Daniel Gerlich

Assembly and function of the cell division machinery

  • Our laboratory is interested in understanding the molecular mechanisms underlying the morphogenesis and function of the cell division machinery. How does a shift in kinase and phosphatase activities promote the assembly and disassembly of mitotic structures? How are mitotic chromosomes shaped and what defines their biophysical properties? Why do cytokinetic cleavage furrow ingression and abscission involve distinct filament systems and how do these filaments generate contractile force? To address these questions, our interdisciplinary team of biologists and computer scientists uses state-of-the-art microscopy and computer vision methods, combined with genetic, chemical, and biophysical perturbations.

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    Daniel Gerlich
    Senior Scientist
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Selected Publications

Dick, AE., Gerlich, DW. (2013). Kinetic framework of spindle assembly checkpoint signalling. Nat Cell Biol. (abstract)
Zhong, Q., Busetto, AG., Fededa, JP., Buhmann, JM., Gerlich, DW. (2012). Unsupervised modeling of cell morphology dynamics for time-lapse microscopy. Nat Methods. 9(7):711-3 (abstract)
Guizetti, J., Schermelleh, L., Mäntler, J., Maar, S., Poser, I., Leonhardt, H., Müller-Reichert, T., Gerlich, DW. (2011). Cortical constriction during abscission involves helices of ESCRT-III-dependent filaments. Science. 331(6024):1616-20 (abstract)
Schmitz, MH., Held, M., Janssens, V., Hutchins, JR., Hudecz, O., Ivanova, E., Goris, J., Trinkle-Mulcahy, L., Lamond, AI., Poser, I., Hyman, AA., Mechtler, K., Peters, JM., Gerlich, DW. (2010). Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells. Nat Cell Biol. 12(9):886-93 (abstract)
Steigemann, P., Wurzenberger, C., Schmitz, MH., Held, M., Guizetti, J., Maar, S., Gerlich, DW. (2009). Aurora B-mediated abscission checkpoint protects against tetraploidization. Cell. 136(3):473-84 (abstract)