Genetically corrected iPSCs as cell therapy for recessive dystrophic epidermolysis bullosa. Sci Transl Med. 6(264):264ra165 (abstract)
 
Williams, SE., Ratliff, LA., Postiglione, MP., Knoblich, JA., Fuchs, E. (2014). Par3-mInsc and Gαi3 cooperate to promote oriented epidermal cell divisions through LGN. Nat Cell Biol. 16(8):758-69 (abstract)
 
Wirnsberger, G., Zwolanek, F., Stadlmann, J., Tortola, L., Liu, SW., Perlot, T., Järvinen, P., Dürnberger, G., Kozieradzki, I., Sarao, R., De Martino, A., Boztug, K., Mechtler, K., Kuchler, K., Klein, C., Elling, U., Penninger, JM. (2014). Jagunal homolog 1 is a critical regulator of neutrophil function in fungal host defense. Nat Genet. 46(9):1028-33 (abstract)
 
Yang, P., Gu, H., Zhao, Z., Wang, W., Cao, B., Lai, C., Yang, X., Zhang, L., Duan, Y., Zhang, S., Chen, W., Zhen, W., Cai, M., Penninger, JM., Jiang, C., Wang, X. (2014). Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury. Sci Rep. 4:7027 (abstract)
 
Yasugi, T., Fischer, A., Jiang, Y., Reichert, H., Knoblich, JA. (2014). A regulatory transcriptional loop controls proliferation and differentiation in Drosophila neural stem cells. PLoS One. 9(5):e97034 (abstract)
 
Zhang, L., Chen, X., Sharma, P., Moon, M., Sheftel, AD., Dawood, F., Nghiem, MP., Wu, J., Li, RK., Gramolini, AO., Sorensen, PH., Penninger, JM., Brumell, JH., Liu, PP. (2014). HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress. Nat Commun. 5:3430 (abstract)
 
Zou, Z., Yan, Y., Shu, Y., Gao, R., Sun, Y., Li, X., Ju, X., Liang, Z., Liu, Q., Zhao, Y., Guo, F., Bai, T., Han, Z., Zhu, J., Zhou, H., Huang, F., Li, C., Lu, H., Li, N., Li, D., Jin, N., Penninger, JM., Jiang, C. (2014). Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections. Nat Commun. 5:3594 (abstract)
 

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