Fumiyo Ikeda

Inflammatory regulation by ubiquitin networks

  • Ubiquitin is one of the most sophisticated and versatile post-translational modifications that regulate numerous biological functions, including inflammation, apoptosis, cancer, cell cycle, DNA repair, Parkinson’s disease and endocytosis. Depending on how Ubiquitin molecules are linked by enzymatic actions, they can form different topological chains on target proteins. These ubiquitin chains with different “appearances” recruit distinct protein networks that function to specifically regulate various aspects of physiology. 
    By using various approaches from biochemistry techniques to genetically modified animal models, we aim to dissect how ubiquitin networks control inflammatory responses.

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    Fumiyo Ikeda
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Selected Publications

(2011)
 
Ikeda, F., Deribe, YL., Skånland, SS., Stieglitz, B., Grabbe, C., Franz-Wachtel, M., van Wijk, SJ., Goswami, P., Nagy, V., Terzic, J., Tokunaga, F., Androulidaki, A., Nakagawa, T., Pasparakis, M., Iwai, K., Sundberg, JP., Schaefer, L., Rittinger, K., Macek, B., Dikic, I. (2011). SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis. Nature. 471(7340):637-41 (abstract)
 
(2010)
 
Ikeda, F., Crosetto, N., Dikic, I. (2010). What determines the specificity and outcomes of ubiquitin signaling? Cell. 143(5):677-81 (abstract)
 
(2009)
 
Rahighi, S., Ikeda, F., Kawasaki, M., Akutsu, M., Suzuki, N., Kato, R., Kensche, T., Uejima, T., Bloor, S., Komander, D., Randow, F., Wakatsuki, S., Dikic, I. (2009). Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation. Cell. 136(6):1098-109 (abstract)
 
(2008)
 
Ikeda, F., Dikic, I. (2008). Atypical ubiquitin chains: new molecular signals. 'Protein Modifications: Beyond the Usual Suspects' review series. EMBO Rep. 9(6):536-42 (abstract)
 
(2007)
 
Ikeda, F., Hecker, CM., Rozenknop, A., Nordmeier, RD., Rogov, V., Hofmann, K., Akira, S., Dötsch, V., Dikic, I. (2007). Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes. EMBO J. 26(14):3451-62 (abstract)