Daniel Gerlich

Assembly and function of the cell division machinery

  • The Gerlich laboratory studies how cells reorganize their internal components during the cell cycle. We are particularly interested in the compartmentalization of the mitotic cytoplasm, the structure and biophysical properties of human chromosomes, and chromosome interactions with cytoskeleton and membranes.

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    Daniel Gerlich
    Senior Scientist
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Selected Publications

Mierzwa, BE., Chiaruttini, N., Redondo-Morata, L., Moser von Filseck, J., König, J., Larios, J., Poser, I., Müller-Reichert, T., Scheuring, S., Roux, A., Gerlich, DW. (2017). Dynamic subunit turnover in ESCRT-III assemblies is regulated by Vps4 to mediate membrane remodelling during cytokinesis. Nat Cell Biol. (abstract)
Cuylen, S., Blaukopf, C., Politi, AZ., Müller-Reichert, T., Neumann, B., Poser, I., Ellenberg, J., Hyman, AA., Gerlich, DW. (2016). Ki-67 acts as a biological surfactant to disperse mitotic chromosomes. Nature. 535(7611):308-12 (abstract)
Dick, AE., Gerlich, DW. (2013). Kinetic framework of spindle assembly checkpoint signalling. Nat Cell Biol. 15(11):1370-7 (abstract)
Guizetti, J., Schermelleh, L., Mäntler, J., Maar, S., Poser, I., Leonhardt, H., Müller-Reichert, T., Gerlich, DW. (2011). Cortical constriction during abscission involves helices of ESCRT-III-dependent filaments. Science. 331(6024):1616-20 (abstract)

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