Daniel Gerlich

Assembly and function of the cell division machinery

  • Dividing cells extensively reorganize their internal organelles to build a machinery for chromosome segregation and cytokinesis. Understanding how large numbers of molecular components self-organize to form higher-order structures like mitotic chromosomes, the mitotic spindle, and the actomyosin ring remains a major challenge. We use high-content screening, biophysical manipulations, and biochemical reconstitution to gain insights into the molecular mechanisms underlying morphogenesis and biomechanics of dividing cells.

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    Daniel Gerlich
    Senior Scientist
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Selected Publications

Cuylen, S., Blaukopf, C., Politi, AZ., Müller-Reichert, T., Neumann, B., Poser, I., Ellenberg, J., Hyman, AA., Gerlich, DW. (2016). Ki-67 acts as a biological surfactant to disperse mitotic chromosomes. Nature. 535(7611):308-12 (abstract)
Dick, AE., Gerlich, DW. (2013). Kinetic framework of spindle assembly checkpoint signalling. Nat Cell Biol. 15(11):1370-7 (abstract)
Guizetti, J., Schermelleh, L., Mäntler, J., Maar, S., Poser, I., Leonhardt, H., Müller-Reichert, T., Gerlich, DW. (2011). Cortical constriction during abscission involves helices of ESCRT-III-dependent filaments. Science. 331(6024):1616-20 (abstract)
Steigemann, P., Wurzenberger, C., Schmitz, MH., Held, M., Guizetti, J., Maar, S., Gerlich, DW. (2009). Aurora B-mediated abscission checkpoint protects against tetraploidization. Cell. 136(3):473-84 (abstract)

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